Results 201 to 210 of about 281,844 (353)

NK Cell-Mediated Regulation of Protective Memory Responses against Intracellular Ehrlichial Pathogens

, 2016
Samar Habib, Abdeljabar El Andaloussi, A. Abbas Hisham, Nahed Ismail   +3 more
openalex   +2 more sources

Revealing Surface And Intracellular Membrane Morphologies of Host Pathogen Interactions Combining Chromatic Aberration Corrected SEM And STEM Imaging [PDF]

, 2010
Jens Greiser, Ingo Gestmann, Márcia Attias, TC Paredes-Santos   +3 more
openalex   +1 more source

Investigation of IFNγ-induced Control of Intracellular Pathogens

, 2021
Michael R. McAllaster
openalex   +2 more sources

A Bifunctional T3SS‐Effector Simultaneously Cleaves Host MAP Kinase and Inhibits PPM1A Phosphatase

Advanced Science, EarlyView.
Pathogenic bacteria exploit the metalloprotease effector NleD to subvert host defenses. Structural, biochemical, and infection analyses reveal a bifunctional mechanism by which NleD binds and inhibits the host phosphatase PPM1A while preserving its proteolytic activity against MAPKs.
Yaakov Socol, Lihi Gur‐Arie, Netanel Tzarum, Tamara Wellins, Naama Katsowich, Miriam Ravins, Michal Bejerano‐Sagie, Klil Cohen, Oded Livnah, Joshua N. Adkins, Ernesto Nakayasu, Alexei Savchenko, Yeu Khai Choong, Nikhil Kumar Tulsian, Saturo Machida, Sigal Ben‐Yehuda, Yael Litvak, J. Sivaraman, Ilan Rosenshine   +18 more
wiley   +1 more source

How did we get here? Insights into mechanisms of immunity-related GTPase targeting to intracellular pathogens

, 2022
Jacob Dockterman, Jörn Coers
openalex   +2 more sources

Cytolysins from intracellular pathogens

Trends in Microbiology, 1994
N W, Andrews, D A, Portnoy
openaire   +2 more sources

Targeting UXS1‐Dependent Glucuronate Detoxification Potentiates Metformin's Anti‐Tumor Efficacy in Lung Adenocarcinoma

Advanced Science, EarlyView.
This study reveals that metformin promotes glucuronic acid metabolism in lung adenocarcinoma by activating UGDH S476 phosphorylation and enhancing the conversion of UDPG to UDPGA based on metabolomics analysis. Through compound virtual screening, it is found that plantainoside targeting UGDH downstream UXS1 leads to UDPGA toxicity accumulation ...
Qihai Sui, Zhencong Chen, Guangyao Shan, Zhengyang Hu, Xing Jin, Jiaqi Liang, Yanjun Yi, Jiacheng Yin, Haochun Shi, Xifei Jiang, Junjie Xi, Zongwu Lin, Cheng Zhan, Fenghao Sun, Wei Jiang   +14 more
wiley   +1 more source

Insights into the mechanism regulating the differential expression of the P28-OMP outer membrane proteins in obligatory intracellular pathogen Ehrlichia chaffeensis. [PDF]

Emerg Microbes Infect, 2021
Duan N, Ma X, Cui H, Wang Z, Chai Z, Yan J, Li X, Feng Y, Cao Y, Jin Y, Bai F, Wu W, Rikihisa Y, Cheng Z.   +13 more
europepmc   +1 more source

CDK4/6 Inhibition Induces CD8+ T Cell Antitumor Immunity via MIF‐Induced Functional Orchestration of Tumor‐Associated Macrophages

Advanced Science, EarlyView.
CDK4/6 inhibition promotes CD8+ T cell expansion through tumor‐macrophage crosstalk by activating HIF‐1α and enhancing MIF‐CD44/CD74 signaling. This reprograms TAMs to boost MHC‐I antigen presentation, and CDK4/6 inhibitor‐trained M1 TAM supernatant therapy synergizes with low‐dose PD‐1 blockade to restore antitumor immunity.
Lin He, Yuzhong Peng, Lat‐lun Leong, Jingbo Zhou, Dongyang Tang, Weilu Wang, Xiaoran Wu, Josh haipeng Lei, Yongqin Ye, Yangyang Feng, Yunfeng Qiao, Xiangpeng Chu, Di Mu, Qi Zhao, Tzuming Liu, Yan Chen, Paul Kwonghang Tam, Chu‐Xia Deng   +17 more
wiley   +1 more source

Exit of the intracellular pathogen Nematocida parisii from host Caenorhabditis elegans intestinal cells [PDF]

, 2015
A crucial stage in the transmission of diseases that are caused by intracellular pathogens is the exit of these pathogens from their replicative host cell niche.
Szumowski, Suzannah Clark
core