Results 21 to 30 of about 1,373,251 (190)

Cellular immune responses in amniotic fluid of women with preterm labor and intra-amniotic infection or intra-amniotic inflammation. [PDF]

Am J Reprod Immunol, 2019
AbstractProblemPreterm birth is commonly preceded by preterm labor, a syndrome that is causally linked to both intra‐amniotic infection and intra‐amniotic inflammation. However, the stereotypical cellular immune responses in these two clinical conditions are poorly understood.Method of studyAmniotic fluid samples (n = 26) were collected from women ...
Gomez-Lopez N, Romero R, Galaz J, Xu Y, Panaitescu B, Slutsky R, Motomura K, Gill N, Para R, Pacora P, Jung E, Hsu CD.   +11 more
europepmc   +5 more sources

Inflammasome activation during spontaneous preterm labor with intra-amniotic infection or sterile intra-amniotic inflammation. [PDF]

Am J Reprod Immunol, 2018
ProblemThe inflammasome is implicated in the mechanisms that lead to spontaneous preterm labor (PTL). However, whether there is inflammasome activation in the amniotic cavity of women with PTL and intra‐amniotic infection (IAI) or sterile intra‐amniotic inflammation (SIAI) is unknown.Method of studyAmniotic fluid samples were collected from women with ...
Gomez-Lopez N, Romero R, Panaitescu B, Leng Y, Xu Y, Tarca AL, Faro J, Pacora P, Hassan SS, Hsu CD.   +9 more
europepmc   +5 more sources

Gasdermin D: Evidence of pyroptosis in spontaneous preterm labor with sterile intra-amniotic inflammation or intra-amniotic infection. [PDF]

Am J Reprod Immunol, 2019
AbstractProblemPyroptosis, inflammatory programmed cell death, is initiated through the inflammasome and relies on the pore‐forming actions of the effector molecule gasdermin D. Herein, we investigated whether gasdermin D is detectable in women with spontaneous preterm labor and sterile intra‐amniotic inflammation or intra‐amniotic infection.Method of ...
Gomez-Lopez N, Romero R, Tarca AL, Miller D, Panaitescu B, Schwenkel G, Gudicha DW, Hassan SS, Pacora P, Jung E, Hsu CD.   +10 more
europepmc   +5 more sources

Characterization of vaginal microbiota in women with preterm labor with intra-amniotic inflammation. [PDF]

Sci Rep, 2019
AbstractThis study aims to investigate the relation between vaginal microbiota and exposition to intra-amniotic inflammation (IAI). We conducted a prospective cohort study in women with preterm labor <34 weeks who had undergone amniocentesis to rule out IAI. Vaginal samples were collected after amniocentesis.
Cobo T, Vergara A, Collado MC, Casals-Pascual C, Herreros E, Bosch J, Sánchez-García AB, López-Parellada R, Ponce J, Gratacós E.   +9 more
europepmc   +8 more sources

The immunobiology of preterm labor and birth: intra-amniotic inflammation or breakdown of maternal-fetal homeostasis. [PDF]

Reproduction, 2022
In brief: The syndrome of preterm labor comprises multiple established and novel etiologies. This review summarizes the distinct immune mechanisms implicated in preterm labor and birth and highlights potential strategies for its prevention.
Gomez-Lopez N, Galaz J, Miller D, Farias-Jofre M, Liu Z, Arenas-Hernandez M, Garcia-Flores V, Shaffer Z, Greenberg JM, Theis KR, Romero R.   +10 more
europepmc   +2 more sources

Intra-amniotic inflammation induces preterm birth by activating the NLRP3 inflammasome†. [PDF]

Biol Reprod, 2019
Abstract Intra-amniotic inflammation is strongly associated with spontaneous preterm labor and birth, the leading cause of perinatal mortality and morbidity worldwide. Previous studies have suggested a role for the NLRP3 (NLR family pyrin domain-containing protein 3) inflammasome in the mechanisms that lead to preterm labor and birth.
Faro J, Romero R, Schwenkel G, Garcia-Flores V, Arenas-Hernandez M, Leng Y, Xu Y, Miller D, Hassan SS, Gomez-Lopez N.   +9 more
europepmc   +4 more sources

External validation of a non-invasive vaginal tool to assess the risk of intra-amniotic inflammation in pregnant women with preterm labor and intact membranes [PDF]

Journal of Perinatal Medicine
To prospectively validate the diagnostic performance of a non-invasive point-of-care tool (Rapid IAI System), including vaginal alpha-fetoprotein and interleukin-6, to predict the occurrence of intra-amniotic inflammation in a Spanish cohort of patients ...
Cobo Teresa, Burgos-Artizzu Xavier P., Ferrero Silvia, Balcells Judith, Bosch Jordi, Gené Amadeu, Murillo Clara, Rueda Claudia, Boada David, Sánchez-Antón Maria Teresa, Kacerovsky Marian, Jacobsson Bo, Palacio Montse   +12 more
doaj   +2 more sources

The Frequency and Clinical Significance of Intra-Amniotic Inflammation in Twin Pregnancies With Preterm Labor and Intact Membranes [PDF]

Journal of Maternal-Fetal and Neonatal Medicine, 2019
Joon-Seok Hong, Roberto Romero, Kyung Joon Oh   +2 more
exaly   +2 more sources

Prevalence and Load of Cervical Ureaplasma Species With Respect to Intra-amniotic Complications in Women With Preterm Prelabor Rupture of Membranes Before 34 weeks

Frontiers in Pharmacology, 2022
Objectives: To determine the prevalence and load of Ureaplasma spp. DNA in the cervical fluid of women with singleton pregnancies complicated by preterm prelabor rupture of membranes (PPROM) with respect to intra-amniotic infection, sterile intra ...
Marian Kacerovsky, Marian Kacerovsky, Rudolf Kukla, Radka Bolehovska, Pavel Bostik, Jana Matulova, Jan Mls, Jaroslav Stranik, Bo Jacobsson, Bo Jacobsson, Bo Jacobsson, Ivana Musilova   +11 more
doaj   +1 more source

Acute chorioamnionitis and intra-amniotic inflammation are more severe according to outside-in neutrophil migration within the same chorio-decidua

Taiwanese Journal of Obstetrics & Gynecology, 2021
Objective: No information exists about whether acute histologic chorioamnionitis (acute-HCA) is more advanced and severe, and intra-amniotic inflammation is more frequent and intense according to outside in neutrophil migration within the same chorio ...
Jeong-Won Oh, Kyung Chul Moon, Chan-Wook Park, Joong Shin Park, Jong Kwan Jun   +4 more
doaj   +1 more source