Results 111 to 120 of about 9,759 (242)

Therapeutic Effects of Noninvasive Electrical Stimulation in Combination Transplantation of Human Adipose‐Derived Stem Cells‐Derived Dopaminergic Neuron on the Monkey Model of Parkinson's Disease

open access: yesMedComm, Volume 7, Issue 2, February 2026.
Our results showed that noninvasive electrical stimulation (NES) alone or in combination with human adipose‐derived stem cells (hADSCs)‐induced dopaminergic neuron (NES‐DN) improved the behavioral deficits and pathological features of the MPTP‐induced PD monkey model.
Chunhui Huang   +21 more
wiley   +1 more source

Stem Cell Secretome Treatment Reduces Adiposity and Improves Glucose Handling During Obesity and Weight Loss in Mice

open access: yesObesity, Volume 34, Issue 2, Page 382-393, February 2026.
ABSTRACT Objective In this study, we investigated the effects of a stem cell‐derived secretome product on adiposity and tissue quality and insulin and glucose levels in obese mice and those undergoing dietary weight loss. Methods Following 16 weeks of high fat diet mice received acute (4 weeks) biweekly intramuscular injections with vehicle or ...
Zachary J. Fennel   +11 more
wiley   +1 more source

Allogeneic mesenchymal stromal cells overexpressing mutant human Hypoxia-inducible factor 1-α (HIF1-α) in an ovine model of acute myocardial infarction [PDF]

open access: yes, 2016
Background-Bone marrow mesenchymal stromal cells (BMMSCs) are cardioprotective in acute myocardial infarction (AMI) because of release of paracrine angiogenic and prosurvival factors.
Crottogini, Alberto José   +11 more
core   +1 more source

Optimization of the Nonclinical Biological Evaluation of Medical Devices Using Toxicologic Pathology Best Practices

open access: yesAdvanced Healthcare Materials, Volume 15, Issue 3, 19 January 2026.
Nonclinical evaluation of biological responses to implanted medical devices and combination products in animals is required to predict possible outcomes and risks in patients. This paper describes globally accepted pathology “best practices” that 1) effectively address ISO standards and current regulatory guidance for medical device development and 2 ...
Kathleen A. Funk   +6 more
wiley   +1 more source

Bta-miR-376a Targeting KLF15 Interferes with Adipogenesis Signaling Pathway to Promote Differentiation of Qinchuan Beef Cattle Preadipocytes

open access: yesAnimals, 2020
Intramuscular fat (IMF) is a quality index associated with the taste and juiciness of meat. The deposition of IMF is affected by genetic and non-genetic factors, such as age, slaughter location, gender of the animal, and diet.
Xingyi Chen   +5 more
doaj   +1 more source

The assembly of lipid droplets and its relation to cellular insulin sensitivity [PDF]

open access: yes, 2009
Udgivelsesdato: OctThe assembly of lipid droplets is dependent on PtdIns(4,5)P(2) that activates PLD(1) (phospholipase D(1)), which is important for the assembly process.
Andersson, Linda   +6 more
core   +1 more source

TSHR‐Targeting Nucleic Acid Aptamer Treats Graves' Ophthalmopathy via Novel Allosteric Inhibition

open access: yesAdvanced Science, Volume 13, Issue 4, 19 January 2026.
This study presents YC3, a novel inhibitory TSHR‐targeting aptamer, as a promising therapeutic for Graves' ophthalmopathy (GO). YC3 suppresses pathological phenotypes in human orbital fibroblasts and improves outcomes in GO mice by binding to a previously unidentified allosteric site on TSHR, demonstrating the potential of aptamers in advancing ...
Yanchen Zhang   +16 more
wiley   +1 more source

Genetic parameters of mule ducks meat and fatty liver performances simultaneously estimated in both parental liness : [Preprint] [PDF]

open access: yes, 2009
Genetic parameters of traits related to hepatic lipid metabolism, carcass composition and products quality of overfed mule ducks were estimated on both parental lines of this hybrid: the "common duck" line (C), for the maternal side and the "Muscovy ...
André, J.M.   +11 more
core  

Regenerative Approach With Autologous Fat Grafting and Stem Cells for the Treatment of Post‐Traumatic Anal Incontinence: A Case Report

open access: yesClinical Case Reports, Volume 14, Issue 1, January 2026.
ABSTRACT Autologous fat grafting enriched with mesenchymal stem cells is a promising minimally invasive regenerative therapy for post‐traumatic anal incontinence. This approach may restore continence and quality of life, even when structural sphincter defects persist.
Alexandre da Silva Nishimura   +6 more
wiley   +1 more source

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