Results 31 to 40 of about 29,322 (305)

Intestinal organoids to model cystic fibrosis [PDF]

European Respiratory Journal, 2019
CF can be studied using patient-specific intestinal organoids. CFTR protein function in intestinal organoids correlates with clinical disease severity and drug testing in organoids could aid in finding drugs for people with rare CFTR mutations.https://bit.ly ...
van Mourik, Peter, Beekman, Jeffrey M., van der Ent, Cornelis K.   +2 more
openaire   +3 more sources

An individual based computational model of intestinal crypt fission and its application to predicting unrestrictive growth of the intestinal epithelium. [PDF]

, 2014
Intestinal crypt fission is a homeostatic phenomenon, observable in healthy adult mucosa, but which also plays a pathological role as the main mode of growth of some intestinal polyps.
A. Patrick Gunning, Aimee Parker, Andreu, Arber, Barker, Barker, Bashir, Berlanga-Acosta, Buczacki, Buske, Buske, Cairnie, Carmen Pin, Cheng, Cheng, Clarke, Clevers, Cummins, Cummins, Dehmer, Dekaney, Drasdo, Drasdo, Dunn, Durand, Edwards, Fauser, Galle, Hannezo, Haramis, Hirata, Humphries, Humphries, Hutter, Ian T. Johnson, Leushacke, Li, Li, Loeffler, Loeffler, Loeffler, Loeffler, Meineke, Milicic, Miyoshi, Nelson, Nelson, Ootani, Osborne, Pin, Pitt-Francis, Potten, Roth, Rothenberg, Sato, Sato, Sato, Sato, Simon R. Carding, Snippert, St Clair, Toshiro Sato, Totafurno, van Es, Wasan, Wong, Wright, Wright, Wright, Yuki Ohta   +69 more
core   +1 more source

Generation of Differentiating and Long-Living Intestinal Organoids Reflecting the Cellular Diversity of Canine Intestine

Cells, 2020
Functional intestinal disorders constitute major, potentially lethal health problems in humans. Consequently, research focuses on elucidating the underlying pathobiological mechanisms and establishing therapeutic strategies.
Nina Kramer, Barbara Pratscher, Andre M. C. Meneses, Waltraud Tschulenk, Ingrid Walter, Alexander Swoboda, Hedwig S. Kruitwagen, Kerstin Schneeberger, Louis C. Penning, Bart Spee, Matthias Kieslinger, Sabine Brandt, Iwan A. Burgener   +12 more
doaj   +1 more source

Transient PP2A inhibition alleviates normal tissue stem cell susceptibility to cell death during radiotherapy [PDF]

, 2018
Unintended outcomes of cancer therapy include ionizing radiation (IR)-induced stem cell depletion, diminished regenerative capacity, and accelerated aging.
Fabbrizi, Maria Rita, Hallahan, Dennis E., Meyer, Barbara, Misri, Sandeep, Raj, Suyash, Sharma, Girdhar G., Zobel, Cheri L.   +6 more
core   +3 more sources

Modeling Intestinal Stem Cell Function with Organoids [PDF]

International Journal of Molecular Sciences, 2021
Intestinal epithelial cells (IECs) are crucial for the digestive process and nutrient absorption. The intestinal epithelium is composed of the different cell types of the small intestine (mainly, enterocytes, goblet cells, Paneth cells, enteroendocrine cells, and tuft cells).
Toshio Takahashi, Kazuto Fujishima, Mineko Kengaku   +2 more
openaire   +2 more sources

Rho-A prenylation and signaling link epithelial homeostasis to intestinal inflammation [PDF]

, 2016
Although defects in intestinal barrier function are discussed as a key pathogenic factor in patients with inflammatory bowel diseases (IBD), the molecular pathways driving disease-specific alterations of intestinal epithelial cells (IECs) are largely ...
Alastair J.M. Watson, Arif B. Ekici, Becker, Christoph Becker, Claudia Günther, Cord Brakebusch, Distler, Gionata Fiorino, Heller, Hopkins, Imke Atreya, Kerstin Amann, Lin, Markus F. Neurath, Martin Bergö, Ohkusa, Pastorelli, Pechlivanis, Raja Atreya, Rocío López-Posadas, Silvio Danese, Stefan Tenzer, Stefan Wirtz, Stefania Vetrano, Turcotte, Ulrike Billmeier, Veronika Thonn, Zverina   +27 more
core   +1 more source

Innate immune receptor NOD2 mediates LGR5+ intestinal stem cell protection against ROS cytotoxicity via mitophagy stimulation [PDF]

, 2020
International audienceThe nucleotide-binding oligomerization domain-containing protein 2 (NOD2) agonist muramyl dipeptide (MDP), a peptidoglycan motif common to all bacteria, supports leucine-rich repeat-containing G protein-coupled receptor 5 (LGR5 ...
Deutsch, Eric, Donnadieu, Françoise, Levy, Antonin, Nigro, Giulia, Sansonetti, Philippe J., Stedman, Aline, Virgin, Herbert W.   +6 more
core   +4 more sources

Primary Intestinal Epithelial Organoid Culture

, 2020
The intestinal epithelium is known as one of the most regenerative tissues in our body. The lining of the intestine is composed of a single layer of epithelial cells generated by rapidly renewing stem cells residing at the crypt bottoms, resulting in a flow of cells to the villus tips.
Mizutani, Tomohiro, Clevers, Hans
openaire   +3 more sources

Phenotypic landscape of intestinal organoid regeneration

Nature, 2020
The development of intestinal organoids from single adult intestinal stem cells in vitro recapitulates the regenerative capacity of the intestinal epithelium1,2. Here we unravel the mechanisms that orchestrate both organoid formation and the regeneration of intestinal tissue, using an image-based screen to assay an annotated library of compounds.
Ilya Lukonin, Denise Serra, Ludivine Challet Meylan, Katrin Volkmann, Janine Baaten, Rui Zhao, Shelly Meeusen, Karyn Colman, Francisca Maurer, Michael B. Stadler, Jeremy Jenkins, Prisca Liberali   +11 more
openaire   +3 more sources

A Refined Culture System for Human Induced Pluripotent Stem Cell-Derived Intestinal Epithelial Organoids

Stem Cell Reports, 2018
Summary: Gut epithelial organoids are routinely used to investigate intestinal biology; however, current culture methods are not amenable to genetic manipulation, and it is difficult to generate sufficient numbers for high-throughput studies.
Yu Takahashi, Shintaro Sato, Yosuke Kurashima, Tomohisa Yamamoto, Shiho Kurokawa, Yoshikazu Yuki, Naoki Takemura, Satoshi Uematsu, Chen-Yi Lai, Makoto Otsu, Hiroshi Matsuno, Hideki Osawa, Tsunekazu Mizushima, Junichi Nishimura, Mikio Hayashi, Takayuki Yamaguchi, Hiroshi Kiyono   +16 more
doaj   +1 more source