Results 131 to 140 of about 2,992,178 (408)
Molecular Oncology, EarlyView.We quantified and cultured circulating tumor cells (CTCs) of 62 patients with various cancer types and generated CTC‐derived tumoroid models from two salivary gland cancer patients. Cellular liquid biopsy‐derived information enabled molecular genetic assessment of systemic disease heterogeneity and functional testing for therapy selection in both ...
Nataša Stojanović Gužvić +31 more
wiley +1 more source
RAF inhibitors promote RAS-RAF interaction by allosterically disrupting RAF autoinhibition
Nature Communications, 2017 RAF family kinases transmit signals from activated RAS at the plasma membrane to downstream kinases to control cell proliferation, differentiation and survival. Here the authors shed light on the molecular mechanisms whereby small molecule RAF inhibitors
Ting Jin +6 more
doaj +1 more source
Molecular Oncology, EarlyView.The authors analyzed the spatial distributions of gene and metabolite profiles in cervical cancer through spatial transcriptomic and spatially resolved metabolomic techniques. Pivotal genes and metabolites within these cases were then identified and validated.
Lixiu Xu +3 more
wiley +1 more source
Журнал микробиологии, эпидемиологии и иммунобиологии, 2015 Aim. Comparative phenotypical and genetical evaluation ofpathogenic potential of Staphylococcus aureus strains, isolated from resident bacterial carriers, residing on the territories with anthropogenic pollution of air environment of varying intensity ...
T. M Utkina +4 more
doaj
Frontiers in Microbiology, 2015 Listeria monocytogenes is a bacterial pathogen and causative agent for the foodborne infection listeriosis, which is mainly a threat for pregnant, elderly or immunocompromised individuals. Due to its ability to invade and colonize diverse eukaryotic cell
Tilman Gunter Schultze +10 more
doaj +1 more source
Linear noise approximation for stochastic oscillations of intracellular calcium [PDF]
arXiv, 2013 A stochastic model of intracellular calcium oscillations is analytically studied. The governing master equation is expanded under the linear noise approximation and a closed prediction for the power spectrum of fluctuations analytically derived.
arxiv
Molecular Oncology, EarlyView.This study explores how sepsis affects GC progression by creating an immunosuppressive environment. Our findings reveal that sepsis promotes immune dysregulation, enhancing tumor growth and metastasis. Targeting the PD‐1/PD‐L1 pathway with monoclonal antibodies shows potential for restoring immune function and improving outcomes in cancer patients ...
Yiding Wang +10 more
wiley +1 more source
Modelling intracellular signalling networks using behaviour-based systems and the blackboard architecture [PDF]
arXiv, 2002 This paper proposes to model the intracellular signalling networks using a fusion of behaviour-based systems and the blackboard architecture. In virtue of this fusion, the model developed by us, which has been named Cellulat, allows to take account two essential aspects of the intracellular signalling networks: (1) the cognitive capabilities of certain
arxiv
Molecular Oncology, EarlyView.VASP was found to be overexpressed in metastatic oral squamous cell carcinoma (OSCC) tissues. Notably, PTTG1‐ and VASP‐deficient OSCC cells demonstrated suppressed metastatic properties by disrupting the interaction between the cytoskeleton and focal adhesion (FAs) in the filopodia region.
Suyeon Park +6 more
wiley +1 more source
Frontiers in Neural Circuits, 2011 Animals typically perceive natural odor cues in their olfactory environment as a complex mixture of chemically diverse components. In insects, the initial representation of an odor mixture occurs in the first olfactory center of the brain, the antennal ...
Linda S Kuebler +3 more
doaj +1 more source