Results 71 to 80 of about 334,616 (250)

Astrocytic Ion Dynamics: Implications for Potassium Buffering and Liquid Flow [PDF]

, 2019
We review modeling of astrocyte ion dynamics with a specific focus on the implications of so-called spatial potassium buffering, where excess potassium in the extracellular space (ECS) is transported away to prevent pathological neural spiking.
A Destexhe, A Louveau, A R Gardner-Medwin, AJ Smith, AS Thrane, B Frankenhaeuser, B Lu, BJ Tully, BV Safronov, C Nicholson, C Silberstein, CL Lopreore, CS Furman, DD Wang, E Lothman, E Syková, EA Newman, EA Newman, EH Park, ER Kandel, G Cordingley, G Einevoll, G Florence, G Halnes, G Halnes, G Rutkowska, G Ullah, Geir Halnes, Geir Halnes, GG Somjen, GG Somjen, H Kager, H Kager, H Zhang, HD Lux, I Østby, I. Dietzel, J Keyser De, J Pods, J Sibille, J Tong, J Ziburkus, JC Vardakis, JJ Iliff, JONATHAN A. COLES, JS Jung, K Støverud, K. Baber, KC Chen, L Hertz, L Odette, L Xie, L Øyehaug, M Amiry-Moghaddam, M Bai, M Hashido, M Léonetti, M Nedergaard, MA Biot, Matti Hämäläinen, MS Jensen, N Hübel, N Kríz, N Macaulay, N Qian, NN Haj-Yasein, NN Haj-Yasein, P Kofuji, Paul L. Nunez, PM Nanninga, R Enger, RK Orkand, Rune Enger, SB Hladky, T Grisar, Tina Pangršič, Y Zhang   +76 more
core   +2 more sources

Intracellular Transport: Kinesins Working Together [PDF]

Current Biology, 2008
While most in vitro experiments with motor proteins focus on the behavior of individual motors, in cells most cargo are transported by multiple motors and even multiple classes of motor. How these motors cooperate and compete in transporting cargo is not clear.
openaire   +2 more sources

Intracellular Metabolite Transporters in Plants [PDF]

Molecular Plant, 2010
Due to the presence of plastids, eukaryotic photosynthetic cells represent the most highly compartmentalized eukaryotic cells. This high degree of compartmentation requires the transport of solutes across intracellular membrane systems by specific membrane transporters.
Linka, Nicole, Weber, Andreas P.M.
openaire   +2 more sources

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

FEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga, Toshiki Takahashi, Akiko Kuma, Hiroyuki Kawahara   +3 more
wiley   +1 more source

Multi-modal transport and dispersion of organelles in narrow tubular cells

, 2017
Intracellular components explore the cytoplasm via active motor-driven transport in conjunction with passive diffusion. We model the motion of organelles in narrow tubular cells using analytical techniques and numerical simulations to study the ...
Koslover, Elena F., Mogre, Saurabh
core   +1 more source

Intracellular transport by active diffusion [PDF]

Trends in Cell Biology, 2009
All substances exhibit constant random motion at the microscopic scale. This is a direct consequence of thermal agitation, and leads to diffusion of molecules and small particles in a liquid. In addition to this nondirected motion, living cells also use active transport mechanisms, such as motor activity and polymerization forces that depend on linear ...
Brangwynne, C. P., Koenderink, G.H., Mac Kintosh, F.C., Weitz, D. A.   +3 more
openaire   +3 more sources

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

HyPer as a tool to determine the reductive activity in cellular compartments

Redox Biology
A multitude of cellular metabolic and regulatory processes rely on controlled thiol reduction and oxidation mechanisms. Due to our aerobic environment, research preferentially focuses on oxidation processes, leading to limited tools tailored for ...
Andrei Zhuravlev, Daria Ezeriņa, Julia Ivanova, Nikita Guriev, Natalia Pugovkina, Alla Shatrova, Nikolay Aksenov, Joris Messens, Olga Lyublinskaya   +8 more
doaj   +1 more source

Mechanism of NaCl transport-stimulated prostaglandin formation in MDCK cells [PDF]

, 1987
Recently we have found that stimulation of NaCl transport in high-resistance MDCK cells enhances their prostaglandin formation. In the present study, we investigated the mechanisms by which prostaglandin formation could be linked to the ion transport in ...
Bauer, C., Kurtz, Armin, Malmström, K., Pfeilschifter, J., Woodson, R. D.   +4 more
core   +1 more source

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source