Cellular aspect ratio and cell division mechanics underlie the patterning of cell progeny in diverse mammalian epithelia. [PDF]
, 2018 Cell division is essential to expand, shape, and replenish epithelia. In the adult small intestine, cells from a common progenitor intermix with other lineages, whereas cell progeny in many other epithelia form contiguous patches.
Castillo-Azofeifa, David +7 more
core +1 more source
LRH-1 mitigates intestinal inflammatory disease by maintaining epithelial homeostasis and cell survival. [PDF]
, 2018 Epithelial dysfunction and crypt destruction are defining features of inflammatory bowel disease (IBD). However, current IBD therapies targeting epithelial dysfunction are lacking.
Bayrer, James R +8 more
core +2 more sources
Intestinal organoids for modelling intestinal development and disease [PDF]
Philosophical Transactions of the Royal Society B: Biological Sciences, 2018 Gastrointestinal diseases are becoming increasingly prevalent in developed countries. Immortalized cells and animal models have delivered important but limited insight into the mechanisms that initiate and propagate these diseases. Human-specific models of intestinal development and disease are desperately needed that can recapitulate structure and ...
Kathryn L. Fair +2 more
openaire +2 more sources
Stem cell-derived intestinal organoids: a novel modality for IBD
Cell Death Discovery, 2023 The organoids represent one of the greatest revolutions in the biomedical field in the past decade. This three-dimensional (3D) micro-organ cultured in vitro has a structure highly similar to that of the tissue and organ.
Cheng-mei Tian +10 more
doaj +1 more source
Control of intestinal stem cell function and proliferation by mitochondrial pyruvate metabolism. [PDF]
, 2017 Most differentiated cells convert glucose to pyruvate in the cytosol through glycolysis, followed by pyruvate oxidation in the mitochondria. These processes are linked by the mitochondrial pyruvate carrier (MPC), which is required for efficient ...
A Ootani +86 more
core +1 more source
Structuring Human Intestinal Organoids [PDF]
Biophysical Journal, 2016 Organoids are millimeter-scale tissues that replicate the structure and function of naturally formed organs. These tissues are grown in the lab through the directed differentiation of stem cells and have potential uses in biotechnology. Human intestinal organoids (HIO's) serve as a model system for the small intestine and offer potential in ...
Sidar, Barkan +4 more
openaire +1 more source
Crosstalk between H9N2 avian influenza virus and crypt-derived intestinal organoids
Veterinary Research, 2017 The spread of Avian influenza virus via animal feces makes the virus difficult to prevent, which causes great threat to human health. Therefore, it is imperative to understand the survival and invasion mechanism of H9N2 virus in the intestinal mucosa. In
Lulu Huang +4 more
doaj +1 more source
Caspase-8 controls the gut response to microbial challenges by Tnf-alpha-dependent and independent pathways [PDF]
, 2014 Objectives: Intestinal epithelial cells (IEC) express toll-like receptors (TLR) that facilitate microbial recognition. Stimulation of TLR ligands induces a transient increase in epithelial cell shedding, a mechanism that serves the antibacterial and ...
Basic, Marijana +12 more
core +3 more sources
Epithelial cell specific Raptor is required for initiation of type 2 mucosal immunity in small intestine [PDF]
, 2017 Intestinal tuft cells are one of 4 secretory cell linages in the small intestine and the source of IL-25, a critical initiator of the type 2 immune response to parasite infection. When Raptor, a critical scaffold protein for mammalian target of rapamycin
Aladegbami, Bola +6 more
core +2 more sources
Large variety in a panel of human colon cancer organoids in response to EZH2 inhibition [PDF]
, 2016 EZH2 inhibitors have gained great interest for their use as anti-cancer therapeutics. However, most research has focused on EZH2 mutant cancers and recently adverse effects of EZH2 inactivation have come to light.
Bounova, Gergana +6 more
core +1 more source