Results 51 to 60 of about 1,797,820 (320)

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source

Alpha1-antitrypsin protects the intestine from ischemia-reperfusion injury in a rat intestinal clamping model

Intestinal Failure
Background: Ischemia-reperfusion injury (IRI) remains a significant hurdle when blood flow is restored to ischemic tissue. Alpha1-antitrypsin (AAT), a serine protease inhibitor, has demonstrated strong anti-inflammatory properties, including inhibition ...
Antoine Dubois, Mathias Clarysse, Ricard Farré, Tine Wylin, Veerle Heetfeld, Emilio Canovai, Tim Vanuytsel, Gert De Hertogh, Jacques Pirenne, Laurens J. Ceulemans   +9 more
doaj   +1 more source

Is rejection a diffuse or localized process in small-bowel transplantation? [PDF]

, 1994
Utilization of endoscopy to both visualize and selectively biopsy an intestinal allograft has become the standard for early recognition and treatment of intestinal allograft rejection.
A Jain, A. Gurakar, B Banner, CC Inshan Clark, D. H. Van Thiel, E. Frezza, H. I. Wright, K Abu-Elmagd, K Nakamura, K Nakamura, KM Abu-Elmagd, M. Balkan, P Schroeder, S Todo, S Todo, S Todo, S Todo, S. Fagiuoli, S. Todo, T. E. Starzl, T. Hassanein   +20 more
core   +1 more source

Gut microbiota diversity is prognostic in metastatic hormone receptor‐positive breast cancer patients receiving chemotherapy and immunotherapy

Molecular Oncology, EarlyView.
In this exploratory study, we investigated the relationship between the gut microbiota and outcome in patients with metastatic hormone receptor‐positive breast cancer, treated in a randomized clinical trial with chemotherapy alone or chemotherapy in combination with immune checkpoint blockade.
Andreas Ullern, Kristian Holm, Nikolai Kragøe Andresen, Andreas Hagen Røssevold, Corinna Bang, Bjørn Naume, Johannes R. Hov, Jon Amund Kyte   +7 more
wiley   +1 more source

History of intestinal transplantation in Australia

Intestinal Failure
Intestinal transplantation was introduced into Australia in 2010 to meet the need of a small number of patients with irreversible intestinal failure who would otherwise need to travel abroad to access this life-saving therapy.
Katrina Tan, Brooke Chapman, Darren Wong, Jason Yap, Graham Starkey, Adam Testro   +5 more
doaj   +1 more source

Function and expression of cystic fibrosis transmembrane conductance regulator after small intestinal transplantation in mice. [PDF]

PLoS ONE, 2013
The secretion function of intestinal graft is one of the most important factors for successful intestinal transplantation. Cystic fibrosis transmembrane conductance regulator (CFTR) mediates HCO3(-) and Cl(-) secretions in intestinal epithelial cells. In
Penghong Song, Wenfeng Song, Xiaosun Liu, Changhai Jin, Haiyang Xie, Lin Zhou, Biguang Tuo, Shusen Zheng   +7 more
doaj   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Fecal Microbiota Transplantation Prevents Intestinal Injury, Upregulation of Toll-Like Receptors, and 5-Fluorouracil/Oxaliplatin-Induced Toxicity in Colorectal Cancer

International Journal of Molecular Sciences, 2020
FOLFOX (5-fluorouracil, leucovorin, and oxaliplatin), a 5-fluorouracil (5-FU)-based chemotherapy regimen, is one of most common therapeutic regimens for colorectal cancer.
Ching‐Wei Chang, Hung-Chang Lee, Li-hui Li, Jen-Shiu Chiang Chiau, Tsang-En Wang, W. Chuang, Ming‐Jen Chen, Horng‐Yuan Wang, S. Shih, chia-Yuan liu, T. Tsai, Yu-Jen Chen   +11 more
semanticscholar   +1 more source

Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA

Molecular Oncology, EarlyView.
Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson, Anders Lade Nielsen, Boe Sandahl Sorensen   +2 more
wiley   +1 more source

Assessment of liver stiffness and steatosis in patients with intestinal failure: a cross-sectional study

Frontiers in Nutrition
IntroductionIntestinal failure-associated liver disease is a potentially life-threatening complication in patients with intestinal failure (IF) receiving home parenteral support (HPS).
Ena Muhic, Rahim Mohammad Naimi, Christopher Filtenborg Brandt, Thomas Lund Andersen, Thomas Lund Andersen, Helle Hjorth Johannesen, Palle Bekker Jeppesen   +6 more
doaj   +1 more source