Results 101 to 110 of about 9,767 (210)

Why Osteosarcopenia Matters: Clinical and Investigative Implications

open access: yesEuropean Journal of Clinical Investigation, Volume 56, Issue 5, May 2026.
Osteosarcopenia: Non‐pharmacological and pharmacological treatment strategies. ABSTRACT Background Osteosarcopenia, the combination of osteoporosis and sarcopenia, is a geriatric syndrome linked to functional decline, falls, and fragility fractures. The interaction among bone, muscle, and their shared pathophysiology is driven by mechanical, metabolic,
Erik Luiz Bonamigo   +5 more
wiley   +1 more source

Gene expression identifies metabolic and functional differences between intramuscular and subcutaneous adipocytes in cattle [PDF]

open access: yesBMC Genomics, 2019
Abstract Background This study used a genome-wide screen of gene expression to better understand the metabolic and functional differences between commercially valuable intramuscular fat (IMF) and commercially wasteful subcutaneous (SC) fat depots in Bos taurus beef cattle.Results We confirmed many findings previously made at the biochemical ...
Nicholas J. Hudson   +8 more
openaire   +6 more sources

Systemic adiponectin malfunction as a risk factor for cardiovascular disease. [PDF]

open access: yes, 2011
Adiponectin (Ad) is an abundant protein hormone regulatory of numerous metabolic processes. The 30 kDa protein originates from adipose tissue, with full-length and globular domain circulatory forms.
Lau, Wayne Bond   +4 more
core   +2 more sources

Lipid emulsion modulates myogenic and collagen‐related gene expression in skeletal muscle of preterm fetal sheep

open access: yesExperimental Physiology, Volume 111, Issue 5, Page 2627-2636, 1 May 2026.
Abstract Although intravenous lipid emulsions are routinely administered to preterm infants, their specific effects on skeletal muscle development remain unclear. In this study, a soybean oil‐based lipid emulsion (Intralipid 20®) was administered via intravenous infusion to fetal sheep (gestational day 88–90) at a dose rising from 1 g/kg/day (day 0) to
Xinrui Li   +5 more
wiley   +1 more source

Bta-miR-376a Targeting KLF15 Interferes with Adipogenesis Signaling Pathway to Promote Differentiation of Qinchuan Beef Cattle Preadipocytes

open access: yesAnimals, 2020
Intramuscular fat (IMF) is a quality index associated with the taste and juiciness of meat. The deposition of IMF is affected by genetic and non-genetic factors, such as age, slaughter location, gender of the animal, and diet.
Xingyi Chen   +5 more
doaj   +1 more source

Cells and ionic conductances contributing to spontaneous activity in bladder and urethral smooth muscle

open access: yesThe Journal of Physiology, Volume 604, Issue 9, Page 3611-3632, 1 May 2026.
Abstract figure legend Cells and conductances contributing to spontaneous activity in the lower urinary tract. Bladder and urethra exhibit spontaneous contractions at both cellular and tissue levels. Both detrusor and urethral smooth muscle cells display activity that is regular and rhythmic.
Bernard T. Drumm   +3 more
wiley   +1 more source

Reduced Muscular Carnosine in Proximal Myotonic Myopathy—A Pilot 1H‐MRS Study

open access: yesAnnals of Clinical and Translational Neurology, Volume 13, Issue 4, Page 788-795, April 2026.
ABSTRACT Objective Myotonic dystrophy type 2 (proximal myotonic myopathy, PROMM) is a progressive multisystem disorder with muscular symptoms (proximal weakness, pain, myotonia) and systemic manifestations such as diabetes mellitus, cataracts, and cardiac arrhythmias.
Alexander Gussew   +11 more
wiley   +1 more source

Regression-based approach for testing the association between multi-region haplotype configuration and complex trait [PDF]

open access: yes, 2009
Background It is quite common that the genetic architecture of complex traits involves many genes and their interactions. Therefore, dealing with multiple unlinked genomic regions simultaneously is desirable. Results In this paper we develop a regression-
Yanling Hu   +7 more
core   +2 more sources

PIK3CA Mutations Downregulate PPT1 to Promote Adipogenesis by Suppressing P300 Depalmitoylation and Phase Separation

open access: yesAdvanced Science, Volume 13, Issue 19, 2 April 2026.
This study demonstrates that somatic PIK3CA mutations suppress PPT1 expression via activation of the PI3K–AKT–c‐JUN axis. This reduction in PPT1 weakens its interaction with P300, thereby increasing palmitoylation at C1176 of P300 and protecting P300 from lysosomal degradation.
Hongrui Chen   +7 more
wiley   +1 more source

Home - About - Disclaimer - Privacy