Results 31 to 40 of about 2,032 (137)

Structural Characterization and Physicochemical Property of a Purified Fucosylated Glycosaminoglycan Sulfate From Holothuria leucospilota

eFood, Volume 6, Issue 4, August 2025.
(1) The main chain structure of Holothuria leucospilota polysaccharides (HLP‐Ⅰ) was presumed to be roughly as →3)‐β‐d‐GalpNAc‐(1→4)‐β‐d‐GlcpA‐(1→. (2) with T‐Fucp on the branched chain or a rockulose chain consisting of →3,4)‐α‐l‐Fucp‐(1→. (3) HLP‐Ⅰ showed high amorphous platelet content and disordered arrangement, while the molecule adapted a sphere ...
Wanting Wang, Kexue Zhu, Jun Cao, Shunjiang Zeng, Lijun You, Chao Zhao, Yuanping Zheng, Chuan Li   +7 more
wiley   +1 more source

Synthesis, Antimycobacterial Activity, and Computational Insight of Novel 1,4‐Benzoxazin‐2‐one Derivatives as Promising Candidates against Multidrug‐Resistant Mycobacterium Tuberculosis

ChemMedChem, Volume 20, Issue 14, July 18, 2025.
A series of 14 novel 1,4‐benzoxazinone derivatives is tested against various strains of Mycobacterium tuberculosis. All compounds show high activity against all tested strains, particularly the resistant strains. Additionally, the novel derivatives exhibit low cytotoxicity toward mammalian Vero cells.
Maria Grazia Mamolo, Emanuele Carosati, Diletta Pasin, Alessandro De Logu, Gianluigi Cabiddu, Marko Jukič, Daniele Zampieri   +6 more
wiley   +1 more source

Quantitative comparison of catalytic mechanisms and overall reactions in convergently evolved enzymes : implications for classification of enzyme function [PDF]

, 2010
The authors thank the National Institutes of Health (NIH R01 GM60595 to PCB) and the Scottish Universities Life Sciences Alliance (SULSA to JBOM) for funding.Functionally analogous enzymes are those that catalyze similar reactions on similar substrates ...
Daniel E. Almonacid, Emmanuel R. Yera, John B. O. Mitchell, Patricia C. Babbitt, Christine A. Orengo, RA George, JA Gerlt, PC Babbitt, JA Gerlt, ME Glasner, GJ Bartlett, MY Galperin, H Hegyi, ACR Martin, PF Gherardini, AE Todd, AE Todd, Z Zhang, S Tsoka, SA Teichmann, TD Otto, NH Horowitz, RA Jensen, GA Petsko, RA Chiang, CS Wright, BW Matthews, SC Morris, N Nagano, CT Porter, C Andreini, C Andreini, GL Holliday, GL Holliday, SC-H Pegg, SC-H Pegg, N Nagano, AG Murzin, G Ausiello, H Berman, NM O'Boyle, P Jaccard, P Willett, TF Smith, CA Orengo, AG McDonald, ACR Martin, SB Needleman, M Kotera, Y Yamanishi, GL Holliday, L Maveyraud, J Pitarch, R Castillo, JC Hermann, Z Wang, AP Leech, DG Gourley, AW Roszak, LM Blomberg, A Matte, MM Benning, PC Babbitt, DL Scott, BW Segelke, YS Ho, YS Ho, ME Lowe, Y Bourne, RJ Kazlauskas, H van Tilbeurgh, GJ Bartlett, T Nakai, A Zajc, E Ortlund, AB Hickman, TJ Wyckoff, CR Sweet, W Plaga, V Leppänen, F Himo, M Mathieu, Y Modis, RF Doolittle, V Sangar, BE Shakhnovich, PW Lord, J Gasteiger, O Sacher, DARS Latino, DARS Latino, DARS Latino, Y Loewenstein, T Dandekar, R Overbeek, AJ Enright, EM Marcotte, M Pellegrini, JC Hermann, JC Hermann, ME Glasner, L Jiang, M Bashton, K Tipton, KA Olszewski, R Preißner, J Park, PR Mittl, S Lorenzen, A Fersht, M Errami, EO Cannon, M Rizzi, J Symersky, Y Devedjiev, AR Battersby, N Frankenberg, MA Mathews, HL Schubert, B Stec, L Ma, JE Murphy, EB Fauman, RH Hoff, F Wang   +124 more
core   +3 more sources

