Results 11 to 20 of about 96,641 (177)

Tumor budding may be a promising prognostic indicator in intrahepatic cholangiocarcinoma: A multicenter retrospective study

Annals of Gastroenterological Surgery, Volume 7, Issue 1, Page 138-146, January 2023., 2023
High tumor budding is a new candidate for an additional determinant of the T category in staging ICC. An LCSGJ staging system containing an additional evaluation of tumor budding may lead to improved staging accuracy. Abstract Purpose This retrospective study evaluated our hypothesis that high tumor budding (≥10 buds) may help determine the appropriate
Hisashi Kosaka, Mitsuaki Ishida, Masaki Ueno, Koji Komeda, Daisuke Hokutou, Hiroya Iida, Fumitoshi Hirokawa, Kosuke Matsui, Mitsugu Sekimoto, Masaki Kaibori   +9 more
wiley   +1 more source

Cellular heterogeneity and transcriptomic profiles during intrahepatic cholangiocarcinoma initiation and progression

Hepatology, 2022
Intrahepatic cholangiocarcinoma (ICC) is not fully investigated, and how stromal cells contribute to ICC formation is poorly understood. We aimed to uncover ICC origin, cellular heterogeneity, and critical modulators during ICC initiation/progression ...
Tingjie Wang, Chuanrui Xu, Zhijing Zhang, Hua Wu, Xiujuan Li, Yu Zhang, Nan Deng, Ningxin Dang, G. Tang, Xiaofei Yang, B. Shi, Zihang Li, Lei Li, K. Ye   +13 more
semanticscholar   +1 more source

Dose of intra‐operative opioids has no impact on recurrence or survival in primary liver cancer

Cancer Medicine, Volume 11, Issue 24, Page 4927-4934, December 2022., 2022
Kaplan‐meier curves for recurrence‐free and overall survial of high‐dose and low‐dose groups. No significant difference in recurrence‐free survial (A) or overall survial (B) after surgery was noted when comparing high‐dose with low‐dose groups. Abstract Background Intra‐operative use of opioid analgesics might have an impact on cancer recurrence and ...
Liuyuan Zhao, Lei Teng, Wenhui Zhang, Shiyan Lin, Xuejiao Liu, Junzhu Dai, Hongxue Shao, Xiaoshi Li, Quan Liu, Huichao Zou   +9 more
wiley   +1 more source

Mesenchymal stem cells: A novel treatment option for primary sclerosing cholangitis

Cell Biology International, Volume 47, Issue 2, Page 467-479, February 2023., 2023
Abstract Primary sclerosing cholangitis (PSC) is a progressive liver disease for which there is no effective therapy. Hepatocytes and cholangiocytes from a PSC patient were cocultured with mesenchymal stem cells (MSCs) to assess in vitro change. A single patient with progressive PSC was treated with 150 million MSCs via direct injection into the common
Amy L. Lightner, Neda Dadgar, Anil Vaidya, Robert Simon, Clifton Fulmer, Hassan Siddiki, K. V. Narayanan Menon, Peter Liu, R. Matthew Walsh   +8 more
wiley   +1 more source

Cold plasma endoscopy applied to biliary ducts: feasibility risk assessment on human-like and porcine models for the treatment of cholangiocarcinoma [PDF]

J. Phys. D. Appl. Phys., Vol. 55, No 45, 2022, 2023
For the past twelve years, cold plasmas have been positioned as a breakthrough technology for treating cancer thanks to their antitumor properties. The innovation of ad hoc plasma sources and personalized protocols appears crucial to treat cancers with a very poor prognosis.
arxiv   +1 more source

Precision oncology for intrahepatic cholangiocarcinoma in clinical practice

British Journal of Cancer, 2022
Advanced cholangiocarcinoma has a poor prognosis. Molecular targeted approaches have been proposed for patients after progression under first-line chemotherapy treatment.
A. Tomczak, C. Springfeld, Michael T. Dill, D. Chang, D. Kazdal, Ursula Wagner, A. Mehrabi, Antje Brockschmidt, T. Luedde, P. Naumann, A. Stenzinger, P. Schirmacher, T. Longerich   +12 more
semanticscholar   +1 more source

The clinicopathological significance and relapse predictive role of tumor microenvironment of intrahepatic cholangiocarcinoma after radical surgery

Cancer, Volume 129, Issue 3, Page 393-404, 1 February 2023., 2023
Abstract Background This study attempts to detect the expression of FoxP3, CD68, CD8α, and PD‐L1 in the tumor microenvironment (TME) of intrahepatic cholangiocarcinoma (ICC), and analyze the relationship between the corresponding cells and clinicopathological characteristics as well as prognosis of ICC.
Yiling Zheng, Ning Huang, Shuwen Kuang, Jing Zhang, Hong Zhao, Jianxiong Wu, Mei Liu, Liming Wang   +7 more
wiley   +1 more source

The VEGF expression associated with prognosis in patients with intrahepatic cholangiocarcinoma: a systematic review and meta-analysis

World Journal of Surgical Oncology, 2022
Objective To systematically evaluate the relationship between vascular endothelial growth factor (VEGF) and prognosis of intrahepatic cholangiocarcinoma by meta-analysis.
C. Cai, Xiaojing Wang, Qiurong Fu, Ai-ni Chen   +3 more
semanticscholar   +1 more source

Diagnostic pitfalls and the value of fluorescence in situ hybridization as an adjunct to cytologic evaluation of bile duct brushings in patients with primary sclerosing cholangitis

Diagnostic Cytopathology, Volume 51, Issue 2, Page 117-122, February 2023., 2023
Abstract Background Primary sclerosing cholangitis (PSC) can present diagnostic difficulties on bile duct brushings as cytologic features mimicking adenocarcinoma may exist. This study evaluates the role of fluorescence in‐situ hybridization (FISH) as an adjunct to cytologic evaluation.
Suzanne M. Selvaggi
wiley   +1 more source

Influence of portal vein occlusion on portal flow and liver elasticity in an animal model [PDF]

NMR in Biomedicine, Wiley, 2021, pp.e4498, 2021
Hepatic fibrosis causes an increase in liver stiffness, a parameter measured by elastography and widely used as a diagnosis method. The concomitant presence of portal vein thrombosis (PVT) implies a change in hepatic portal inflow that could also affect liver elasticity.
arxiv   +1 more source