Progress of Research on Mechanism of Intestinal Nervous System Regulating Intestinal Inflammation Based on Intestinal Stem Cells [PDF]
Zhongguo quanke yixueIntestinal stem cells are regulated by the intestinal nervous system, and both of them are closely related to intestinal inflammation. Relevant studies have shown the existence of intestinal nerve dysfunction in intestinal inflammation.
CHEN Siqi, XIAO Jin, TIAN Siyu, ZHANG Jia, WANG Shuting, ZHANG Xindan, ZHU Yan, CHEN Min
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Ribosome impairment regulates intestinal stem cell identity via ZAKɑ activation
Nature Communications, 2022 Intestinal stem cells are responsible for replenishing cells within the high-turnover intestinal epithelium. Here they show that ribosome dynamics affect intestinal stem cell identity through a mechanism that is triggered by changes in nutrient ...
Joana Silva +14 more
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Paneth Cells and Lgr5+ Intestinal Stem Cells in Radiation Enteritis
Applied Sciences, 2023 Cancer is the leading cause of death in adults and majority of cancers involve abdominal and pelvic organs. Radiotherapy is used in the management of around half of patients who have abdominal and pelvic malignancies and 70% of the treated patients will ...
Thifhelimbilu Luvhengo +2 more
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Biological Research, 2018 Background The WNT pathway regulates intestinal stem cells and is frequently disrupted in intestinal adenomas. The pathway contains several potential biotargets for interference, including the poly-ADP ribosyltransferase enzymes tankyrase1 and 2. LGR5 is
Jens Henrik Norum +6 more
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Research progress on the role of prostaglandin E2 in promoting recovery of intestinal mucosal injury [PDF]
Xin yixue, 2022 Prostaglandin E2 （PGE2）, as a member of prostaglandin E, belongs to eicosanoids. It participates in inflammatory reaction and immune regulation. Under normal physiological conditions, intestinal mucosa undergoes persistent self-renewal.
Yue Mengzhen, Fan Hancheng, Zhu Qingxian, Zeng Huihong, Shao Lijian
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An individual based computational model of intestinal crypt fission and its application to predicting unrestrictive growth of the intestinal epithelium. [PDF]
, 2014 Intestinal crypt fission is a homeostatic phenomenon, observable in healthy adult mucosa, but which also plays a pathological role as the main mode of growth of some intestinal polyps.
A. Patrick Gunning +69 more
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ERBB3 Positively Correlates with Intestinal Stem Cell Markers but Marks a Distinct Non Proliferative Cell Population in Colorectal Cancer. [PDF]
PLoS ONE, 2015 Several studies have suggested ERBB3/HER3 may be a useful prognostic marker for colorectal cancer. Tumours with an intestinal stem cell signature have also been shown to be more aggressive. Here, we investigate whether ERBB3 is associated with intestinal
Thierry Jardé +7 more
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The Current Use of Stem Cells in Bladder Tissue Regeneration and Bioengineering. [PDF]
, 2017 Many pathological processes including neurogenic bladder and malignancy necessitate bladder reconstruction, which is currently performed using intestinal tissue. The use of intestinal tissue, however, subjects patients to metabolic abnormalities, bladder
Chan, Yvonne Y +3 more
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Foxl1-Expressing Mesenchymal Cells Constitute the Intestinal Stem Cell NicheSummary
Cellular and Molecular Gastroenterology and Hepatology, 2016 Background & Aims: Intestinal epithelial stem cells that express leucine-rich repeat-containing G-protein coupled receptor 5 (Lgr5) and/or B cell specific Moloney murine leukemia virus integration site 1 (Bmi1) continuously replicate and generate ...
Reina Aoki +10 more
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Intestinal Stem Cells: Got Calcium? [PDF]
Current Biology, 2016 Calcium ions are well-known intracellular signalling molecules. A new study identifies local cytoplasmic calcium as a central integrator of metabolic and proliferative signals in Drosophila intestinal stem cells.
Naszai, Mate, Cordero, Julia
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