Results 231 to 240 of about 29,322 (305)

BIOME cohort: Multi‐system microbiome dynamics and clinical outcomes in massive burn injury patients

iMeta, EarlyView.
Massive burn injuries (MBIs) are associated with high mortality and disability rates, primarily due to microbial‐driven sepsis from extensive skin barrier loss and subsequent scar formation. This makes MBI a compelling model for studying multi‐system microbial dysbiosis following skin barrier destruction.
Runzhi Huang, Yixu Li, Xiaoliang Li, Xulin Chen, Gang Xu, Shurun Huang, Weixi Yang, Xiaodong Li, Haiming Xin, Jianqiang Jiao, Hui Chen, Yuguo Xie, Peng Duan, Wenjun Liu, Xiangdong Deng, Zongyu Li, Yiping Xiu, Jiansheng Zheng, Rujun Chen, Zhaohong Chen, Xingang Wang, Xiaojian Li, Gaoxing Luo, Yi Zhang, Hongyan Zhang, Shichu Xiao, Liang Xiao, Ruijin Guo, Jie Zhang, Xiaofei Ye, Hongtai Tang, Qiao Zuo, Bin Qu, Bingwei Sun, Changhong Lu, Chengliang Deng, Deyi Zheng, Geng Ji, Haisheng Li, Haizhou Yu, Hua Zhou, Jian Wu, Lanjun Nie, Lei Wang, Pihong Zhang, Qingfu Zhang, Shengwu Chao, Sisi Yang, Xianglin Ding, Xiangsheng Ding, Ying Yan, Jiangyong Shen, Yongjian Zhao, Yunchuan Pan, Yunbiao Shen, Yu Zhang, Zhihui Yao, Zhe Cheng, Jiangfan Xie, Zhigang Chu, Shijie Li, Long Xu, Xiuming Yang, Sujie Xie, Hanlin Sun, Shuyuan Xian, Dezhi Han, Maolong Dong, Chengde Xia, Peng Luo, Yongming Yao, Zhaofan Xia, Shizhao Ji   +72 more
wiley   +1 more source

<i>Saccharomyces boulardii</i> CNCM I-745 Supernatant Improves Markers of Gut Barrier Function and Inflammatory Response in Small Intestinal Organoids. [PDF]

Pharmaceuticals (Basel)
Filipe Rosa L, Gonda S, Roese N, Bischoff SC.   +3 more
europepmc   +1 more source

Beyond a Conduit: The Evolution of Functional Biliary Stents From Active Intervention to Enabling Platforms

iNew Medicine, EarlyView.
This review traces the evolution of functional biliary stents, outlining the paradigm shift from “active intervention” strategies that target stent failure to next‐generation “enabling platforms.” These platforms leverage biodegradable materials, 3D/4D printing, and smart sensors to achieve personalized, regenerative, and theranostic solutions ...
Muhan Li, Xu Liu, Xin Ye, Zhixia Dong, Xinjian Wan   +4 more
wiley   +1 more source

Correction: Establishment and Culture of Human Intestinal Organoids Derived from Adult Stem Cells. [PDF]

Curr Protoc
Pleguezuelos-Manzano C, Puschhof J, van den Brink S, Geurts V, Beumer J, Clevers H.   +5 more
europepmc   +1 more source

Targeting GRP78 and the Proteostasis Network to Break the Therapeutic Ceiling in Neuroendocrine Prostate Cancer

iNew Medicine, EarlyView.
ABSTRACT HSPA5 (also known as GRP78/BiP) is a master regulator of the endoplasmic reticulum (ER) stress response and a key node in the proteostasis network. In neuroendocrine prostate cancer (NEPC), an aggressive, therapy‐refractory lineage that emerges under pressure from androgen receptor (AR) directed therapies, GRP78 is upregulated and co‐opted to ...
Amos Olalekan Akinyemi, Md Rakibul Alam, Mithu Howlader, Mohammad Esfini Farahani, Lixiang Gu, Chun Li, Chripus Ngule, Kevin Fulp, Bolaji Owoyemi, Xinyi Wang, Samuel Nwadialo, Fatemeh Selani, Makumba Esoe, Obaleye Oluwafunminiyi, Zhiguo Li   +14 more
wiley   +1 more source

Macrophage-augmented intestinal organoids model virus-host interactions in enteric viral diseases and facilitate therapeutic development. [PDF]

Nat Commun
Xu G, Zhou J, Liu K, Wang Y, Tsikari T, Qin F, van den Hil F, Boor PPC, Ayada I, de Vries AC, Li J, Jiang S, Offermans DM, Kainov DE, Janssen HLA, Peppelenbosch MP, Bijvelds MJC, Wang W, Orlova VV, Pan Q, Li P.   +20 more
europepmc   +1 more source

Schisantherin A: Remodeling Gut Microbiota to Activate the Gut–Immune–Neural–Adipose Axis for Thermogenesis

iNew Medicine, EarlyView.
ABSTRACT The global obesity epidemic necessitates safe and effective strategies to enhance energy expenditure. Schisantherin A (Sin A), a lignan derived from Schisandra chinensis, has demonstrated metabolic benefits, yet its systemic mechanism remains unclear.
Ling Yin
wiley   +1 more source

Organoids and organ‐on‐a‐chip models for investigating the pathophysiology of the human reproductive system

Interdisciplinary Medicine, EarlyView.
Organoids and organ‐on‐a‐chips are advancing reproductive system research. In the female reproductive system, applications include cancer organoid models, placental chips, and hormone simulation models. For the male reproductive system, research focuses on drug resistance mechanisms, co‐culture platforms, and infertility studies. These refined in vitro
Hongqi Zhang, Shiwen Deng, Fangfang Jin, Jiayao Qu, Xiang Fan, Peng Chen, Xinrong Fan   +6 more
wiley   +1 more source

Tannic Acid and Ethacridine Lactate Attenuate Markers of Stress-Induced Intestinal Barrier Dysfunctions in Murine Small Intestinal Organoids. [PDF]

Biomolecules
Filipe Rosa L, Gonda S, Roese N, Bischoff SC.   +3 more
europepmc   +1 more source

Gut microbiome‐derived metabolites show promise in cancer research and therapy

Interdisciplinary Medicine, EarlyView.
The metabolites produced by the gut microbiome, which are subject to regulation by multiple factors, play a pivotal role in the progression of various types of cancer. These metabolites not only function as potential biomarkers for the early detection and monitoring of tumor development, but also actively participate in cancer therapeutic processes ...
Kangjie Yang, Yifan Wang, Daolin Tang, Peilong Li, Lutao Du   +4 more
wiley   +1 more source