Results 231 to 240 of about 281,844 (353)

Mitochondria protect against an intracellular pathogen by restricting access to folate. [PDF]

Science
Medeiros TC, Ovciarikova J, Li X, Krueger P, Bartsch T, Reato S, Crow JC, Tellez Sutterlin M, Martins Garcia B, Rais I, Allmeroth K, Hartman MD, Denzel MS, Purrio M, Mesaros A, Leung KY, Greene NDE, Sheiner L, Giavalisco P, Pernas L.   +19 more
europepmc   +1 more source

PRMT1‐Mediated LDHA Methylation Drives STAT3 Lactylation to Orchestrate Intestinal Inflammation and Tumorigenesis

Advanced Science, EarlyView.
This study identifies an immunometabolic axis wherein SAM‐driven PRMT1 methylates LDHA, enhancing its activity. The resultant lactate induces STAT3 K709 lactylation, which stabilizes an active conformation to promote STAT3 phosphorylation and IL‐10 expression.
Hui Wang, Mengyu Zhang, Weipeng Gong, Jiaxuan Wu, Junping Zhang, Wenxiu Zhang, Yue Liu, Kui Wang, Canhua Huang, Jun Zhou, Sijin Wu, Yan Li, Tianliang Li   +12 more
wiley   +1 more source

The chromatin remodeler LET-418/Mi-2 regulates the intracellular pathogen response in the C. elegans intestine. [PDF]

BMC Genomics
Rajopadhye S, Lažetić V, Rodriguez-Crespo D, Troemel E, Meister P, Wicky C.   +5 more
europepmc   +1 more source

Pp6-Pfkfb1 axis modulates intracellular bacterial proliferation by orchestrating host-pathogen metabolic crosstalk

Fan Li, Yang Sun, Fangzhou Lou, Zilong Fang, Wen Ding, Xiangxiao Li, Yan Li, Qing Shen, Siyu Deng, Jihuan Liang, Fengjiao Zhang, Sibei Tang, Zhikai Wang, Xiaojie Cai, Jiajia Tong, Zhenyao Xu, Jing Zou, Qin Yang, Honglin Wang   +18 more
openalex   +1 more source

Human blood monocytes support persistence, but not replication of the intracellular pathogen C. pneumoniae [PDF]

, 2014
Tanja Buchacher, Herbert Wiesinger-Mayr, Klemens Vierlinger, Beate M. Rüger, Gerold Stanek, Michael B. Fischer, Viktoria Weber   +6 more
openalex   +1 more source

RNA Helicase DDX21 Controls CD4+ T Cell Proliferation and Promotes Inflammatory Bowel Disease via Translational Control

Advanced Science, EarlyView.
ABSTRACT Inflammatory bowel disease (IBD) is characterized by dysregulated T cell responses. RNA helicases, including DExD‐box helicase 21 (DDX21), are pivotal in RNA metabolism, but their role in T cell‐mediated pathology during IBD remains unclear. Here, we demonstrate that DDX21 expression in CD4+ T cells correlates with cell cycle and translation ...
Yujuan Zhang, Chen Kan, Xinhui Yang, Yajuan Hao, Xuemin Cai, Mei Yang, Qianqian Zhang, Zhengting Wang, Ning Jiang, Lei Wang, Hua‐Bing Li, Jing Zhou   +11 more
wiley   +1 more source

Intracellular pathogen effector reprograms host gene expression by inhibiting mRNA decay. [PDF]

Nat Commun
Levdansky Y, Deme JC, Turner DJ, Piczak CT, Pekovic F, Valkov AL, Tarasov SG, Lea SM, Valkov E.   +8 more
europepmc   +1 more source

Exposure to stressors and antimicrobials induces cell-autonomous ultrastructural heterogeneity of an intracellular bacterial pathogen [PDF]

, 2020
Marc Schulte, Michael Hensel, Katarzyna Miśkiewicz   +2 more
openalex   +1 more source

Enhanced Glycolysis‐Driven Histone H3K18 Lactylation Regulates Epileptogenesis by Modulating the E3 Ubiquitin Ligase COP1

Advanced Science, EarlyView.
Neuronal PKM2‐driven glycolysis generates excess lactate that triggers histone H3K18 lactylation (H3K18la), establishing a pathogenic metabolic‐epigenetic axis in epilepsy. Elevated H3K18la enriches the Cop1 promoter, transcriptionally upregulating the E3 ubiquitin ligase COP1, which subsequently drives proteasomal degradation of GABAARβ2 and impairs ...
Yuan Meng, Yanlin Guo, Liumi Jiang, Jing Luo, Yan Liu, Ziwei Yuan, Pingyang Ke, Ran Duan, Fei Xiao   +8 more
wiley   +1 more source

A natural killer cell mimic against intracellular pathogen infections. [PDF]

Sci Adv
Ge M, Ruan Z, Zhu YX, Wu W, Yang C, Lin H, Shi J.   +6 more
europepmc   +1 more source