Results 171 to 180 of about 96,176 (305)

5‐Methoxy‐N,N‐dimethyltryptamine (5‐MeO‐DMT) for alcohol use disorder: An open‐label, phase 2, proof‐of‐concept, clinical trial

Addiction, EarlyView.
Abstract Background and Aims Psychedelic drugs may help treat alcohol use disorder (AUD). This study evaluated BPL‐003, a novel intranasal powder formulation of 5‐methoxy‐N,N‐dimethyltryptamine (5‐MeO‐DMT) benzoate salt, in people with moderate–severe AUD enrolled in a standard of care, 10‐week programme of relapse‐prevention oriented Cognitive ...
John Marsden, Michael Kelleher, Fiona Dunbar, Anna O. Ermakova, Luke Mitcheson, Claire Roberts, James J. Rucker, Gemma Scott, Ivan Saeger, Francesca Small, Mathieu Seynaeve   +10 more
wiley   +1 more source

A Single-Molecule Pleuripotent Scaffold for Combinational Therapy of Alzheimer's Disease via Intranasal Administration. [PDF]

Adv Sci (Weinh)
Gao JM, Li WB, Chen NN, Yi Y, Wang ZH, Chen X, Zhao YY, Yuan ZL, Gao J, Pan YC, Guo DS, Gong QH.   +11 more
europepmc   +1 more source

“Super‐Responders” to Dupilumab Treatment in Patients With Primary Diffuse Chronic Rhinosinusitis With Nasal Polyps

Allergy, EarlyView.
This study aimed to evaluate the feasibility of extending dupilumab dosing intervals in T2‐CRSwNP by assessing how many patients maintain disease control with once‐every‐12‐weeks (Q12W) dosing and comparing clinical characteristics of super‐responders and excellent responders. Tapering of dupilumab to Q12W appears feasible in super‐responding patients.
P. E. Vonk, J. J. Otten, H. B. E. Elzinga, R. J. L. van der Lans, G. F. J. P. Adriaensen, L. B. L. Benoist, D. R. Hoven, W. J. Fokkens, S. Reitsma, PolyREG Consortium, A.B. Rinia, I. Krebbers, I.J. Kleiss, M. E. Cornet   +13 more
wiley   +1 more source

Intranasal administration of broad-spectrum macrocyclic peptide inhibitor protects against SARS-CoV-2 Omicron variants. [PDF]

Nat Commun
Wang M, Yang J, Tan Y, Yuan S, Shi G, Peng Q, Li Y, Poon VK, Chan CC, Xiao N, Zhang AJ, Xie Y, Li J, Luo H, Fu Y, Chen Y, Compton AA, Zhang Y, Yang Y, Gao GF, Hou H, Chan JF, Yin Y, Shi Y.   +23 more
europepmc   +1 more source

Intranasal Administration of Mammary Tumour Milk Factor [PDF]

British Journal of Cancer, 1949
openaire   +2 more sources

Brain Delivery Strategies for Biomacromolecular Drugs: Intranasal Administration. [PDF]

Int J Nanomedicine
Wu H, Li C, Yuan H, Zhao J, Li S.
europepmc   +1 more source

Five‐Grass‐Pollen Sublingual Immunotherapy Drops Are Efficacious and Well Tolerated in Adults: The RHAPSODY Phase III Trial

Allergy, EarlyView.
The RHAPSODY multinational study investigated 26 months of continuous treatment with 5‐grass‐pollen sublingual SLIT drops in adults with moderate‐to‐severe grass‐pollen‐induced allergic rhinoconjunctivitis. The primary efficacy endpoint (the average daily total combined score) showed statistically significant differences in favour of the active ...
Alain Didier, Ruta Gronskyte Juhl, Terrie Dalgaard, Antoine Chartier, Philippe Devillier   +4 more
wiley   +1 more source

Oral and Intranasal Administration of Polydeoxyribonucleotide Isolated from <i>Porphyra</i> sp. Ameliorates Acute Lung Injury via Suppressing Proinflammatory Cytokine Production in Mice. [PDF]

Curr Issues Mol Biol
Lee GY, Lee WS, Han J, Yoo YC.
europepmc   +1 more source

Interstitial granulomatous drug reaction after intranasal desmopressin administration

Indian Journal of Dermatology, 2016
Maione, Vincenzo, STINCO, Giuseppe, Orsaria, Maria, Errichetti, Ezio   +3 more
openaire   +2 more sources

Allergic Sensitization to Inhalant Allergens in the Upper Respiratory Tract—the B Cell Side

Allergy, EarlyView.
ABSTRACT Allergic diseases are on the rise worldwide, driven by respiratory epithelial barrier dysfunction that promotes sensitization to inhalant allergens such as pollen, dust mites, pet dander, and fungal spores. These antigens trigger IgE‐mediated immune responses that lead to diseases such as allergic rhinitis (AR) and asthma.
Ola Grimsholm, Mohammed Zghaebi, Bita Hambrecht, Tanja Kalic, Christopher C. Udoye, Rudolf Manz, Barbara Bohle, Katarzyna M. Sitnik, Julia Eckl‐Dorna, Heimo Breiteneder   +9 more
wiley   +1 more source