Results 41 to 50 of about 991 (131)

Mucinous cystic neoplasms and simple mucinous cysts are two distinct precursors of pancreatic cancer: clinicopathological, genomic, and transcriptomic characterization

The Journal of Pathology, Volume 266, Issue 4-5, Page 421-434, August 2025.
Abstract Mucinous cystic neoplasms (MCNs) of the pancreas are macroscopic precursors of pancreatic cancer. A similar cystic lesion but lacking the ovarian‐type subepithelial stroma has been recently defined as a simple mucinous cyst (SMC); however, its nature remains unclear. This study aims to define the clinicopathological and molecular profiles of a
Antonio Pea, Michele Bevere, Anastasios Gkountakos, Davide Pasini, Denise Fiorini, Andrea Mafficini, Stela Golovco, Michele Simbolo, Serena Pedron, Concetta Sciammarella, Paola Mattiolo, Aldo Mombello, Manuela Villanova, Carlotta Franzina, Francesca Masetto, Calogero Ciulla, Nicola Sperandio, Kohei Fujikura, Masha S. Ahadi, Jaswinder S. Samra, Amber L. Johns, Joanne Verheij, Martijn W.J. Stommel, Hjalmar van Santvoort, Leonor Schubert Santana, Giuseppe Malleo, Michele Milella, Lodewijk A. A. Brosens, Laura D. Wood, David K. Chang, Riccardo De Robertis, Mirko D'Onofrio, Anthony J. Gill, Roberto Salvia, Vincenzo Corbo, Rita T. Lawlor, Aldo Scarpa, Claudio Luchini   +37 more
wiley   +1 more source

Clinicopathological and molecular characterization of KRAS wild‐type pancreatic ductal adenocarcinomas reveals precursor lesions with oncogenic mutations and fusions in RAS pathway genes

The Journal of Pathology, Volume 266, Issue 3, Page 337-351, July 2025.
Abstract Pancreatic ductal adenocarcinomas (PDACs) with wild‐type KRAS constitute a small fraction of PDACs, and these tumors were recently shown to harbor frequent actionable oncogenic mutations and fusions. However, the clinicopathological features of KRAS wild‐type PDAC have not been well studied.
Kazuhiro Toriyama, Katsuhiro Masago, Noriko Shibata, Masataka Haneda, Takamichi Kuwahara, Seiji Natsume, Shota Kobayashi, Yasuko Fujita, Eiichi Sasaki, Kenji Yamao, Hiroki Kawashima, Yasuhiro Shimizu, Kazuo Hara, Yasushi Yatabe, Waki Hosoda   +14 more
wiley   +1 more source

Intraductal Oncocytic Papillary Neoplasm of the Pancreas: A Case of a Second Neoplasm in a Pancreas Cancer Survivor

JOP : Journal of the pancreas, 2015
JOP. Journal of the Pancreas, Vol 16, No 1 (2015): January - p.
Mrinal S, Garg, Theresa, Schuerle, Yulin, Liu, Shyam J, Thakkar   +3 more
openaire   +2 more sources

Real‐World Data Analysis of Genomic Alterations Detected by a Dual DNA–RNA Comprehensive Genomic Profiling Test

Cancer Science, Volume 116, Issue 7, Page 1984-1995, July 2025.
This study analyzed 1356 cases using GenMineTOP, Japan's first dual DNA–RNA CGP test, and identified oncogenic alterations in 91.5% of cases. The RNA panel detected 105 fusion events, including 11 NTRK fusions. Furthermore, the analysis clarified the independent effects of genomic abnormalities and cancer type on RNA expression, providing valuable ...
Kousuke Watanabe, Miho Ogawa, Aya Shinozaki‐Ushiku, Shuichi Tsutsumi, Kenji Tatsuno, Hiroyuki Aburatani, Hidenori Kage, Katsutoshi Oda   +7 more
wiley   +1 more source

Emerging pathological diagnostic strategies for solid pseudopapillary neoplasm of the pancreas: insights from omics and innovative techniques

