Results 111 to 120 of about 29,322 (305)

Long-term culture of intestinal cell progenitors: an overview of their development, application, and associated technologies [PDF]

, 2016
Purpose of Review Long-term culture of adult progenitor cells in 3D is a recently emerging technology that inhabits the space between 2D cell lines and organ slice culture.
Hollins, Andrew John, Parry, Lee
core   +1 more source

Development of a Synthetic 3D Platform for Compartmentalized Kidney In Vitro Disease Modeling

Advanced Healthcare Materials, EarlyView.
A fully synthetic, compartmentalized 3D kidney disease model is introduced. The kidney model combines a PEG‐based hydrogel matrix with anisotropic, enzymatically degradable rod‐shaped microgels to spatially arrange a triple co‐culture of key renal epithelial, endothelial, and fibroblast cells.
Ninon Möhl, Daphne Bouwens, Johanna Abele, Aline Hans, Tanja Topic, Daniel Günther, Jitske Jansen, Rafael Kramann, Laura De Laporte   +8 more
wiley   +1 more source

Bladder-cancer-associated mutations in RXRA activate peroxisome proliferator-activated receptors to drive urothelial proliferation [PDF]

, 2017
RXRA regulates transcription as part of a heterodimer with 14 other nuclear receptors, including the peroxisome proliferator-activated receptors (PPARs).
Arora, Vivek K, Bolzenius, Jennifer, Bowman, Gregory R, Chu, Clarence E, Halstead, Angela M, Kapadia, Chiraag D, Schriefer, Andrew, Wartman, Lukas D   +7 more
core   +2 more sources

Highly Tunable and Cell‐Remodelable Thiol‐ene Alginate‐Peptide Crosslinked Hydrogels to Recreate Cellular and Organoid Microenvironments for Biofabrication

Advanced Healthcare Materials, EarlyView.
Norbornene‐functionalized alginate is crosslinked with a di‐thiolated peptide sequence cleavable by cell‐secreted matrix metalloproteinases and decorated with cell‐adhesion peptides upon exposure to UV. Thyroid follicles, endometrial and intestinal organoids are encapsulated in a gentle manner with high cell viability and correct phenotype ...
Julia Fernández‐Pérez, Adrián Seijas‐Gamardo, Antonio J. Feliciano, Panagiota Kakni, Anna M. Kip, Paul Wieringa, Stefan Giselbrecht, Matthew B. Baker, Lorenzo Moroni   +8 more
wiley   +1 more source

Chicken intestinal organoids: a novel method to measure the mode of action of feed additives

Frontiers in Immunology
There is a rapidly growing interest in how the avian intestine is affected by dietary components and feed additives. The paucity of physiologically relevant models has limited research in this field of poultry gut health and led to an over-reliance on ...
Jordan Mitchell, Kate Sutton, Jeyashree Nathan Elango, Dominika Borowska, Famatta Perry, Ludovic Lahaye, Elizabeth Santin, Ryan J. Arsenault, Lonneke Vervelde   +8 more
doaj   +1 more source

Retinoic acid promotes barrier functions in human iPSC-derived intestinal epithelial monolayers

Journal of Pharmacological Sciences, 2019
Vitamin A (VA) is a fat-soluble micronutrient that plays essential roles in various biological processes, including cell growth, differentiation, and apoptosis. In the intestine, VA are known to promote mucosal homeostasis and immunity.
Shigeru Yamada, Yasunari Kanda
doaj   +1 more source

A cancer rainbow mouse for visualizing the functional genomics of oncogenic clonal expansion. [PDF]

, 2019
Field cancerization is a premalignant process marked by clones of oncogenic mutations spreading through the epithelium. The timescales of intestinal field cancerization can be variable and the mechanisms driving the rapid spread of oncogenic clones are ...
Agarwal, Pankaj, Barak, Larry S, Bock, Cheryl, Boone, Peter G, Borowsky, Alexander D, Cardiff, Robert D, Caron, Marc G, Flowers, Mei Lang, Ginzel, Joshua D, Lubkov, Veronica, Lyerly, H Kim, Nicholls, PJ, Roberts, Wendy L, Rochelle, Lauren K, Snyder, Joshua C, Stripp, Barry R, von Furstenberg, Richard J   +16 more
core   +1 more source

Evaluation of the Dual Impact of Nanotechnologies on Health and Environment Through Alternative Bridging Models

Advanced Healthcare Materials, EarlyView.
This review explores how alternative invertebrate and small‐vertebrate models advance the evaluation of nanomaterials across medicine and environmental science. By bridging cellular and organismal levels, these models enable integrated assessment of toxicity, biodistribution, and therapeutic performance.
Marie Celine Lefevre, Margherita Bernardeschi, Matteo Battaglini, Gianni Ciofani   +3 more
wiley   +1 more source

Lipid-mediated Wnt protein stabilization enables serum-free culture of human organ stem cells [PDF]

, 2017
Wnt signalling proteins are essential for culture of human organ stem cells in organoids, but most Wnt protein formulations are poorly active in serum-free media.
Begthel, H. (Harry), Berge, D. (Derk) ten, Braakman, E. (Eric), Clevers, H.C. (Hans), Cornelissen, J.J. (Jan), Cruz, L.J. (Luis J.), Hui, L. (Lijian), Jonge, J. (Jeroen) de, Laan, L.J.W. (Luc) van der, Mastrobattista, E., Tüysüz, N. (Nesrin), Van Bloois, L. (Louis), Van Den Brink, S. (Stieneke), Verstegen, M.M.A. (Monique), Vries, R.G.J. (Robert)   +14 more
core   +3 more sources

A New 3D Colon on a Chip to Decipher the Influence of Mechanical Forces on the Physiological Cellular Ecosystem

Advanced Healthcare Materials, EarlyView.
To dissect how mechanical forces influence intestinal physiology, we developed a stretchable 3D colon‐on‐chip that integrates tunable topography, stiffness and peristalsis‐like motion within a physiologically relevant microenvironment. We showed that stretching is a dominant factor governing epithelial behavior, markedly enhancing proliferation and ...
Moencopi Bernheim‐Dennery, Lauriane Gérémie, Julie Brun, Lucas Chassatte, Giacomo Gropplero, Réda Bouras, Jieun Choo, Bertrand Cinquin, Alba Marcellan, Danijela Matic Vignjevic, Stéphanie Descroix   +10 more
wiley   +1 more source