Results 121 to 130 of about 29,322 (305)

Prostaglandin E2 promotes intestinal repair through an adaptive cellular response of the epithelium [PDF]

, 2017
Adaptive cellular responses are often required during wound repair. Following disruption of the intestinal epithelium, wound‐associated epithelial (WAE) cells form the initial barrier over the wound.
Lai, Chin-Wen, Malvin, Nicole P, Miyoshi, Hiroyuki, Ryu, Stacy H, Sonnek, Naomi M, Stappenbeck, Thaddeus S, VanDussen, Kelli L, Wang, Yi   +7 more
core   +2 more sources

Subtle deregulation of the Wnt-signalling pathway through loss of Apc2 reduces the fitness of intestinal stem cells [PDF]

, 2018
The importance of the Wnt-signaling pathway on the regulation and maintenance of the intesti- nal stem cell (ISC) population is well recognized. However, our current knowledge base is founded on models using systems of gross deregulation of the Wnt ...
Clarke, Alan, Daly, Carl, James, Rhiannon, Reed, Karen, Taylor, Elaine, Young, Madeleine   +5 more
core   +1 more source

Cancer Cells Traverse Faster in Confined Space by Modifying Vimentin filaments With Nuclear Deformation and Promoting the Growth of Desired Tumor Spheroids

Advanced Materials Interfaces, EarlyView.
This study demonstrates how the Vimentin intermediate (VIM) filaments distribution/density regulates the attainment of different migration modes through cytoskeleton rearrangement and controls the nuclear morphology in migrating cells under physical confinement, which facilitates the faster traversing of those cells and the growth of post‐migration ...
Md Kowsar Alam, Jiao Zhai, Heng Zou, Yu Chen, Michael Yang   +4 more
wiley   +1 more source

Development of Artificial Sebaceous Gland‐Integrated In Vitro Human Skin Model

Advanced Materials Interfaces, EarlyView.
Uniform 3D artificial sebaceous gland spheroids, termed SebaSpheres, are generated at high throughput using a microfluidic platform and structurally integrated into a collagen‐based skin construct containing fibroblasts and keratinocytes. This work presents a modular and scalable fabrication and integration strategy for incorporating sebaceous gland ...
Daeun Ryu, Hyewon Noh, Jimin Son, Haejung Lee, Bo Mi Kang, Chong Won Choi, Jong Hwan Sung, Jae Jung Kim   +7 more
wiley   +1 more source

Mule Regulates the Intestinal Stem Cell Niche via the Wnt Pathway and Targets EphB3 for Proteasomal and Lysosomal Degradation [PDF]

, 2018
The E3 ubiquitin ligase Mule is often overexpressed in human colorectal cancers, but its role in gut tumorigenesis is unknown. Here, we show in vivo that Mule controls murine intestinal stem and progenitor cell proliferation by modulating Wnt signaling ...
Brauer, Patrick M., Cairns, Robert, Chio, Iok In Christine, Clevers, Hans, Cox, Maureen A., Dominguez-Brauer, Carmen, Elia, Andrew J., Fortin, Jérôme M., Haight, Jillian, Hao, Zhenyue, Inoue, Satoshi, Mak, Tak W., Mana, Miyeko, Marques, Ana, Nechanitzky, Robert, Pollett, Aaron, Reardon, Colin, Sabatini, David, Sato, Toshiro, Sheng, Yi, Silvester, Jennifer, Tworzyanski, Leanne, van Es, Johan H., Wakeham, Andrew, Yilmaz, Omer   +24 more
core   +1 more source

Multiplexed Luminal Tissue Constructs with Reconfigurable Barriers for Dynamic Modeling of Multi‐Tissue Interactions

Advanced Materials Technologies, EarlyView.
This study describes the fabrication of arrays of luminal tissue constructs for 3D luminal tissue modeling. An oil or media‐filled reservoir between constructs serves as a liquid barrier or bridge to regulate communication between lumens within the array for modeling multi‐tissue interactions in vitro. Abstract Cell‐lined luminal structures are crucial
Mouhita Humayun, José A. Jiménez‐Torres, Chao Li, Jose M. Ayuso, Karina Lugo‐Cintron, Joseph Ulbrich, Benjamin Myers, Sheena C. Kerr, Adeel Ahmed, David J. Beebe   +9 more
wiley   +1 more source

Functional characteristics of a pig 2D intestinal organoid model as an in vitro platform for nutritional studies

Journal of Animal Science and Technology
Intestinal epithelial cell lines have been widely used in the field of biomedical and livestock research, and recently, the use of organoid systems has been attempted.
Sang Seok Joo, Bon-Hee Gu, Eunbyeol Lee, Eunseon Oh, Minji Kim, Hyunjung Jung, Myunghoo Kim   +6 more
doaj   +1 more source

Identification of Lgr5-Independent Spheroid-Generating Progenitors of the Mouse Fetal Intestinal Epithelium

Cell Reports, 2013
Immortal spheroids were generated from fetal mouse intestine using the culture system initially developed to culture organoids from adult intestinal epithelium.
Roxana C. Mustata, Gabriela Vasile, Valeria Fernandez-Vallone, Sandra Strollo, Anne Lefort, Frédérick Libert, Daniel Monteyne, David Pérez-Morga, Gilbert Vassart, Marie-Isabelle Garcia   +9 more
doaj   +1 more source

Long-term culture captures injury-repair cycles of colonic stem cells [PDF]

, 2019
The colonic epithelium can undergo multiple rounds of damage and repair, often in response to excessive inflammation. The responsive stem cell that mediates this process is unclear, in part because of a lack of in vitro models that recapitulate key ...
Chen, Feidi, Cheng, Jiye, Chiang, I-Ling, Fujii, Satoru, Gordon, Jeffrey I, Han, Nathan D, Janova, Hana, Lai, Chin-Wen, Liu, Ta-Chiang, Lu, Qiuhe, Muegge, Brian D, Ohara, Takahiro E, Sibley, L David, Stappenbeck, Thaddeus S, VanDussen, Kelli L, Ver Heul, Aaron, Wang, Yi, Whitehurst, Charles E, Wu, Renee, Xiong, Shanshan   +19 more
core   +1 more source

mTORC1 in the Paneth cell niche couples intestinal stem cell function to calorie intake [PDF]

, 2012
How adult tissue stem and niche cells respond to the nutritional state of an organism is not well understood. Here we find that Paneth cells, a key constituent of the mammalian intestinal stem-cell (ISC) niche, augment stem-cell function in response to ...
Abdulmetin Dursun, Atul K. Bhan, BD Simons, C Beard, CM McCay, D Nakada, DA Guertin, David M. Sabatini, DD Sarbassov, DE Cohen, DT Breault, Dudley W. Lamming, E Sangiorgi, G. Petur Nielsen, GG Altmann, HJ Snippert, J Chen, Khristian E. Bauer-Rowe, Kivanc Birsoy, L Bondolfi, L Zhu, Lawrence R. Zukerberg, LE O’Brien, LG van der Flier, M Podesta, Mari Mino-Kenudson, Martin Selig, N Barker, N Takeda, NY Kalaany, OH Yilmaz, OH Yilmaz, Pekka Katajisto, RP Ertl, S Dunel-Erb, S Hempenstall, S Sengupta, Shomit Sengupta, SR Spindler, T Sato, T Sato, V Marsh, V. Onur Yilmaz, Vikram Deshpande, Yetis Gültekin, Ömer H. Yilmaz   +45 more
core   +2 more sources