The Journal of Pathology: Clinical Research, Volume 11, Issue 3, May 2025.
Abstract Solid pseudopapillary neoplasm (SPN) of the pancreas is a rare, low‐grade malignant tumor, representing 0.9–2.7% of all exocrine pancreatic tumors. SPN patients generally have a favorable prognosis with a 5‐year survival rate exceeding 95% following complete surgical resection.
Yuanhao Liu, Junya Peng, Yupei Zhao, Wenze Wang   +3 more
wiley   +1 more source

Update of newly‐recognized salivary gland neoplasms: molecular and immunohistochemical findings and clinical importance

Histopathology, Volume 86, Issue 2, Page 183-198, January 2025.
Molecular, immunohistochemical, and clinical understanding of salivary gland lesions has advanced in recent years, yielding reclassification and a shift in nomenclature of benign and malignant neoplasms. Pathogenic understanding, clinical treatment, and patient prognostication will improve with increasing knowledge of these diverse entities.
Rachelle A Wolk, Nicole A Cipriani
wiley   +1 more source

Gene Expression Profiling of Pancreatic Ductal Adenocarcinoma Arising From Intraductal Papillary Mucinous Neoplasms of the Pancreas

Cancer Medicine, Volume 13, Issue 23, December 2024.
Intraductal papillary mucinous neoplasms (IPMNs) are diverse premalignant tumors of the pancreas. They progress stepwise from adenoma to carcinoma and offer an opportunity for intervention prior to malignant transformation into pancreatic ductal adenocarcinoma (PDAC).
William A. Ziaziaris, Christopher S. H. Lim, Loretta Sioson, Anthony J. Gill, Jaswinder S. Samra, Sumit Sahni, Anubhav Mittal   +6 more
wiley   +1 more source

Invasive squamous cell carcinoma arising from an intraductal oncocytic papillary neoplasm demonstrating shared ATP1B1::PRKACA gene fusion

Human Pathology Reports
Intraductal oncocytic papillary neoplasms (IOPN) are rare cystic pancreatic neoplasms marked by oncocytic cells and intricate papillary structures.
Wai Szeto, Safa Alshaikh, Javier A. Arias-Stella, III, Yuman Fong, Rifat Mannan   +4 more
doaj   +1 more source

Expanding the spectrum of low‐grade sinonasal adenocarcinoma with biphasic seromucinous differentiation and activating HRAS/AKT1 mutations

Histopathology, Volume 85, Issue 6, Page 899-908, December 2024.
This work characterises four similar cases of low‐grade biphasic sinonasal adenocarcinoma harbouring activating HRAS mutations. Despite morphological and molecular overlaps with epithelial–myoepithelial carcinoma of the salivary glands, several arguments favour a distinct tumour entity originating from local seromucinous glands, i.e.
Viktoria S Hadnagy, Meike Körner, Matthias Rössle, Patrick Dubach, Gunther Pabst, Alexandra Kotulova, Stefan Weder, Robert Seifert, Elisabeth J Rushing, David Holzmann, Martin Hüllner, Sandra N Freiberger, Niels J Rupp   +12 more
wiley   +1 more source

Japanese classification of pancreatic carcinoma by the Japan Pancreas Society: Eighth edition

Journal of Hepato-Biliary-Pancreatic Sciences, Volume 31, Issue 11, Page 755-768, November 2024.
Ishida and colleagues report that the eighth edition of the Japanese classification of pancreatic carcinoma retains the T category, introduces new lymph node names, incorporates peritoneal cytology into the M category, and addresses endoscopic ultrasound‐guided fine‐needle aspiration biopsy and post‐therapy effects.
Masaharu Ishida, Tsutomu Fujii, Masashi Kishiwada, Kazuto Shibuya, Sohei Satoi, Makoto Ueno, Kohei Nakata, Shigetsugu Takano, Katsunori Uchida, Nobuyuki Ohike, Yohei Masugi, Toru Furukawa, Kenichi Hirabayashi, Noriyoshi Fukushima, Shuang‐Qin Yi, Hiroyuki Isayama, Takao Itoi, Takao Ohtsuka, Takuji Okusaka, Dai Inoue, Hirohisa Kitagawa, Kyoichi Takaori, Masaji Tani, Yuichi Nagakawa, Hideyuki Yoshitomi, Michiaki Unno, Yoshifumi Takeyama   +26 more
wiley   +1 more source