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Vaccines against Intracellular Pathogens
2000Vaccination against intracellular pathogens presents unique problems that are specific to the growth environment used by these organisms. For all vaccines it is important to determine the best antigen(s) and inoculation method that will induce the proper strength and type of immune response as well as protect against subsequent challenge.
R G, Barletta +4 more
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Targeted therapy for intracellular pathogens
Trends in Parasitology, 2001Exploitation of CD40 ligand (CD40L) has been proposed as a novel vaccine strategy to combat intracellular pathogens. G. Chen et al. (2001) (Infect. Immun. 69, 3255–3263) report that injecting a combination of CD40L and Leishmania-derived antigen into mice is an effective way to preferentially induce type 1 (cell-mediated) immune responses to the ...
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Immunogenetics in the analysis of resistance to intracellular pathogens
Current Opinion in Immunology, 1995Recent studies have identified genes involved in resistance to intracellular pathogens. Such genes include the murine MHC class I gene, Ld (toxoplasmosis), HLA-BW53, HLA DRB1* 1302-DQ B10s01 and TNF2 (malaria), murine Nramp (toxoplasmosis, leishmaniasis and tuberculosis), gene(s) modulating the T-helper type 1 and type 2 dichotomy (leishmaniasis ...
R, McLeod +3 more
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Cytoplasmic access by intracellular bacterial pathogens
Trends in Microbiology, 2014Entry into host cells is a strategy widely used by bacterial pathogens, after which they either remain within membrane-bound compartments or rupture the endocytic vacuole to reach the cytoplasm. During recent years, cytoplasmic access has been documented for an increasing number of pathogens. Here we review how classical cytoplasmic bacterial pathogens
Jennifer Fredlund, Jost Enninga
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Genetic regulation of resistance to intracellular pathogens
Nature, 1982Natural resistance of mice to infections with Salmonella typhimurium and Leishmania donovani is regulated by chromosome 1 gene(s) designated Ity and Lsh, respectively1,2. Given the fact that these two microorganisms are taxonomically and antigenically distinct, and yet the host response to them is regulated by the same locus or complex3,4, one might ...
Skamene, E +5 more
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Mitochondria as sensors of intracellular pathogens
Trends in Endocrinology & MetabolismMitochondria must sense their environment to enable cells and organisms to adapt to diverse environments and survive during stress. However, during microbial infection, an evolutionary pressure since the inception of the eukaryotic cell, these organelles are traditionally viewed as targets for microbes.
Delgado, Jose M., Pernas, Lena
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PATHOGENICITY OF MYCOBACTERIUM INTRACELLULARE TO PIGS
Australian Veterinary Journal, 1971SummaryThe pathologic response of pigs to a strain of M. intracellulare serotype VI was investigated in three trials. Ten mg wet weight of the second subculture maintained on Löwenstein‐Jensen slopes produced a large number of tubercular nodules in the mesenteric lymph node of one pig infected orally, and similar lesions in the iliac lymph nodes of ...
L, Tammemagi, G C, Simmons
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Probing the microenvironment of intracellular bacterial pathogens
Microbes and Infection, 1999The identification of bacterial genes regulated in response to the intracellular environment is crucial to the understanding of host-pathogen interactions. Several techniques have been developed to identify and characterize bacterial genes that are induced during the intracellular infection and, potentially, may play a role in pathogenesis. This review
O S, Harb, Y, Abu Kwaik
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The Challenge of Intracellular Pathogens
New England Journal of Medicine, 1992THE survival of intracellular pathogens in the host depends on their ability to avoid being killed before or after they invade mononuclear phagocytes; these cells are critical in this respect.
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Protective immunity towards intracellular pathogens
Current Opinion in Immunology, 2006Immunity towards intracellular pathogens is often dependent upon the generation of CD8(+) memory T cells, which provide long-lasting and effective protection. Over the past few years, we have gained novel insights into the heterogeneity of CD8(+) T cells, time points of lineage commitment, and lineage relationships between subpopulations. These studies
Katharina M, Huster +2 more
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