Results 51 to 60 of about 2,142,587 (349)
Molecular bases of circadian magnesium rhythms across eukaryotes
FEBS Letters, EarlyView.Circadian rhythms in intracellular [Mg2+] exist across eukaryotic kingdoms. Central roles for Mg2+ in metabolism suggest that Mg2+ rhythms could regulate daily cellular energy and metabolism. In this Perspective paper, we propose that ancestral prokaryotic transport proteins could be responsible for mediating Mg2+ rhythms and posit a feedback model ...
Helen K. Feord, Gerben van Ooijen
wiley +1 more source
Frontiers in Oncology, 2022 T cells play a key role in anticancer immunity, with responses mediated through a diversity of αβ or γδ T cell receptors. Although αβ and γδ T cells stem from common thymic precursors, the development and subsequent biological roles of these two subsets ...
Anne B. C. Cherry +2 more
doaj +1 more source
Combination Cancer Treatment: Using Engineered DNAzyme Molecular Machines for Dynamic Inter‐ and Intracellular Regulation [PDF]
, 2022 Ruo‐Can Qian +6 more
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Intracellular Metal Detectors [PDF]
ACS Chemical Biology, 2006 Metal ions play numerous crucial roles in biology, and there is great interest in obtaining an accurate measurement of the intracellular concentrations of both tightly bound and exchangeable metal ions. Measuring the concentration of readily exchangeable transition metal ions in a cell has been particularly difficult because of the extremely small ...
openaire +2 more sources
Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer
FEBS Letters, EarlyView.Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani +4 more
wiley +1 more source
Parasites & Vectors, 2015 Background With the exception of Bartonella spp. or Cytauxzoon felis, feline vector-borne pathogens (FVBP) have been less frequently studied in North America and are generally under-appreciated as a clinical entity in cats, as compared to dogs or people.
Barbara C. Hegarty +7 more
doaj +1 more source
Targeting intracellular oncoproteins with dimeric IgA promotes expulsion from the cytoplasm and immune-mediated control of epithelial cancers [PDF]
, 2023 Subir Biswas +21 more
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Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
Function‐driven design of a surrogate interleukin‐2 receptor ligand
FEBS Letters, EarlyView.Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang +9 more
wiley +1 more source
Журнал микробиологии, эпидемиологии и иммунобиологии, 2015 Aim. Evaluate immune regulatory properties ofbifidobacteria metabolites during eubiosis and dysbiosis of the human colon. Materials and methods. Anti-cytokine activity of metabolites of bifidobacteria clinical strains and their ability to influence the ...
O. V. Bukharin +5 more
doaj