Results 51 to 60 of about 29,322 (305)

Healing of Human Intestinal Organoids [PDF]

Biophysical Journal, 2016
Organoids are millimeter-scale tissues that replicate the structure and function of naturally formed organs. These tissues are grown in the lab through the directed differentiation of stem cells and have potential uses in biotechnology. Human intestinal organoids (HIO's) serve as a model system for the small intestine and offer potential in ...
Berglund, Emily A., Martinson, Jonathan N.V., Spence, Jason R., Walk, Seth T., Wilking, James N.   +4 more
openaire   +1 more source

Chicken-derived RSPO1 and WNT3 contribute to maintaining longevity of chicken intestinal organoid cultures

Scientific Reports, 2022
Intestinal organoids are advanced cellular models, which are widely used in mammalian studies to mimic and study in vivo intestinal function and host–pathogen interactions. Growth factors WNT3 and RSPO1 are crucial for the growth of intestinal organoids.
Miriam J. Oost, Adil Ijaz, Daphne A. van Haarlem, Kitty van Summeren, Francisca C. Velkers, Aletta D. Kraneveld, Koen Venema, Christine A. Jansen, Raymond H. H. Pieters, Jean Paul ten Klooster   +9 more
doaj   +1 more source

DNA Methylation Analysis Validates Organoids as a Viable Model for Studying Human Intestinal Aging. [PDF]

, 2020
Background & aimsThe epithelia of the intestine and colon turn over rapidly and are maintained by adult stem cells at the base of crypts. Although the small intestine and colon have distinct, well-characterized physiological functions, it remains ...
Coppola, Giovanni, Horvath, Steve, Jones, D Leanne, Lewis, Sophia K, Martin, Martin G, Nachun, Daniel   +5 more
core  

Targeting the tumor microenvironment in colorectal peritoneal metastases

, 2020
Peritoneal metastasis (PM) occurs in approximately one in four colorectal cancer (CRC) patients. The pathophysiology of colorectal PM remains poorly characterized. Also, the efficacy of current treatment modalities, including surgery and intraperitoneal (
Ceelen, Wim, De Wever, Olivier, Heriot, Alexander G., Narasimhan, Vignesh, Ramsay, Robert G.   +4 more
core   +1 more source

Mechanisms of parasite‐mediated disruption of brain vessels

FEBS Letters, EarlyView.
Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira, Sílvia Arroz‐Madeira, Cláudio A. Franco, Sara Silva Pereira   +3 more
wiley   +1 more source

Establishment of Epithelial Inflammatory Injury Model Using Intestinal Organoid Cultures

Stem Cells International, 2023
Intestinal epithelial dysfunction is critical in the development of inflammatory bowel disease (IBD). However, most cellular experiments related to epithelial barrier studies in IBD have been based on tumor cell line that lack a variety of intestinal ...
Chengfeng Xing, Guili Liang, Xin Yu, Anxing Zhang, Xiang Luo, Yu Liu, Zengli Tang, Bian Wu, Zhengji Song, Danfeng Lan   +9 more
doaj   +1 more source

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

Molecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici, Soheil Akbari, Ceyda Caliskan, Canan Celiker, Ozden Oz, Leman Binokay, Gökhan Karakulah, Serif Senturk, Esra Erdal   +8 more
wiley   +1 more source

Suspended hydrogel culture as a method to scale up intestinal organoids

Scientific Reports, 2023
Primary tissue-derived epithelial organoids are a physiologically relevant in vitro intestinal model that have been implemented for both basic research and drug development applications.
Julia Y. Co, Jessica A. Klein, Serah Kang, Kimberly A. Homan   +3 more
doaj   +1 more source

Understanding disruption of the gut barrier during inflammation: Should we abandon traditional epithelial cell lines and switch to intestinal organoids?

Frontiers in Immunology, 2023
Disruption of the intestinal epithelial barrier is a hallmark of mucosal inflammation. It increases exposure of the immune system to luminal microbes, triggering a perpetuating inflammatory response.
Susana Lechuga, Manuel B. Braga-Neto, Nayden G. Naydenov, Florian Rieder, Florian Rieder, Andrei I. Ivanov   +5 more
doaj   +1 more source

Cornea organoids from human induced pluripotent stem cells. [PDF]

, 2017
The cornea is the transparent outermost surface of the eye, consisting of a stratified epithelium, a collagenous stroma and an innermost single-cell layered endothelium and providing 2/3 of the refractive power of the eye. Multiple diseases of the cornea
Adams, Sheila M, Birk, David E, Chakravarti, Shukti, Foster, James W, Wahlin, Karl, Zack, Donald J   +5 more
core   +3 more sources