Results 51 to 60 of about 2,144 (137)
Molecular Microbiology, Volume 124, Issue 3, Page 204-220, September 2025.In Hyphomicrobium denitrificans, the use of thiosulfate as a supplemental electron donor is regulated by two homologous sulfane‐sulfur responsive ArsR‐type transcriptional repressors, sHdrR and SoxR, that act cooperatively. Remarkably, the regulation by sHdrR/SoxR extends far beyond sulfur oxidation and deeply affects anaerobic metabolism, particularly
Jingjing Li +3 more
wiley +1 more source
ChemBioChem, Volume 26, Issue 15, August 22, 2025.A putative thrazarine biosynthetic gene cluster is discovered in the genome sequence of Streptomyces coerulescens MH802‐fF5. In vivo and in vitro analyses of ThzN, a hydrazine synthetase with cupin and methionyl‐tRNA synthetase‐like domains encoded in the cluster, showed that it synthesizes a key intermediate of thrazarine by catalyzing condensation ...
Yusuke Shikai +4 more
wiley +1 more source
Characterization of C-S Lyase from C. diphtheriae [PDF]
, 2013 The emergence of antibiotic resistance in microbial pathogens requires the identification of new antibacterial drugs. The biosynthesis of methionine is an attractive target because of its central importance in cellular metabolism.
Allegrini, Alessandra +4 more
core +1 more source
FEBS Letters, Volume 599, Issue 15, Page 2201-2209, August 2025.Dimeric pyruvate formate‐lyase cleaves pyruvate using a radical‐based mechanism. G734 serves as a radical storage location, and the radical is transferred to the catalytic C419 residue. Mutation of the C418‐C419 pair causes loss of enzyme activity, but does not impede radical introduction onto G734. Therefore, cis‐ but not trans‐radical transfer occurs
Michelle Kammel +2 more
wiley +1 more source
Expanding the Biocatalytic Toolbox of C-N Lyases:Rational Engineering and Enzyme Discovery [PDF]
With the growing demand for nonhazardous and sustainable alternatives for chemical catalysis, interest in biocatalysts has grown significantly over the past decades. The enzyme ethylenediamine-N,N’-succinic acid (EDDS) lyase from Chelativorans sp.
Bothof, Laura
core +1 more source
An Enzymatic Prodrug‐like Route to Thio and Selenoamides [PDF]
6‐Thioguanine (6TG) is a clinically used antitumor agent that was rationally designed as a DNA‐targeting antimetabolite, but it also occurs naturally. 6TG is a critical virulence factor produced by Erwinia amylovorans , a notorious plant pathogen that ...
Dunbar, Kyle L. +3 more
core +1 more source
COMPARATIVE APPROACHES FOR PLANT GENOMES: UNRAVELING "INTRA" AND "INTER" SPECIES RELATIONSHIPS FROM PRELIMINARY GENE ANNOTATIONS [PDF]
, 2016 Comparative genomics studies the differences and similarities between different species, to transfer biological information from model organisms to newly sequenced genomes, and to understand the evolutionary forces that drive changes in genomic features ...
Ambrosino, Luca
core
Bacterial hemoglobins and flavohemoglobins: versatile proteins and their impact on microbiology and biotechnology [PDF]
, 2017 In response to oxygen limitation or oxidative and nitrosative stress, bacteria express three kinds of hemoglobin proteins: truncated hemoglobins (tr Hbs), hemoglobins (Hbs) and flavohemoglobins (flavo Hbs).
Frey, Alexander D., Kallio, Pauli T.
core
Quantitative and evolutionary global analysis of enzyme reaction mechanisms [PDF]
, 2015 The most widely used classification system describing enzyme-catalysed reactions is the Enzyme Commission (EC) number. Understanding enzyme function is important for both fundamental scientific and pharmaceutical reasons.
Nath, Neetika
core
Function and redox state of mitochondrial localized cysteine-rich proteins important in the assembly of cytochrome \u3ci\u3ec\u3c/i\u3e oxidase [PDF]
, 2008 The cytochrome c oxidase (CcO) complex of the mitochondrial respiratory chain exists within the mitochondrial inner membrane (IM). The biogenesis of the complex is a multi-faceted process requiring multiple assembly factors that function on both faces of
Khalimonchuk, Oleh, Winge, Dennis R.
core +1 more source