Results 81 to 90 of about 29,322 (305)

Std fimbriae-fucose interaction increases Salmonella-induced intestinal inflammation and prolongs colonization [PDF]

, 2019
Author summary The intestinal epithelium is a crucial biological interface, interacting with both commensal and pathogenic microorganisms. It’s lined with heavily glycosylated proteins and glycolipids which can act as both attachment sites and energy ...
Baines, J., Boyle, E., Casadesús, J., Gal-Mor, O., Galeev, A., García Pastor, L., Grassl, G., Hensel, M., Riedel, R., Seeger, K., Sharma, S., Sterzenbach, T., Suwandi, A.   +12 more
core   +1 more source

A 3D Biofabricated Disease Model Mimicking the Brain Extracellular Matrix Suitable to Characterize Intrinsic Neuronal Network Alterations in the Presence of a Breast Tumor Disseminated to the Brain

Advanced Functional Materials, EarlyView.
A 3D disease model is developed using customized hyaluronic‐acid‐based hydrogels supplemented with extracellular matrix (ECM) proteins resembling brain ECM properties. Neurons, astrocytes, and tumor cells are used to mimic the native brain surrounding.
Esra Türker, Mateo S. Andrade Mier, Jessica Faber, Mike Friedrich, Zan Lamberger, Jeannette Weigelt, Christian Stigloher, Nicoletta Murenu, Natascha Schaefer, Jörg Tessmar, Gregor Lang, Silvia Budday, Katrin G. Heinze, Antje Appelt‐Menzel, Pamela L. Strissel, Reiner Strick, Carmen Villmann   +16 more
wiley   +1 more source

Drug discovery via human-derived stem cell organoids

Frontiers in Pharmacology, 2016
Patient-derived cell lines and animal models have proven invaluable for the understanding of human intestinal diseases and for drug development although both inherently comprise disadvantages and caveats.
Fangkun Liu, Fangkun Liu, Jing Huang, Jing Huang, Bo Ning, Zhixiong Liu, Shen Chen, Shen Chen, Wei Zhao, Wei Zhao   +9 more
doaj   +1 more source

Loss of Adenomatous polyposis coli function renders intestinal epithelial cells resistant to the cytokine IL-22 [PDF]

, 2019
Interleukin-22 (IL-22) is a critical immune defence cytokine that maintains intestinal homeostasis and promotes wound healing and tissue regeneration, which can support the growth of colorectal tumours.
A Metidji, AJ Langlands, AJ Rowan, AJ Valvezan, B Ahn, C Wang, CA Lindemans, CD Chung, Connie J. Eaves, D Dikovskaya, E Elinav, EM Giles, G Pickert, H Ahlfors, I Kryczek, Ian P. Newton, Ignacio Moraga, Inke S. Näthke, J Behnsen, J Schindelin, J Zhang, JA Dudakov, JL Stamos, JV Newman, K Aden, K Gronke, K Wang, K Wolk, KW Kinzler, L Icardi, LMP Loonen, M Fischer, Mahima Swamy, Maud Vandereyken, MH Xie, ML Nagalakshmi, NM Weathington, NR West, R Jiang, R Starr, S Brand, S Giraud, S Huber, S Kawanishi, S Kirchberger, S Vaishnava, SI Grivennikov, SL Sanos, SV Kotenko, T Sato, TAN Pham, TL Putoczki, X Xue, Y Li, Y Zheng, Y-H Huang, Yu Chen, Z Wen, Z-l Yuan   +58 more
core   +2 more sources

Study Bacteria–Host Interactions Using Intestinal Organoids [PDF]

, 2016
The intestinal epithelial cells function to gain nutrients, retain water and electrolytes, and form an efficient barrier against foreign microbes and antigens. Researchers employed cell culture lines derived from human or animal cancer cells as experimental models in vitro for understanding of intestinal infections.
Yong-Guo, Zhang, Jun, Sun
openaire   +2 more sources

Expanding Chemical Space of Nucleic Acid Nanoparticles for Tunable Antiviral‐Like Immunomodulatory Responses and Potent Adjuvant Activity

Advanced Functional Materials, EarlyView.
We introduce a nucleic acid nanoparticle (NANP) platform designed to be rrecognized by the human innate immune system in a regulated manner. By changing chemical composition while maintaining constant architectural parameters, we identify key determinants of immunorecognition enabling the rational design of NANPs with tunable immune activation profiles
Martin Panigaj, Hannah S. Newton, Jian Wang, Laxmi Pandey, Yelixza I. Avilla, Phong Nguyen, Morgan Chandler, Justin Halman, Yasmine Radwan, Stephanie Smith, Elijah Edmondson, Simone Difilippantonio, Chelsea Sanders, Bao Tran, Yongmei Zhao, Shaojun Xie, Edward Cedrone, Barry W. Neun, Meni Wanunu, Nikolay V. Dokholyan, Marina A. Dobrovolskaia, Kirill A. Afonin   +21 more
wiley   +1 more source

Rapid, Efficient, and Universally Applicable Genetic Engineering of Intestinal Organoid with a Sequential Monolayer to Three-Dimensional Strategy

Stem Cells International
Genetically modified intestinal organoids are being explored as potential surrogates of immortalized cell lines and gene-engineered animals. However, genetic manipulation of intestinal organoids is time-consuming, and the efficiency is far beyond ...
Weili Han, Guofang Lu, Sheng Zhao, Rui Wang, Haohao Zhang, Kun Liu, Yongzhan Nie, Jiaqiang Dong   +7 more
doaj   +1 more source

Organoids as a model for colorectal cancer [PDF]

, 2016
Modelling human diseases in in vitro systems is undisputedly an invaluable research tool, yet there are many limitations. Some of those limitations have been overcome through the introduction of organoid culture systems, which have revolutionised ...
Reed, Karen Ruth, Young, Madeleine
core   +2 more sources

Generation of an Induced Pluripotent Stem Cell‐Derived Alveolar Type II In Vitro Model to Study Influenza A Virus Infection and Drug Treatments

Advanced Healthcare Materials, EarlyView.
Patient‐specific induced pluripotent stem cells (iPSCs) can be differentiated into alveolar type II cells (iAT2s), expanded as 3D alveolospheres, and grown at physiologically relevant air–liquid interface (ALI). This study shows for the first time the infectability of iAT2s by the influenza A virus (IAV) and proves their responsiveness to the well ...
Lena Gauthier, Hristina Koceva, Yann Bachelot, Rosanne W. Koutstaal, Puck B. van Kasteren, Marc Thilo Figge, Christian Eggeling, Alexander Sandy Mosig   +7 more
wiley   +1 more source

Initial pig developmental stage influences intestinal organoid growth but not cellular composition

Animal Models and Experimental Medicine
Background Intestinal organoids are promising tools in the context of animal experiment reduction but a thorough characterization of the impact of the origin of intestinal stem cells (ISC) on organoid phenotype is needed to routinely use this cellular ...
Camille Duchesne, Gwénaëlle Randuineau, Laurence Le Normand, Véronique Romé, Samia Laraqui, Alexis Pierre Arnaud, Gaëlle Boudry   +6 more
doaj   +1 more source