Results 31 to 40 of about 758,848 (328)

Viruses and Lipids

Viruses, 2010
As obligatory intracellular pathogens, viruses exploit various cellular molecules and structures, such as cellular membranes, for their propagation.
Akira Ono
doaj   +1 more source

Intracellular Membrane Traffic at High Resolution [PDF]

, 2010
Membrane traffic between organelles is essential for a multitude of processes that maintain cell homeostasis. Many steps in these tightly regulated trafficking pathways take place in microdomains on the membranes of organelles, which require analysis at nanometer resolution. Electron microscopy (EM) can visualize these processes in detail and is mainly
van Weering, JRT, Brown, E, Sharp, TH, Mantell, J, Cullen, PJ, Verkade, P   +5 more
openaire   +4 more sources

Cholesterol impairment contributes to neuroserpin aggregation [PDF]

, 2017
Intraneural accumulation of misfolded proteins is a common feature of several neurodegenerative pathologies including Alzheimer's and Parkinson's diseases, and Familial Encephalopathy with Neuroserpin Inclusion Bodies (FENIB). FENIB is a rare disease due
Costantini, Giulio, Giampietro, Costanza, La Porta, Caterina A. M., Lionetti, Maria Chiara, Mutti, Federico, Zapperi, Stefano   +5 more
core   +2 more sources

A bacteriophage endolysin that eliminates intracellular streptococci

eLife, 2016
PlyC, a bacteriophage-encoded endolysin, lyses Streptococcus pyogenes (Spy) on contact. Here, we demonstrate that PlyC is a potent agent for controlling intracellular Spy that often underlies refractory infections.
Yang Shen, Marilia Barros, Tarek Vennemann, D Travis Gallagher, Yizhou Yin, Sara B Linden, Ryan D Heselpoth, Dennis J Spencer, David M Donovan, John Moult, Vincent A Fischetti, Frank Heinrich, Mathias Lösche, Daniel C Nelson   +13 more
doaj   +1 more source

Contacting domains segregate a lipid transporter from a solute transporter in the malarial host–parasite interface

Nature Communications, 2020
While membrane contact sites between intracellular organelles are abundant, little is known about the contacts between membranes that delimit extracellular junctions within cells, such as intracellular parasites.
Matthias Garten, Josh R. Beck, Robyn Roth, Tatyana Tenkova-Heuser, John Heuser, Eva S. Istvan, Christopher K. E. Bleck, Daniel E. Goldberg, Joshua Zimmerberg   +8 more
doaj   +1 more source

Lipid Phosphate Phosphatases and Cancer

Biomolecules, 2020
Lipid phosphate phosphatases (LPPs) are a group of three enzymes (LPP1–3) that belong to a phospholipid phosphatase (PLPP) family. The LPPs dephosphorylate a wide spectrum of bioactive lipid phosphates, among which lysophosphatidate (LPA) and sphingosine
Xiaoyun Tang, David N. Brindley
doaj   +1 more source

The Inositol- 1,4,5=Trisphosphate System Is Involved in Rapid Effects of Aldosterone in Human Mononuclear Leukocytes [PDF]

, 1993
There is increasing evidence for rapid steroid action on electrolyte transport in human mononuclear leukocytes (HML). In HML, aldosterone stimulates the Na+/H+ antiporter within a few minutes. Because a variety of hormones and growth factors activate the
Aktas, Janet, Christ, Michael, Eisen, Christoph, Theisen, Karl, Wehling, Martin   +4 more
core   +1 more source

Evaluation of Reference Gene Stability for Investigations of Intracellular Signalling in Human Cancer and Non-Malignant Mesenchymal Stromal Cells

Frontiers in Bioscience-Scholar
Background: Real-time reverse transcription quantitative polymerase chain reaction (RT-qPCR) is a powerful tool for analysing target gene expression in biological samples.
Vera Kosheverova, Alexander Schwarz, Rimma Kamentseva, Marianna Kharchenko, Elena Kornilova   +4 more
doaj   +1 more source

High‐Efficient and Dosage‐Controllable Intracellular Cargo Delivery through Electrochemical Metal–Organic Hybrid Nanogates

Small Science, 2021
Hollow nanostructures combined with electroporation are potentially valuable in interdisciplinary fields due to their ability to transport versatile cargos into adhesive cells.
Bowen Zhang, Dinuo Zheng, Shi Yiming, Kazuhiro Oyama, Masahiro Ito, Masaomi Ikari, Takanori Kigawa, Tsutomu Mikawa, Takeo Miyake   +8 more
doaj   +1 more source

Three-dimensional architecture and biogenesis of membrane structures associated with hepatitis C virus replication [PDF]

, 2012
All positive strand RNA viruses are known to replicate their genomes in close association with intracellular membranes. In case of the hepatitis C virus (HCV), a member of the family Flaviviridae, infected cells contain accumulations of vesicles forming ...
Antony, Claude, Bartenschlager, Ralf, Chiramel, Abhilash, Chlanda, Petr, Habermann, Anja, Haselman, Uta, Hoppe, Simone, Kallis, Stephanie, Krijnse-Locker, Jacomine, Lee, Ji-Young, Merz, Andreas, Romero-Brey, Inés, Santarella-Mellwig, Rachel, Walther, Paul   +13 more
core   +3 more sources