Results 261 to 270 of about 29,322 (305)

Bacterial attachment and junctional transport function in induced apical-out polarized and differentiated canine intestinal organoids. [PDF]

Front Vet Sci
Yoshida S, Nakazawa M, Kawasaki M, Ambrosini YM.   +3 more
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Adenine base editing with engineered virus-like particles rescues the <i>CFTR</i> mutation G542X in patient-derived intestinal organoids. [PDF]

iScience
Nicosia L, Pranke I, Latorre RV, Murray JB, Lonetti L, Cavusoglu-Doran K, Dreano E, Costello JP, Carroll M, Melotti P, Sorio C, Sermet-Gaudelus I, Scallan MF, Harrison PT.   +13 more
europepmc   +1 more source

Anisakis extracellular vesicles elicit immunomodulatory and potentially tumorigenic outcomes on human intestinal organoids. [PDF]

Parasit Vectors
Bellini I, Scribano D, Ambrosi C, Chiovoloni C, Rondón S, Pronio A, Palamara AT, Pietrantoni A, Kashkanova A, Sandoghdar V, D'Amelio S, Cavallero S.   +11 more
europepmc   +1 more source

Primary human intestinal organoids recapitulate enteric infection of monkeypox virus and enable scalable drug discovery

Li P, Zhou J, Wang Y, Wang X, Xu G, Schraauwen R, Gonçalves AM, de Henau C, Incitti R, Offermans DM, de Vries AC, Kainov DE, Alam I, Raymond K, Duarte-Neto AN, Bijvelds MJC, Pan Q.   +16 more
europepmc   +1 more source

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Potential Application of Intestinal Organoids in Intestinal Diseases

Stem Cell Reviews and Reports, 2023
To accurately reveal the scenario and mecahnism of gastrointestinal diseases, the establishment of in vitro models of intestinal diseases and drug screening platforms have become the focus of attention. Over the past few decades, animal models and immortalized cell lines have provided valuable but limited insights into gastrointestinal research.
Wenxiu Liu, Qian Wang, Yanrui Bai, Han Xiao, Zhunduo Li, Yan Wang, Qi Wang, Jing Yang, Hui Sun   +8 more
openaire   +2 more sources

Intestinal stem cells and intestinal organoids

Journal of Genetics and Genomics, 2020
The intestinal epithelium is one of the most rapidly renewing tissues, which is fueled by stem cells at the base of the crypts. Strategies of genetic lineage tracing and organoids, which capture major features of original tissues, are powerful avenues for exploring the biology of intestinal stem cells in vivo and in vitro, respectively. The combination
Qian, Zhao, Jiawei, Guan, Xia, Wang
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Intestinal organoids: roadmap to the clinic

American Journal of Physiology-Gastrointestinal and Liver Physiology, 2021
Recent advances in intestinal organoid research, along with encouraging preclinical proof-of-concept studies, have revealed significant therapeutic potential for induced pluripotent stem cell (iPSC)-derived organoids in the healing and replacement of severely injured or diseased bowel (Finkbeiner et al. Biol Open 4: 1462–1472, 2015; Kitano et al.
Magdalena Kasendra, Misty Troutt, Taylor Broda, W. Clark Bacon, Timothy C. Wang, Joyce C. Niland, Michael A. Helmrath   +6 more
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Small Intestinalization of Colon Using Ileum Organoids

Trends in Cell Biology, 2021
Given the mismatch in size and morphology of intestinal organoids with native intestine, their application in intestinal segment regeneration has yet to be achieved. By engrafting ileal organoids in epithelium-removed colon, Sugimoto et al. recently constructed transplantable colonic segments with functional ileal epithelium and a subepithelial ...
Jinjian, Huang, Ziyan, Xu, Jianan, Ren
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Intestinal organoids in infants and children

Pediatric Surgery International, 2019
Recent advances in culturing of intestinal stem cells and pluripotent stem cells have led to the development of intestinal organoids. These are self-organizing 3D structures, which recapitulate the characteristics and physiological features of in vivo intestinal epithelium.
Sinobol, Chusilp, Bo, Li, Dorothy, Lee, Carol, Lee, Paisarn, Vejchapipat, Agostino, Pierro   +5 more
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Generation and Manipulation of Rat Intestinal Organoids

Journal of Visualized Experiments, 2023
When using organoids to assess physiology and cell fate decisions, it is important to use a model that closely recapitulates in vivo contexts. Accordingly, patient-derived organoids are used for disease modeling, drug discovery, and personalized treatment screening.
Eleanor, Zagoren, Anderson K, Santos, Nadia A, Ameen, Kaelyn, Sumigray   +3 more
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