Results 121 to 130 of about 1,797,820 (320)

Interaction between ischemia-reperfusion injury and intestinal microecology in organ transplantation and its therapeutic prospects

Frontiers in Immunology
Organ transplantation is a vital intervention for end-stage organ failure; however, ischemia-reperfusion injury is a complication of transplantation, affecting the prognosis and survival of transplant recipients.
Yong-qi Lian, Peng-fei Li, Yan Guo, Yan-lin Tao, Ya-nan Liu, Zhao-yu Liang, Shu-fen Zhu   +6 more
doaj   +1 more source

Potent Liver‐Tropic mRNA Lipid Nanoparticles: ApoE‐Mediated Delivery Through a Low‐Density Lipoprotein Receptor Independent Uptake Mechanism

Advanced Materials, EarlyView.
Helper and ionizable lipids play a crucial role in determining ApoE binding and subsequent liver tropism and LDLR‐mediated uptake. Ionizable lipids primarily govern the LDLR‐independent uptake pathway. This complementary interplay between lipid components ultimately governs LNP delivery performance and therapeutic efficacy in the liver.
Ashish Sarode, Christian Ortiz, Tadeh Derstepanian, Natalia Vargas‐Montoya, Priyal Patel, Nikita Khadse, Saikat Manna, Ryan Landis, Joseph Skaleski, Lianne Boeglin, Hongfeng Deng, Anusha Dias, Hong Wang, Debora Barreiros Petropolis, Barak Yahalom, Shrirang Karve, Frank DeRosa   +16 more
wiley   +1 more source

Therapeutic faecal microbiota transplantation controls intestinal inflammation through IL10 secretion by immune cells

Nature Communications, 2018
Alteration of the gut microbiota has been associated with different gastrointestinal disorders. Normobiosis restoration by faecal microbiota transplantation (FMT) is considered a promising therapeutic approach, even if the mechanisms underlying its ...
C. Burrello, F. Garavaglia, F. Cribiù, G. Ercoli, G. Lopez, J. Troisi, Angelo Colucci, S. Guglietta, S. Carloni, S. Guglielmetti, Valentina Taverniti, G. Nizzoli, S. Bosari, F. Caprioli, M. Rescigno, F. Facciotti   +15 more
semanticscholar   +1 more source

Anthropometrics, body composition, sarcopenia, and frailty in intestinal transplantation: A literature review and commentary

Intestinal Failure
Frailty and sarcopenia are increasingly incorporated in the evaluation of solid organ transplant candidates. There can be adverse outcomes both pre- and post-transplant amongst patients identified as frail. Nutritional deficiencies and chronic illness in
Faruq Pradhan, Yara Dababneh, Thomas Pietrowsky, Syed-Mohammed Jafri, Shaheed Merani   +4 more
doaj   +1 more source

Serotonergic System‐Targeted Nucleic Acid Hydrogel Coordinates Excitability Restoration and Circuit Reconstruction for Spinal Cord Injury Therapy

Advanced Materials, EarlyView.
The study reports a DNA/RNA heteroduplex hydrogel (SeroPTEN‐CG) that undergoes DNase‐mediated hydrogel‐to‐nanogel transition for spinal cord injury therapy by targeting the serotonergic system, combining 5‐hydroxytryptamine (5‐HT)‐mediated excitability restoration to reactivate dormant interneurons with phosphatase and tensin homolog (PTEN)‐targeted ...
Chunlin Li, Xiaoqing Zhao, Kai Jiang, Haixia Kang, Shuo Liu, Linlin Jiang, Baoshuai Bai, Haonan Cui, Ziyang Zhang, Menglei Dong, Ruizhi Zhang, Chenbo Zou, Shenghui Shang, Chi Zhang, Xiangchuang Fan, Lijuan Zhu, Huiquan Duan, Chuan Zhang, Shiqing Feng, Hengxing Zhou   +19 more
wiley   +1 more source

Piezoelectric Stimulation of Neural Cells: Exploring the Synergistic Potential of Hybrid Scaffolds for Enhanced Regeneration

Advanced Materials Interfaces, EarlyView.
Hybrid piezoelectric scaffolds offer a promising route for Central Nervous System regeneration by combining structural and electrical cues to support neural stem cell growth. This review highlights their potential to overcome current challenges in neural tissue engineering by exploring porous hybrid materials, their biological interactions, and ...
Heather F. Titterton, Chris R. Bowen, Hamideh Khanbareh   +2 more
wiley   +1 more source

Anaesthesia for intestinal transplantation. [PDF]

BJA Educ, 2023
Klucniks A, Kerner V.
europepmc   +1 more source

Development of Artificial Sebaceous Gland‐Integrated In Vitro Human Skin Model

Advanced Materials Interfaces, EarlyView.
Uniform 3D artificial sebaceous gland spheroids, termed SebaSpheres, are generated at high throughput using a microfluidic platform and structurally integrated into a collagen‐based skin construct containing fibroblasts and keratinocytes. This work presents a modular and scalable fabrication and integration strategy for incorporating sebaceous gland ...
Daeun Ryu, Hyewon Noh, Jimin Son, Haejung Lee, Bo Mi Kang, Chong Won Choi, Jong Hwan Sung, Jae Jung Kim   +7 more
wiley   +1 more source

Present state of intestinal transplantation in Japan. [PDF]

Pediatr Surg Int, 2023
Ueno T, Wada M, Ogawa E, Matsuura T, Yamada Y, Sakamoto S, Okuyama H.   +6 more
europepmc   +1 more source

The many faces of multivisceral transplantation [PDF]

, 1991
The transplantation of multiple abdominal viscera, including liver-duodenum-pancreas, liver-stomach-duodenum-pancreas and liver-intestine, is being performed with increasing frequency and success.
Abu-Elmagd, K, Alessiani, M, Casavilla, A, Fung, JJ, Starzl, TE, Todo, S, Tzakis, A   +6 more
core