ABSTRACT Background Cholangiocarcinoma presents a global health challenge due to its increasing incidence and poor prognosis, primarily resulting from delayed diagnosis. There is an urgent need for a reliable biomarker to enhance early detection. Materials and Methods Patients with cholangiocarcinoma were enrolled into three cohorts: a discovery set (n
Lichieh Julie Chu+6 more
wiley +1 more source
Deep Learning for the Digital Pathologic Diagnosis of Cholangiocarcinoma and Hepatocellular Carcinoma: Evaluating the Impact of a Web-based Diagnostic Assistant [PDF]
While artificial intelligence (AI) algorithms continue to rival human performance on a variety of clinical tasks, the question of how best to incorporate these algorithms into clinical workflows remains relatively unexplored. We investigated how AI can affect pathologist performance on the task of differentiating between two subtypes of primary liver ...
arxiv
Nectin4‐targeted molecular imaging in solid tumors: Current status and future perspectives
In this review, we provide a concise overview of the mechanisms by which Nectin4 contributes to the pathogenesis of various malignancies and detail the classes of Nectin4‐targeted molecular probes. We then delve into the significant advancements in Nectin4‐targeted molecular imaging techniques, encompassing both nuclear medicine and optical imaging ...
Yongshun Liu+6 more
wiley +1 more source
Current principles for the surgical treatment of intrahepatic cholangiocarcinoma
Intrahepatic cholangiocarcinoma is one of the most aggressive forms of cancer. It is usually diagnosed in advanced stages of the disease, mainly because it is asymptomatic for a long time after the onset.
Catalin Savin+12 more
doaj +1 more source
Pituitary adenoma management and outcomes according to hospital case volume and facility type
Abstract Objectives This study evaluates the influence of facility volume and type on the treatment and outcomes of pituitary adenoma (PA). Methods The 2004–2016 National Cancer Database was queried for patients with PA receiving definitive treatment. Tumor size represented the largest diameter of the primary tumor.
Khodayar Goshtasbi+8 more
wiley +1 more source
Minute nodular intrahepatic cholangiocarcinoma. [PDF]
Masakazu Yamamoto+3 more
openalex +2 more sources
Does resection improve overall survival for intrahepatic cholangiocarcinoma with nodal metastases?
Background: The potential benefit of surgical resection of intrahepatic cholangiocarcinoma in patients with locoregionally advanced disease has not been definitively determined.
Patrick J. Sweigert, MD+7 more
doaj
Endoscopic management of primary sclerosing cholangitis
Primary sclerosing cholangitis (PSC) is a progressive autoimmune hepatobiliary disease characterized by fibrotic strictures in the bile ducts, leading to chronic cholestasis and cirrhosis. Magnetic resonance cholangiopancreatography (MRCP) is a noninvasive method for evaluating the condition of the bile ducts, and has high sensitivity and specificity ...
Suguru Mizuno+8 more
wiley +1 more source
Whole-exome sequencing reveals the origin and evolution of hepato-cholangiocarcinoma
Hepatocellular-cholangiocarcinoma (H-ChC) is a rare subtype of liver cancer with features of hepatocellular carcinoma and intrahepatic cholangiocarcinoma. Here, the authors utilize whole exome sequencing to highlight the monoclonal origin and stemness of
Anqiang Wang+11 more
doaj +1 more source
Endoscopic diagnosis of immunoglobulin G4‐related sclerosing cholangitis
Immunoglobulin G4 (IgG4)‐related sclerosing cholangitis (IgG4‐SC) is a distinct form of sclerosing cholangitis frequently associated with autoimmune pancreatitis and is recognized as a biliary manifestation of IgG4‐related disease. Endoscopic retrograde cholangiopancreatography (ERCP) and endoscopic ultrasonography (EUS) are key diagnostic modalities ...
Itaru Naitoh+2 more
wiley +1 more source