Results 181 to 190 of about 1,950,206 (296)

Surgical Success in Obstructive Sleep Apnea Patients Using Preoperative Drug‐Induced Sleep Endoscopy and Awake Endoscopy Considering Disease Severity

World Journal of Otorhinolaryngology - Head and Neck Surgery, EarlyView.
ABSTRACT Background Obstructive sleep apnea (OSA) is a prevalent disorder characterized by recurrent episodes of airway obstruction during sleep, leading to fragmented sleep and oxygen desaturation. Identifying the precise site and pattern of obstruction is essential for surgical success. Awake endoscopy with Müller's maneuver (AEMM) has long been used,
Nafil Arimbrathodi, Arif Nambillath, Noora Alhail, Labiba Abughazzah, Waheed Rahman, Abhishek Menon, Yousef Hudaib, Majid Alabdulla   +7 more
wiley   +1 more source

Development of Propofol-Encapsulated Liposomes and the Effect of Intranasal Administration on Bioavailability in Rabbits. [PDF]

Pharmaceutics
Ujita H, Higuchi H, Nishioka Y, Miyake S, Sato R, Miyawaki T.   +5 more
europepmc   +1 more source

Hormone Replacement Therapy Uptake and Discontinuation Trends From 1996‐2023: An Observational Study of the Welsh Population

BJOG: An International Journal of Obstetrics &Gynaecology, EarlyView.
ABSTRACT Objective To analyse prescribing trends for oral and transdermal hormone replacement therapy (HRT) in Wales from 1996 to 2023, including predictors of discontinuation within one year of initiation. Design Observational study using the Secure Anonymised Information Linkage (SAIL) databank.
Robin Andrews, Arron Lacey, Kate Bache, Emma J. Kidd   +3 more
wiley   +1 more source

Progress, critical challenges, and translational prospects of intranasal administration of botanical essential oils for the treatment of depression. [PDF]

Front Pharmacol
Cheng K, Zhao H, He K, Xia X, Wang Y, Wang S, Li W.   +6 more
europepmc   +1 more source

5‐Methoxy‐N,N‐dimethyltryptamine (5‐MeO‐DMT) for alcohol use disorder: An open‐label, phase 2, proof‐of‐concept, clinical trial

Addiction, EarlyView.
Abstract Background and Aims Psychedelic drugs may help treat alcohol use disorder (AUD). This study evaluated BPL‐003, a novel intranasal powder formulation of 5‐methoxy‐N,N‐dimethyltryptamine (5‐MeO‐DMT) benzoate salt, in people with moderate–severe AUD enrolled in a standard of care, 10‐week programme of relapse‐prevention oriented Cognitive ...
John Marsden, Michael Kelleher, Fiona Dunbar, Anna O. Ermakova, Luke Mitcheson, Claire Roberts, James J. Rucker, Gemma Scott, Ivan Saeger, Francesca Small, Mathieu Seynaeve   +10 more
wiley   +1 more source

Psychological change processes in alcohol use disorder: A qualitative study of 5‐methoxy‐N,N‐dimethyltryptamine (5‐MeO‐DMT) with cognitive behavioural therapy

Addiction, EarlyView.
Abstract Background and aims This study qualitatively explored psychological change processes as described by participants and therapists within a phase 2a clinical trial evaluating the safety, tolerability, and preliminary efficacy of a single dose of intranasal 5‐methoxy‐N,N‐dimethyltryptamine (5‐MeO‐DMT; BPL‐003) administered alongside psychological
Mathieu Seynaeve, Fiona Dunbar, Anna O. Ermakova, Luke Mitcheson, James J. Rucker, Anthony Cleare, John Marsden   +6 more
wiley   +1 more source

A novel bispecific nanobody protects mice against RSV infection via intranasal administration. [PDF]

J Virol
Zhang M, Qin L, Guo R, Li J, Huang S, Sheng C, Xiang Y.   +6 more
europepmc   +1 more source

A framework to determine naloxone saturation with simulation modeling and cost‐effectiveness methods

Addiction, EarlyView.
Abstract Background and aims Jurisdictions lack practical tools to determine data‐informed naloxone saturation targets that account for local overdose dynamics and resource constraints. We aimed to introduce a generalizable framework that integrates simulation modeling with cost‐effectiveness principles to identify local naloxone saturation targets ...
Zongbo Li, Leah C. Shaw, Carolyn J. Park, Alexander Y. Walley, Czarina N. Behrends, Bruce R. Schackman, Brandon D. L. Marshall, Xiao Zang   +7 more
wiley   +1 more source

A Single-Molecule Pleuripotent Scaffold for Combinational Therapy of Alzheimer's Disease via Intranasal Administration. [PDF]

Adv Sci (Weinh)
Gao JM, Li WB, Chen NN, Yi Y, Wang ZH, Chen X, Zhao YY, Yuan ZL, Gao J, Pan YC, Guo DS, Gong QH.   +11 more
europepmc   +1 more source

Brain Delivery Strategies for Biomacromolecular Drugs: Intranasal Administration. [PDF]

Int J Nanomedicine
Wu H, Li C, Yuan H, Zhao J, Li S.
europepmc   +1 more source