Results 41 to 50 of about 86,211 (210)

Intrinsic Photoactive Star ZnPc–Poly(glutamate) Nanoplatforms for Multimodal Glioblastoma Therapy and Brain‐Targeted Delivery

Advanced Functional Materials, EarlyView.
An intrinsic photoactive star‐shaped zinc phtalocyanine‐poly(L‐glutamic acid) (ZnPc‐PGA) nanoplatform for multimodal glioblastoma (GBM) therapy and brain‐targeted elivery. A ZnPc‐PGA‐based multifunctional theranostic nanocarrier platform enables image‐guided, multimodal GBM therapy. ZnPc‐PGA nanocarriers support the integration of fluorescence imaging,
Amina Benaicha‐Fernández, Teodora Ranđelović, Ana Armiñán, Víctor Sebastián, Manuel Fuentes, Cristián Huck‐Iriart, Esther Masiá, Paula Carrascosa‐Marco, Pablo Juanes‐Velasco, Snežana Đorđević, Clara Bayona, Ignacio Ochoa, Maria Medel, Inmaculada Conejos‐Sánchez, María J. Vicent   +14 more
wiley   +1 more source

Mechanisms of action and applications of Polygonatum sibiricum polysaccharide at the intestinal mucosa barrier: a review

Frontiers in Pharmacology
As a medicinal and edible homologous Chinese herb, Polygonatum sibiricum has been used as a primary ingredient in various functional and medicinal products. Damage to the intestinal mucosal barrier can lead to or worsen conditions such as type 2 diabetes
Yu Ren, Yu Ren, Yi Sun, Yu-Ying Liao, Si Wang, Si Wang, Qian Liu, Chun-Yan Duan, Lan Sun, Xiao-Ya Li, Jia-Li Yuan   +10 more
doaj   +1 more source

Research progress on intestinal mucosal barrier function， injury mechanism and nutritional regulation of fish

Siliao yanjiu, 2023
The intestine is an important organ for nutrient absorption and digestion of the body, and the intestinal mucosal barrier also plays an indispensable role.
LI Xu-nan, CHEN Xiu-mei, PENG Si-bo, LIN Yun-jie, JIN Xiao-yan, SUN Jia-xin, WANG Gui-qin   +6 more
doaj  

Estrogen deficiency aggravates fluoride-induced small intestinal mucosa damage and junctional complexes proteins expression disorder in rats

Ecotoxicology and Environmental Safety, 2022
To investigate the effect of estrogen deficiency on the small intestinal mucosal barrier induced by fluoride (F), F exposure models of ovariectomy (OVX) rats (surgically removed ovaries) and non-OVX rats (normal condition) were established by adding ...
Ye Jin, Xiao-ying Gao, Jing Zhao, Wei-shun Tian, Yu-ling Zhang, Er-jie Tian, Bian-hua Zhou, Hong-wei Wang   +7 more
doaj   +1 more source

Sulfation‐Tunable Peptide‐Glycosaminoglycan Hydrogels for Hematopoietic Stem and Progenitor Cell Expansion

Advanced Functional Materials, EarlyView.
Co‐assembly of rationally designed glycosaminoglycan‐binding peptides with sulfated glycosaminoglycans yields supramolecular hydrogels with tunable mechanics and matrix‐mediated cytokine retention. The glycosaminoglycans thereby act as cofactors, driving a coil‐to‐β‐sheet transition that triggers gelation.
Shirel Veretnik, Prannoy Seth, Maximilian Fusenig, Jens Friedrichs, Nicole Fertala, Passant Atallah, Uwe Freudenberg, Ayala Lampel, Carsten Werner   +8 more
wiley   +1 more source

The Microbiome Activates CD4 T-cell–mediated Immunity to Compensate for Increased Intestinal PermeabilitySummary

Cellular and Molecular Gastroenterology and Hepatology, 2017
Background & Aims: Despite a prominent association, chronic intestinal barrier loss is insufficient to induce disease in human subjects or experimental animals.
Karen L. Edelblum, Gil Sharon, Gurminder Singh, Matthew A. Odenwald, Anne Sailer, Severine Cao, Sarina Ravens, Irene Thomsen, Kamal El Bissati, Rima McLeod, Chen Dong, Sandeep Gurbuxani, Immo Prinz, Sarkis K. Mazmanian, Jerrold R. Turner   +14 more
doaj   +1 more source

A Fully Defined GelMA‐Based Matrix Allows Fine Tuning of Tissue‐Relevant Biomechanical and Biochemical Cues for Organoid Culture

Advanced Healthcare Materials, EarlyView.
A fully defined GelMA‐based ECM platform integrates tunable tissue‐relevant stiffness with laminin–entactin biochemical supplementation to support mouse small intestinal organoid growth. Coordinated control of mechanical and biochemical cues promotes robust proliferation, budding morphogenesis, differentiation, and passaging, providing a reproducible ...
Junyi Liu, Su Su Htwe, Lay Poh Tan, Yen Choo   +3 more
wiley   +1 more source

Maintenance of intestinal homeostasis by mucosal barriers

Inflammation and Regeneration, 2018
Background The intestine is inhabited by a tremendous number of microorganisms, which provide many benefits to nutrition, metabolism and immunity. Mucosal barriers by intestinal epithelial cells make it possible to maintain the symbiotic relationship ...
Ryu Okumura, Kiyoshi Takeda
doaj   +1 more source

Nanomaterial Strategies for Pulmonary Delivery of Immunotherapeutics in Lung Cancer Treatment

Advanced Healthcare Materials, EarlyView.
Inhalable immunotherapeutic nanomedicines enable organ‐selective immune modulation by overcoming pulmonary delivery barriers and concentrating therapy within lung tumors. This Review defines how nanomaterial properties govern airway deposition, retention, cellular partitioning, and immune activation across vaccines, checkpoint blockade, STING agonists,
Han Zhang, Wei Tang
wiley   +1 more source

Hesperidin enhances intestinal barrier function in Caco‐2 cell monolayers via AMPK‐mediated tight junction‐related proteins

FEBS Open Bio, 2023
The intestinal epithelium is a single‐cell layer on the mucosal surface that absorbs food‐derived nutrients and functions as a barrier that protects mucosal integrity.
Ha‐Young Park, Jin‐Hee Yu
doaj   +1 more source