Results 21 to 30 of about 2,108 (162)

Multimodal, longitudinal assessment of intracortical microstimulation [PDF]

, 2011
The fundamental obstacle to neuroprostheses based on penetrating microstimulation is the tissue's response to the device insertion and to the application of the electrical stimulation. Our long-term goal is to develop multichannel microstimulation of central nervous tissue for clinical therapy.
Koivuniemi, Andrew, Wilks, Seth J., Woolley, Andrew J., Otto, Kevin J.   +3 more
openaire   +5 more sources

Intracortical Microstimulation Modulates Cortical Induced Responses. [PDF]

J Neurosci, 2018
Recent advances in cortical prosthetics relied on intracortical microstimulation (ICMS) to activate the cortical neural network and convey information to the brain. Here we show that activity elicited by low-current ICMS modulates induced cortical responses to a sensory stimulus in the primary auditory cortex (A1).
Voigt MB, Yusuf PA, Kral A.
europepmc   +4 more sources

Electrochemical characterization and chronic stability of Utah electrode arrays for intracortical microstimulation. [PDF]

Front Neurosci
This study presents methods for evaluating the long-term electrochemical stability of Utah electrode arrays (UEAs) encapsulated with amorphous silicon carbide (a-SiC) or Parylene-C for intracortical microstimulation (ICMS).
Nguyen CK, Sturgill BS, Srikanthan B, Dousti B, Bhatt M, Khajehzadeh M, Mangarolia S, Hasan N, Hernandez-Reynoso AG, Negi S, Cogan SF.   +10 more
europepmc   +2 more sources

Neural mechanisms underlying intracortical microstimulation for sensory restoration. [PDF]

Nat Biomed Eng
Sensation plays a pivotal role in the orchestration of our daily lives. Intracortical microstimulation (ICMS) can elicit artificial sensations in persons who have lost sensation due to neurological injury or disease. Despite ongoing clinical studies to assess the safety and efficacy of ICMS, the mechanisms underlying neural activation by ICMS and their
Hughes C, Chen X, Grill W, Kozai TDY.
europepmc   +3 more sources

Local Neuronal Responses to Intracortical Microstimulation in Rats' Barrel Cortex Are Dependent on Behavioral Context. [PDF]

Front Behav Neurosci, 2022
The goal of cortical neuroprosthetics is to imprint sensory information as precisely as possible directly into cortical networks. Sensory processing, however, is dependent on the behavioral context.
Butovas S, Schwarz C.
europepmc   +2 more sources

Muscle synergies evoked by microstimulation are preferentially encoded during behavior [PDF]

Frontiers in Computational Neuroscience, 2014
Electrical microstimulation studies provide some of the most direct evidence for the neural representation of muscle synergies. These synergies, i.e. coordinated activations of groups of muscles, have been proposed as building blocks for the construction
Simon Alexander Overduin, Andrea eD'Avella, Jose M Carmena, Jose M Carmena, Jose M Carmena, Emilio eBizzi   +5 more
doaj   +2 more sources

The Long-Term Stability of Intracortical Microstimulation and the Foreign Body Response Are Layer Dependent. [PDF]

Front Neurosci, 2022
Intracortical microstimulation (ICMS) of the somatosensory cortex (S1) can restore sensory function in patients with paralysis. Studies assessing the stability of ICMS have reported heterogeneous responses across electrodes and over time, potentially ...
Urdaneta ME, Kunigk NG, Currlin S, Delgado F, Fried SI, Otto KJ.   +5 more
europepmc   +2 more sources

A computational model that predicts behavioral sensitivity to intracortical microstimulation. [PDF]

J Neural Eng, 2017
Intracortical microstimulation (ICMS) is a powerful tool to investigate the neural mechanisms of perception and can be used to restore sensation for patients who have lost it. While sensitivity to ICMS has previously been characterized, no systematic framework has been developed to summarize the detectability of individual ICMS pulse trains or the ...
Kim S, Callier T, Bensmaia SJ.
europepmc   +3 more sources

Conveying tactile object characteristics through customized intracortical microstimulation of the human somatosensory cortex. [PDF]

Nat Commun
Microstimulation of the somatosensory cortex can evoke tactile percepts in people with spinal cord injury, providing a means to restore touch. While location and intensity can be reliably conveyed, two issues that prevent creating more complex ...
Verbaarschot C, Karapetyan V, Greenspon CM, Boninger ML, Bensmaia SJ, Sorger B, Gaunt RA.   +6 more
europepmc   +3 more sources

The effect of chronic intracortical microstimulation on the electrode-tissue interface. [PDF]

J Neural Eng, 2014
Somatosensation is critical for effective object manipulation, but current upper limb prostheses do not provide such feedback to the user. For individuals who require use of prosthetic limbs, this lack of feedback transforms a mundane task into one that requires extreme concentration and effort.
Chen KH, Dammann JF, Boback JL, Tenore FV, Otto KJ, Gaunt RA, Bensmaia SJ.   +6 more
europepmc   +4 more sources