Results 271 to 280 of about 281,844 (353)

Pyroptotic cell death defends against intracellular pathogens

, 2020
Edward A. Miao, Ine Jørgensen
openalex   +1 more source

Ultrasound‐Actuated Gene Editing in Human Kidney Organoids

Advanced Science, EarlyView.
Peptide‐stabilized nanoemulsions enable spatially controlled, ultrasound‐triggered delivery of gene‐editing proteins deep within human kidney organoid tissues. Focused acoustic pulses drive droplet vaporization, propelling cargo into target renal cells while preserving native tissue microarchitecture. This non‐viral platform improves both the depth and
Michael A. Miller, Nicole Vo, Utkarsh, Ivan Sokirniy, Justin Pritchard, Benjamin S. Freedman, Scott H. Medina   +6 more
wiley   +1 more source

A Keratinocyte‐Mast Cell NF‐κB2/CXCL2/IL‐6 Amplification Loop Enhances Cutaneous Antifungal Defense Against C. albicans

Advanced Science, EarlyView.
ABSTRACT Mast cells (MCs), key innate immune sentinels at the host–environment interface, serve as primary responders to invading pathogens. However, their specific contribution to host defense against cutaneous Candida albicans (C. albicans) infection and their synergy with other immune and non‐immune cells remain poorly understood. Here, we show that
Yan Yuan, Manyun Mao, Jiaan Zhang, Zhimin Duan, JiaNing Wang, Yujie Chen, Sihan Chen, Chuting Liang, Xvyue Zhou, Songmei Geng, Min Li, Xu Chen, Ni Lian   +12 more
wiley   +1 more source

Subversion of RAB5-regulated autophagy by the intracellular pathogen Ehrlichia chaffeensis. [PDF]

Small GTPases, 2019
Rikihisa Y.
europepmc   +1 more source

Macrophage Extracellular Traps in Immunity and Cancer

Advanced Science, EarlyView.
As a macrophage‐mediated innate defense mechanism, the dysregulated release of METs drives chronic inflammation and influences tumor progression. Furthermore, METs exhibit a functional duality within the tumor microenvironment, capable of both promoting and suppressing tumor development.
Junyao Li, Eugenie Nepovimova, Adam Grundel, Lukas Peter, Qinghua Wu, Kamil Kuca   +5 more
wiley   +1 more source

Role of a fluid-phase PRR in fighting an intracellular pathogen: PTX3 in Shigella infection. [PDF]

PLoS Pathog, 2018
Ciancarella V, Lembo-Fazio L, Paciello I, Bruno AK, Jaillon S, Berardi S, Barbagallo M, Meron-Sudai S, Cohen D, Molinaro A, Rossi G, Garlanda C, Bernardini ML.   +12 more
europepmc   +1 more source

Intracellular Persisting Staphylococcus aureus Is the Major Pathogen in Recurrent Tonsillitis

, 2010
Andreas E. Zautner, Merit Krause, G. Stropahl, Silva Holtfreter, Hagen Frickmann, Claudia Maletzki, Bernd Kreikemeyer, H. Pau, Andreas Podbielski   +8 more
openalex   +2 more sources

Disruption of Treg Homeostasis in Rheumatoid Arthritis via Ferroptosis‐Mediated ETC Collapse and TXK‐STAT3/PLCγ1 Activation

Advanced Science, EarlyView.
In rheumatoid arthritis, synovial Tregs accumulate but are functionally impaired due to iron overload‐induced ferroptosis. This triggers mitochondrial dysfunction and TXK tyrosine kinase‐mediated signaling, leading to Treg destabilization and inflammation.
Jingrong Chen, Xiao Guan, Kexu Xiong, Xiaoyi Shi, Luyao Wu, Chuanxin Su, Jun Zhao, Rongzhen Liang, Huimin Wang, Junlong Dang, Ye Chen, Yiding Xiong, Chi Zhou, Futao Zhao, Zhenhang Zhu, Xiaoli Fan, Li Zhou, Nancy Olsen, Yutong Jiang, Song Guo Zheng   +19 more
wiley   +1 more source

A Metabolic Dependency for Host Isoprenoids in the Obligate Intracellular Pathogen Rickettsia parkeri Underlies a Sensitivity to the Statin Class of Host-Targeted Therapeutics. [PDF]

mSphere, 2019
Ahyong V, Berdan CA, Burke TP, Nomura DK, Welch MD.   +4 more
europepmc   +1 more source

Metallohelices that kill Gram-negative pathogens using intracellular antimicrobial peptide pathways

, 2019
Daniel H. Simpson, Alexia Hapeshi, Nicola J. Rogers, Viktor Brabec, Guy J. Clarkson, David J. Fox, Ondřej Hrabina, Gemma L. Kay, Andrew K. King, Jaroslav Malina, Andrew Millard, John Moat, David I. Roper, H. L. Song, Nicholas R. Waterfield, Peter Scott   +15 more
openalex   +2 more sources