Results 91 to 100 of about 2,191,985 (278)

AAV vector distribution in the mouse respiratory tract following four different methods of administration

BMC Biotechnology, 2017
Background Targeted delivery of gene therapy vectors to the mouse respiratory tract is often performed via intranasal or intratracheal administration; however, there can be a great deal of variability between these methods, which could potentially ...
Lisa A. Santry, Joelle C. Ingrao, Darrick L. Yu, Jondavid G. de Jong, Laura P. van Lieshout, Geoffrey A. Wood, Sarah K. Wootton   +6 more
doaj   +1 more source

Clinical efficacy of dexmedetomidine combined with sevoflurane sedation in pediatric MRI scanning

Di-san junyi daxue xuebao, 2020
Objective To observe the sedation effect and safety of intranasal dexmedetomidine in combination with sevoflurane inhalation for pediatric patients undergoing magnetic resonance imaging(MRI).
ZHANG Tiange, TANG Wen, XU Ying, LIU Fengzhi, PENG Yinjuncheng, LIU Wei   +5 more
doaj   +1 more source

Rapid transport of insulin to the brain following intranasal administration in rats

Neural Regeneration Research, 2019
We previously reported that intranasal insulin protects substantia nigra dopaminergic neurons against 6-hydroxydopamine neurotoxicity in rats. This study aimed to assess insulin pharmacokinetics in the rat brain following intranasal application ...
L. Fan, Kathleen Carter, A. Bhatt, Y. Pang   +3 more
semanticscholar   +1 more source

Intranasal application of vasopressin fails to elicit changes in brain immediate early gene expression, neural activity and behavioral performance of rats [PDF]

, 2013
Intranasal administration has been widely used to investigate effects of the neuropeptides vasopressin and oxytocin on human behaviors and neurological disorders, but exactly what happens when these neuropeptides are administered intranasally is far from
Andreae, Appenrodt, Bales, Born, Chen, Churchland, Costa, Danguir, Dantzer, Denenberg, Dluzen, Donaldson, Engelmann, Engelmann, Engelmann, Ermisch, Fjellestad-Paulsen, Ganten, Giri, Goodson, Gouzenes, Graff, Guastella, Gutkowska, Hanson, Heinrichs, Hendricks, Hernando, Hoover, Huntingford, Insel, Ionescu, Jiang, Kandimalla, Kita, Klimkiewicz, Knopf, Landgraf, Landgraf, Levasseur, Lloyd, Ludwig, Lukas, Lund, MacDonald, Mens, Meyer-Lindenberg, Minn, Moal, Moal, Neumann, Newton, Noble, Olson, Paban, Petersson, Petty, Porges, Poulin, Ross, Sarkar, Seckl, Thorne, Thorne, Tobin, Wakerley, Wall, Watelet, Wied, Windle, Wioland, Young, Yu   +72 more
core   +1 more source

Intranasal administration of the chemotherapeutic perillyl alcohol results in selective delivery to the cerebrospinal fluid in rats

Scientific Reports, 2021
Perillyl alcohol (POH) has been extensively studied for the treatment of peripheral and primary brain tumors. The intranasal route of administration has been preferred for dosing POH in early-stage clinical trials associated with promising outcomes in ...
Geetika Nehra, Shannon Andrews, Joan Rettig, Michael N. Gould, Jill D. Haag, Steven P. Howard, Robert G. Thorne   +6 more
doaj   +1 more source

The short-term and long-term effects of intranasal mesenchymal stem cell administration to noninflamed mice lung [PDF]

, 2022
Marlena Tynecka, Adrian Janucik, Magdalena Niemira, Arkadiusz Żbikowski, Nino Stocker, Agnieszka Tarasik, Aleksandra Starosz, Kamil Grubczak, Anna Szałkowska, Urszula Korotko, Joanna Reszeć, Mirosław Kwaśniewski, Adam Krętowski, Cezmi A. Akdiş, Milena Sokołowska, Marcin Moniuszko, Andrzej Eljaszewicz   +16 more
openalex   +1 more source

Preventing PTSD with oxytocin: effects of oxytocin administration on fear neurocircuitry and PTSD symptom development in recently trauma-exposed individuals

European Journal of Psychotraumatology, 2017
Background: Posttraumatic stress disorder (PTSD) is a debilitating psychiatric disorder which develops in approximately 10% of trauma-exposed individuals. Currently, there are few early preventive interventions available for PTSD.
Jessie L. Frijling
doaj   +1 more source

Intranasal administration of 40 and 80 units of insulin does not cause hypoglycemia during cardiac surgery: a randomized controlled trial [PDF]

, 2021
Patricia Roque, Yosuke Nakadate, Hiroaki Sato, Tamaki Sato, Linda Wykes, Akiko Kawakami, Hiroshi Yokomichi, Takashi Matsukawa, Thomas Schricker   +8 more
openalex   +1 more source

Targeting glioblastoma via intranasal administration of Ff bacteriophages [PDF]

Frontiers in Microbiology, 2015
Bacteriophages (phages) are ubiquitous viruses that control the growth and diversity of bacteria. Although they have no tropism to mammalian cells, accumulated evidence suggests that phages are not neutral to the mammalian macro-host and can promote immunomodulatory and anti-tumorigenic activities. Here we demonstrate that Ff phages that do not display
Dor-On, Eyal, Solomon, Beka
openaire   +3 more sources

Adjuvants : an essential component of neisseria vaccines [PDF]

, 2009
Adjuvants may be classified into delivery systems and immune potentiator or modulator molecules based on their mechanism of action. Neisseria vaccines containing traditional adjuvants such as aluminium salts have existed for long time, but meningitis ...
Acevedo, R., Balbao, J., Cabrera, O., Cuello, M., del Campo, J., Ferro, Valerie A., Gonzales, E., Romeu, B., Zayas, C.   +8 more
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