Pharmaceutics, 2023 Intranasal administration is a promising strategy to enhance the delivery of the sEVsomes-based drug delivery system to the central nervous system (CNS).
Weiwei Shen +5 more
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A novel PKC activating molecule promotes neuroblast differentiation and delivery of newborn neurons in brain injuries [PDF]
, 2020 Neural stem cells are activated within neurogenic niches in response to brain injuries. This results in the production of neuroblasts, which unsuccessfully attempt to migrate toward the damaged tissue. Injuries constitute a gliogenic/non-neurogenic niche
A Buffo +48 more
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Effects of Topical Intranasal Doxycycline Treatment in the Rat Allergic Rhinitis Model [PDF]
Clinical and Experimental Otorhinolaryngology, 2014 ObjectivesAllergic rhinitis (AR) is a chronic upper respiratory tract disease that inflames the mucous membranes of the nose and occurs when circulating inflammatory cells including eosinophils and basophils migrate to and accumulate in the inflammation ...
Mehmet Ozgür Avincsal +4 more
doaj +1 more source
Nasal Drug Delivery Systems: An Overview [PDF]
, 2015 Since ancient times, drugs have been administered via the nasal route for therapeutic and recreational purposes. The interest in, and importance, of the systemic effects of drugs administered through the nasal route, have expanded over recent decades ...
Conway, Barbara R. +3 more
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Intranasal Drug Administration in Alzheimer-Type Dementia: Towards Clinical Applications
Pharmaceutics, 2023 Alzheimer-type dementia (ATD) treatments face limitations in crossing the blood–brain barrier and systemic adverse effects. Intranasal administration offers a direct route to the brain via the nasal cavity’s olfactory and trigeminal pathways.
Raquel Taléns-Visconti +4 more
doaj +1 more source
Oxytocin and social pretreatment have similar effects on processing of negative emotional faces in healthy adult males [PDF]
, 2013 Oxytocin has been shown to affect several aspects of human social cognition, including facial emotion processing. There is also evidence that social stimuli (such as eye-contact) can effectively modulate endogenous oxytocin levels.
Hernádi, Anna +3 more
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Журнал микробиологии, эпидемиологии и иммунобиологии, 2019 The aim of present research is studying of protective potency of candidate recombinant live pertussis vaccine (RLPV) for intranasal administration.Materials and methods.
L. N. Sinyashina +4 more
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A new subunit vaccine based on nucleoprotein nanoparticles confers partial clinical and virological protection in calves against bovine respiratory syncytial virus [PDF]
, 2010 Human and bovine respiratory syncytial viruses (HRSV and BRSV) are two closely related, worldwide prevalent viruses that are the leading cause of severe airway disease in children and calves, respectively.
Bernadet, Philippe +14 more
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A multicenter, open-label, long-term safety and tolerability study of DFN-02, an intranasal spray of sumatriptan 10 mg plus permeation enhancer DDM, for the acute treatment of episodic migraine. [PDF]
, 2017 BackgroundDFN-02 is a novel intranasal spray formulation composed of sumatriptan 10 mg and a permeation-enhancing excipient comprised of 0.2% 1-O-n-Dodecyl-β-D-Maltopyranoside (DDM).
Allenby, Kent +5 more
core +1 more source
Scientific Reports, 2022 The calcitonin gene-related peptide (CGRP) suppresses fear memory retention in mice. Although intracerebroventricular administration of CGRP alters the fear memory processes, making it a promising therapeutic strategy for post-traumatic stress disorder ...
Narumi Hashikawa-Hobara +3 more
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