Results 31 to 40 of about 140,818 (295)

Intranasal Insulin for Alzheimer’s Disease

CNS Drugs, 2021
Brain insulin signaling contributes to memory function and might be a viable target in the prevention and treatment of memory impairments including Alzheimer’s disease.
M. Hallschmid
semanticscholar   +1 more source

Intranasal delivery of a chimpanzee adenovirus vector expressing a pre-fusion spike (BV-AdCoV-1) protects golden Syrian hamsters against SARS-CoV-2 infection

Frontiers in Cellular and Infection Microbiology, 2022
We evaluated the immunogenicity and protective ability of a chimpanzee replication-deficient adenovirus vectored COVID-19 vaccine (BV-AdCoV-1) expressing a stabilized pre-fusion SARS-CoV-2 spike glycoprotein in golden Syrian hamsters.
Shen Wang, Long Xu, Ting Mu, Mian Qin, Ping Zhao, Liang Xie, Linsen Du, Yue Wu, Nicolas Legrand, Karine Mouchain, Guillaume Fichet, Yi Liu, Yi Liu, Wenhao Yin, Jin Zhao, Min Ji, Bo Gong, Michel Klein, Michel Klein, Ke Wu, Ke Wu   +20 more
doaj   +1 more source

An intranasal vaccine durably protects against SARS-CoV-2 variants in mice

bioRxiv, 2021
SARS-CoV-2 variants that attenuate antibody neutralization could jeopardize vaccine efficacy and the end of the COVID-19 pandemic. We recently reported the protective activity of a single-dose intranasally-administered spike protein-based chimpanzee ...
Ahmed O. Hassan, S. Shrihari, M. Gorman, Baoling Ying, D. Yuan, S. Raju, Rita E. Chen, I. Dmitriev, E. Kashentseva, L. Adams, P. Shi, D. Fremont, D. Curiel, G. Alter, M. Diamond   +14 more
semanticscholar   +1 more source

Comparison of intranasal midazolam versus intranasal ketamine for preoperative anesthetic sedation in pediatric patients

The Indian Anaesthetists' Forum, 2020
Introduction: During induction of anesthesia anxiety of children may be reduced more effectively by sedative medication than parental presence. Keeping in view, the necessity of reducing preoperative anxiety and postoperative psychological problem in ...
Nandini Chouhan, Janhavi Thatte, Deepak Phalgune, Charushila Patkar   +3 more
doaj   +1 more source

An Intranasal OMV-Based Vaccine Induces High Mucosal and Systemic Protecting Immunity Against a SARS-CoV-2 Infection

bioRxiv, 2021
The development of more effective, accessible and easy to administer COVID-19 vaccines next to the currently marketed mRNA, viral vector and whole inactivated vaccines, is essential to curtain the SARS-CoV-2 pandemic.
P. van der Ley, A. Zariri, E. van Riet, D. Oosterhoff, C. Kruiswijk   +4 more
semanticscholar   +1 more source

Intranasal esketamine as therapeutic option: a case report of an adolescent with treatment resistant depression

Frontiers in Psychiatry, 2023
Depression is among the most common mental health disorders worldwide and treatment resistant depression (TRD) represents a major challenge for both patients and clinicians.
Katrin Skala, Kamer Doganay, Harald Eder, Dunja Mairhofer, Katrin Neubacher, Paul L. Plener, Paul L. Plener   +6 more
doaj   +1 more source

Case report: Intramuscular ketamine or intranasal esketamine as a treatment in four patients with major depressive disorder and comorbid anorexia nervosa

Frontiers in Psychiatry, 2023
IntroductionA comorbid diagnosis of a depressive disorder is a negative prognostic factor for individuals with AN, and novel treatments are needed to target depressive symptoms in this population. One emerging promising treatment for depressive disorders
Johanna Louise Keeler, Janet Treasure, Janet Treasure, Hubertus Himmerich, Hubertus Himmerich, Madeline Brendle, Madeline Brendle, Claire Moore, Reid Robison, Reid Robison   +9 more
doaj   +1 more source

Brain Targeting of Quetiapine Fumarate via Intranasal Delivery of Loaded Lipospheres: Fabrication, In-Vitro Evaluation, Optimization, and In-Vivo Assessment

Pharmaceuticals, 2022
A liposphere system for intranasal delivery of quetiapine fumarate (QTF) was created to assess the potential for enhanced drug delivery. We investigated the effects of particle size, entrapment effectiveness, poly dispersibility index, and pluronic ...
Randa Mohammed Zaki, Mohammed F. Aldawsari, Manal A. Alossaimi, Shaikah F. Alzaid, Vidya Devanathadesikan Seshadri, Alanood S. Almurshedi, Basmah Nasser Aldosari, Rehab Mohammad Yusif, Ossama M. Sayed   +8 more
doaj   +1 more source

Ameliorating Impact of Prophylactic Intranasal Oxytocin on Signs of Fear in a Rat Model of Traumatic Stress

Frontiers in Behavioral Neuroscience, 2018
Oxytocin treatment reduces signs of long-term emotional stress after exposure to trauma; however, little is known about the potential protective effects of oxytocin treatment on behavioral and physiological changes associated with extreme stress exposure.
Micah D. Renicker, Nicholas Cysewski, Samuel Palmer, Dmytro Nakonechnyy, Andrew Keef, Morgan Thomas, Krisztian Magori, David P. Daberkow   +7 more
doaj   +1 more source

Intranasal Delivery: Effects on the Neuroimmune Axes and Treatment of Neuroinflammation

Pharmaceutics, 2020
This review highlights the pre-clinical and clinical work performed to use intranasal delivery of various compounds from growth factors to stem cells to reduce neuroimmune interactions.
Elizabeth M. Rhea, Aric F. Logsdon, William A. Banks, Michelle E. Erickson   +3 more
doaj   +1 more source