Ecogenomics and limnological dynamics of a new Thiocapsa species blooming in the whole water column of a karstic lake

Limnology and Oceanography, Volume 70, Issue 7, Page 1849-1866, July 2025.
Abstract Purple sulfur bacteria (PSB) of the family Chromatiaceae (Gammaproteobacteria) can perform chemo‐ and photo‐lithoautotrophy (through anoxygenic photosynthesis) in anoxic layers of freshwater stratified (including meromictic) lakes. This group has been extensively studied via physiological and ecological approaches, albeit their genomics has ...
Pedro J. Cabello‐Yeves, Antonio Picazo, Carlos Rochera, Daniel Morant, Eduardo Vicente, David J. Scanlan, Richard J. Puxty, Antonio Camacho   +7 more
wiley   +1 more source

Recent trends in whole cell and isolated enzymes in enantioselective synthesis [PDF]

, 2011
Modern synthetic organic chemistry has experienced an enormous growth in biocatalytic methodologies; enzymatic transformations and whole cell bioconversions have become generally accepted synthetic tools for asymmetric synthesis.
Maguire, Anita R., Milner, Sinéad E.
core   +1 more source

Identification of chemically sulfated/desulfated glycosaminoglycans in contaminated heparins and development of a simple assay for the detection of most contaminants in heparin [PDF]

, 2010
Contaminated heparin was linked to at least 149 deaths and hundreds of adverse reactions. Published report indicates that heparin contaminants were a natural impurity, dermatan sulfate, and a contaminant, oversulfated chondroitin sulfate (OSCS). OSCS was
Frazier, Sarah B, Lu, Hong, Pan, Jing, Pazandak, Andrew, Qian, Yi, Weiser, Peter, Zhang, Lijuan, Zhou, Xiaodong   +7 more
core   +1 more source

Purine Chemistry in the Early RNA World at the Origins of Life: From RNA and Nucleobases Lesions to Current Key Metabolic Routes

ChemBioChem, Volume 26, Issue 11, June 3, 2025.
In the nascent processes of the beginnings and evolution of life, nucleobases and especially purines, ribonucleos(t)ides and primitive RNAs have been continuously modified. A RNA‐peptide world and key metabolic pathways probably have emerged from the corresponding chemical modifications resulting from adenine deamination, purine alkylation and ...
Jean‐Luc Décout, Marie‐Christine Maurel   +1 more
wiley   +1 more source

How members of the human gut microbiota overcome the sulfation problem posed by glycosaminoglycans [PDF]

, 2017
The human microbiota, which plays an important role in health and disease, uses complex carbohydrates as a major source of nutrients. Utilization hierarchy indicates that the host glycosaminoglycans heparin (Hep) and heparan sulfate (HS) are high ...
Alan Cartmell, Arnaud Baslé, Bernard Henrissat, David N. Bolam, Didier A. Ndeh, Elisabeth C. Lowe, Harry J. Gilbert, Heath Murray, Jeremy E. Turnbull, Mirjam Czjzek, Ndeh, Nicolas Terrapon, Oshiro, Susan J. Firbank, Vincent Lombard   +14 more
core   +3 more sources

Designing Enzymatic Reactivity with an Expanded Palette

ChemBioChem, Volume 26, Issue 11, June 3, 2025.
Innovation in biocatalysis is rapidly increasingly the diversity of catalytic reactivity that can be mediated by enzymes, addressing a key bottleneck for their widespread adoption in industrial chemical synthesis. A key approach to this is building enzymes with unnatural catalytic components that provide an expanded palette with new possibilities for ...
Reuben B. Leveson‐Gower
wiley   +1 more source

Elucidating the Mechanism of Temporal Adaptation to Hydrogen Peroxide‐Induced Oxidative Stress in Corynebacterium glutamicum

Microbial Biotechnology, Volume 18, Issue 6, June 2025.
In this study, RNA‐seq was employed to investigate the temporal transcriptional response of C. glutamicum ATCC 13032 to external H2O2 at 720 mM (2.45% w/w). The results reveal significant changes in gene expression across multiple pathways, including peroxide scavenging, central metabolism, sulphur and iron metabolism, amino acid biosynthesis, and DNA ...
Chang Yu, Wenjing Hu, Xiaoyu Li, Yu Lei, Dandan Gao, Meng Wang, Ping Zheng, Yan Zhu, Jibin Sun   +8 more
wiley   +1 more source