Results 251 to 260 of about 29,322 (305)

TGF-β signaling redirects Sox11 gene regulatory activity to promote partial EMT and collective invasion of oncogenically transformed intestinal organoids. [PDF]

Oncogenesis
Teng YH, Appiah B, Andrieux G, Schrempp M, Rose K, Hofmann AS, Ku M, Beyes S, Boerries M, Hecht A.   +9 more
europepmc   +1 more source

Nature Inspired Delivery Vehicles for CRISPR‐Based Genome Editing

Small, EarlyView.
The review highlights nature‐inspired nanocarriers for CRISPR delivery, emphasizing viral vectors, extracellular vesicles, liposomes, and lipid nanoparticles. It discusses their roles in improving specificity, minimizing immunogenicity, and overcoming barriers in genome editing. Recent advancements, challenges, and therapeutic applications are explored,
Elizabeth Maria Clarissa, Mamata Karmacharya, Hyunmin Choi, Sumit Kumar, Yoon‐Kyoung Cho   +4 more
wiley   +1 more source

Potential consequences of phototoxicity on cell function during live imaging of intestinal organoids. [PDF]

PLoS One
Yokoi Y, Nakamura R, Ohira S, Takemi S, Ayabe T, Nakamura K.   +5 more
europepmc   +1 more source

Brain Pericytes and Wnt/β‐Catenin Signaling Induce Functional Blood–Brain Barrier Phenotype in Human iPSC‐Derived Model

Small Methods, EarlyView.
This study shows that human iPSC‐derived endothelial cells acquire a functional blood–brain barrier phenotype when co‐cultured with brain pericytes and stimulated with CHIR‐99021, a Wnt/β‐catenin activator. This model recapitulates key barrier properties, inflammatory responses, and transcriptomic features of the native human BBB, offering new ...
Henrique Nogueira Pinto, Nine R. Kok, Philipp C. Hauger, Manon Karsten‐van Diepen, Michael de Kok, Nanne J. Paauw, Susanne M. A. van der Pol, Joline P. Nugteren‐Boogaard, Peter L. Hordijk, Stephanie D. Beekhuis‐Hoekstra, Susan Gibbs, Nienke M. de Wit, Helga E. de Vries   +12 more
wiley   +1 more source

Tofacitinib Uptake by Patient-Derived Intestinal Organoids Predicts Individual Clinical Responsiveness. [PDF]

Gastroenterology
Jang KK, Hudesman D, Jones DR, Loke P, Axelrad JE, Cadwell K, Tofacitinib Working Group.   +6 more
europepmc   +1 more source

Cellular Stress, Inflammation and Barrier Damage in Gut Epithelial Cells Caused by Aspartame

Allergy, EarlyView.
This study shows that aspartame, at dietary‐relevant doses, induces cytotoxicity, cellular distress associated with endoplasmic reticulum stress, oxidative stress, DNA replication and repair mechanism disturbance culminating in epithelial barrier damage.
Yagiz Pat, Duygu Yazici, Can Zeyneloglu, Huseyn Babayev, Sena Ardicli, Asuncion Garci‐Sanchez, Xiangting Bu, Anja Heider, Oliva Giannelli Viscardi, Lihong Chang, Sheri Simmons, Anthony Almada, Christine Avena, Tye Jensen, Raja Dhir, Ismail Ogulur, Cezmi A. Akdis   +16 more
wiley   +1 more source

Chicken intestinal organoids reveal polarity-dependent replication dynamics and immune responses of low pathogenic avian influenza viruses. [PDF]

Poult Sci
Shin DL, Tsai YB, Hsu SH, Liang CC, Wu NH.   +4 more
europepmc   +1 more source

Allergic Sensitization to Inhalant Allergens in the Upper Respiratory Tract—the B Cell Side

Allergy, EarlyView.
ABSTRACT Allergic diseases are on the rise worldwide, driven by respiratory epithelial barrier dysfunction that promotes sensitization to inhalant allergens such as pollen, dust mites, pet dander, and fungal spores. These antigens trigger IgE‐mediated immune responses that lead to diseases such as allergic rhinitis (AR) and asthma.
Ola Grimsholm, Mohammed Zghaebi, Bita Hambrecht, Tanja Kalic, Christopher C. Udoye, Rudolf Manz, Barbara Bohle, Katarzyna M. Sitnik, Julia Eckl‐Dorna, Heimo Breiteneder   +9 more
wiley   +1 more source

Intestinal organoids to model Salmonella infection and its impact on progenitors. [PDF]

Sci Rep
Yan J, Racaud-Sultan C, Pezier T, Edir A, Rolland C, Claverie C, Burlaud-Gaillard J, Olivier M, Velge P, Lacroix-Lamandé S, Vergnolle N, Wiedemann A.   +11 more
europepmc   +1 more source

3D fluorescence staining and confocal imaging of low amount of intestinal organoids (enteroids): Protocol accessible to all. [PDF]

PLoS One
Toulehohoun AG, Bouzin C, Daumerie A, Maccioni L, Stärkel P.   +4 more
europepmc   +1 more source