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Membrane tethering in intracellular transport
Current Opinion in Cell Biology, 1999Studies of various membrane trafficking steps over the past year indicate that membranes are tethered together prior to the interaction of v-SNAREs and t-SNAREs across the membrane junction. The tethering proteins identified to date are quite large, being either fibrous proteins or multimeric protein complexes.
M G, Waters, S R, Pfeffer
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Intracellular sterol transport and distribution
Current Opinion in Cell Biology, 2006Sterols are important components of many biological membranes, and changes in sterol levels can have dramatic effects on membrane properties. Sterols are transported rapidly between cellular organelles by vesicular and nonvesicular processes. Recent studies have identified transmembrane proteins that facilitate the removal of sterols from membranes as ...
Frederick R, Maxfield, Anant K, Menon
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Intracellular cholesterol transport
1995Intracellular trafficking of cholesterol and various other sterols is important for cholesterol homeostasis of cells and the entire organism. Understanding the mechanisms involved in regulated, target-specific intracellular cholesterol transport is of great impact for understanding the pathogenesis of atherosclerosis and a number of inherited lipid ...
U. Seedorf +9 more
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Intracellular Transport of Pancreatic Enzymes
Scandinavian Journal of Gastroenterology, 1996Most pancreatic secretory proteins are packaged within the trans-Golgi network into zymogen granules, which are secreted in a regulated manner by exocytosis. But others enter alternative, constitutive-like pathways directed towards both apical and basolateral membranes.
L J, Cook, O A, Musa, R M, Case
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Cytoskeletal elements and intracellular transport
Journal of Cellular Biochemistry, 2007AbstractRecent advances in the understanding of the functions of various components of the cytoskeleton indicate that, besides serving a structural role, the cytoskeletal elements may regulate the transport of several proteins in the cell. Studies reveal that there are co‐operative interactions between the actin and microtubule cytoskeletons including ...
Lakshmi, Bhaskar +2 more
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Mechanisms of intracellular protein transport
Nature, 1994Recent advances have uncovered the general protein apparatus used by all eukaryotes for intracellular transport, including secretion and endocytosis, and for triggered exocytosis of hormones and neurotransmitters. Membranes are shaped into vesicles by cytoplasmic coats which then dissociate upon GTP hydrolysis.
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Intracellular Structure and Nucleocytoplasmic Transport
1996Intracellular movement of any solute or particle accords with one of two general schemes: either it takes place predominantly in the solution phase or it occurs by dynamic interactions with solid-state structures. If nucleocytoplasmic exchanges of macromolecules and complexes are predominantly solution-phase processes, i.e., if the former ...
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Integrative oncology: Addressing the global challenges of cancer prevention and treatment
Ca-A Cancer Journal for Clinicians, 2022Jun J Mao,, Msce +2 more
exaly
Mechanisms of Intracellular Organelle Transport
1984All eukaryotic cells exhibit some form of intracellular motility. The spectrum of motile activities observed inside living cells is extraordinarily broad, ranging from processes barely detectable even in time-lapse recordings, to the breathtaking bulk transport of cytoplasm best observed by slow-motion analysis.
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