Results 211 to 220 of about 29,322 (305)

Primary human intestinal organoids with biallelic UNC45A variants suggest role of cystic fibrosis transmembrane conductance regulator in pathogenesis of UNC45A-related intestinal disorder. [PDF]

J Pediatr Gastroenterol Nutr
Foster AR, G N, Harris R, Zilbauer M, Ross A.   +4 more
europepmc   +1 more source

L-WRN conditioned medium for gastrointestinal epithelial stem cell culture shows replicable batch-to-batch activity levels across multiple research teams [PDF]

, 2019
Sonnek, Naomi M, Stappenbeck, Thaddeus S, VanDussen, Kelli L   +2 more
core   +1 more source

Interpretation of in vitro concentration‐response data for risk assessment and regulatory decision‐making: Report from the 2022 IWGT quantitative analysis expert working group meeting

Environmental and Molecular Mutagenesis, EarlyView.
Abstract Quantitative risk assessments of chemicals are routinely performed using in vivo data from rodents; however, there is growing recognition that non‐animal approaches can be human‐relevant alternatives. There is an urgent need to build confidence in non‐animal alternatives given the international support to reduce the use of animals in toxicity ...
Marc A. Beal, Guangchao Chen, Kerry L. Dearfield, Min Gi, Bhaskar Gollapudi, Robert H. Heflich, Katsuyoshi Horibata, Alexandra S. Long, David P. Lovell, Barbara L. Parsons, Stefan Pfuhler, John Wills, Andreas Zeller, George Johnson, Paul A. White   +14 more
wiley   +1 more source

Cellular landscape of avian intestinal organoids revealed by single cell transcriptomics. [PDF]

Sci Rep
Sun J, Borowska D, Furniss JJ, Sutton K, Macqueen DJ, Vervelde L.   +5 more
europepmc   +1 more source

Precision therapies for genetic epilepsies in 2025: Promises and pitfalls

Epilepsia Open, EarlyView.
Abstract By targeting the underlying etiology, precision therapies offer an exciting paradigm shift to improve the stagnant outcomes of drug‐resistant epilepsies, including developmental and epileptic encephalopathies. Unlike conventional antiseizure medications (ASMs) which only treat the symptoms (seizures) but have no effect on the underlying ...
Shuyu Wang, Emilio Perucca, Samuel F. Berkovic, Piero Perucca   +3 more
wiley   +1 more source

Development of Sheep Intestinal Organoids for Studying Deoxynivalenol-Induced Toxicity. [PDF]

Int J Mol Sci
Wang H, He X, Zhang M, Fan N, Yang Z, Shen T, Guo J, Song Y, Cao G, Liu Y, Li X, Nashun B.   +11 more
europepmc   +1 more source

When Rare Is Not Small: Amyotrophic Lateral Sclerosis Initiatives and Therapy

Exploration, EarlyView.
In the precision‐medicine era, rare diseases must not be sidelined in translational infrastructure. The Mr. Cai Lei—led “Ice‐Breaking Team” turns an amyotrophic lateral sclerosis patient community into a sustainable ecosystem, realigning philanthropy, data, and research and development to reshape rare‐disease pipelines and guide precision therapies ...
Yang Liu, Xue Xia, Yingfang Chen, Haoying Yang, Xiaochen Chen, Lei Cai, Bingyang Shi   +6 more
wiley   +1 more source

Combination therapy using intestinal organoids and their extracellular vesicles for inflammatory bowel disease complicated with osteoporosis. [PDF]

J Orthop Translat
Wang M, Li R, Sheng S, Dong Z, Bai L, Wang X, Wang J, Lai Y, Chen X, Gao J, He C, Liu H, Su J.   +12 more
europepmc   +1 more source

Insights into Modeling Inflammatory Bowel Disease from Stem Cell Derived Intestinal Organoids. [PDF]

Stem Cell Rev Rep
Zhao Q, Shao M, Ma L, Zhou R.
europepmc   +1 more source

Intestinal organoids from F508del patients

Intestinal organoids from F508del ...
openaire   +1 more source