Results 21 to 30 of about 65,548 (298)

Enhanced Bioavailability of Tadalafil after Intranasal Administration in Beagle Dogs

Pharmaceutics, 2018
Tadalafil is an oral selective phosphodiesterase type-5 inhibitor with demonstrated efficacy and safety that is used to treat erectile dysfunction. The purpose of this study is to compare the pharmacokinetic properties of tadalafil after conventional ...
Jeong-Soo Kim, Min-Soo Kim, In-hwan Baek
doaj   +2 more sources

Clinical and pharmacokinetics overview of intranasal administration of fentanyl. [PDF]

Heliyon, 2023
Due to the presence of large surfaces and high blood supply, drug delivery through the nasal route of administration is the appropriate route to administrate drugs with rapid onsets of action. Bypassing first-pass metabolism can increase drug bioavailability.
Nakhaee S, Saeedi F, Mehrpour O.
europepmc   +4 more sources

Utility of a Novel Micro-Spraying Device for Intranasal Administration of Drug Solutions to Mice

Pharmaceutics, 2023
Intranasal administration has attracted attention as a means of delivering drugs because it bypasses the blood–brain barrier. However, conventional intranasal administration of drug solutions to mice using the micropipette method (MP method) is ...
Naoto Suzuki, Hiroaki Tanigawa, Taiki Nagatomo, Hiroko Miyagishi, Takanori Kanazawa, Toyofumi Suzuki, Yasuhiro Kosuge   +6 more
doaj   +1 more source

Intranasal Administration of Drugs [PDF]

Archives of Otolaryngology–Head & Neck Surgery, 2008
To investigate how nasally applied substances distribute in the nose depending on the form of application.Observer-blinded study.University hospital research unit.Fifteen healthy volunteers aged 22 to 32 years.Forms of application included (1) nasal drops applied with a pipette, (2) nasal spray, and (3) a system producing squirts.
Mandy, Scheibe, Christopher, Bethge, Martin, Witt, Thomas, Hummel   +3 more
openaire   +2 more sources

Pharmacokinetic Characterisation and Comparison of Bioavailability of Intranasal Fentanyl, Transmucosal, and Intravenous Administration through a Three-Way Crossover Study in 24 Healthy Volunteers

Pain Research and Management, 2021
Background. For more than 60 years, the synthetic opioid fentanyl has been widely used in anaesthesia and analgesia. While the intravenous formulation is primarily used for general anaesthesia and intensive care settings, the drug’s high lipophilic ...
S. Nardi-Hiebl, J. W. Ndieyira, Y. Al Enzi, W. Al Akkad, T. Koch, G. Geldner, C. Reyher, L. H. J. Eberhart   +7 more
doaj   +1 more source

Intranasal administration of collagenase develops cerebral microbleeds and vascular dementia in mice: In vivo pilot study

Brain Hemorrhages, 2023
Objective: To establish a new animal model of lobar cerebral microbleeds (CMBs), we examined whether intranasal administration of collagenase induced CMBs in young mice which did not have hypertensive pathologic features. Methods: We used thirty-two male
Kenyu Hayashi, Prativa Sherchan, John H. Zhang, Yu Hasegawa   +3 more
doaj   +1 more source

Intranasal Vaccination With Recombinant Antigen-FLIPr Fusion Protein Alone Induces Long-Lasting Systemic Antibody Responses and Broad T Cell Responses

Frontiers in Immunology, 2021
A simple formulation is urgently needed for mucosal vaccine development. We employed formyl peptide receptor-like 1 inhibitory protein (FLIPr), an FcγR antagonist secreted by Staphylococcus aureus, as a vector to target ovalbumin (OVA) to dendritic cells
Ming-Shu Hsieh, Chia-Wei Hsu, Ling-Ling Tu, Kit Man Chai, Li-Lu Yu, Chiao-Chieh Wu, Mei-Yu Chen, Chen-Yi Chiang, Shih-Jen Liu, Shih-Jen Liu, Shih-Jen Liu, Ching-Len Liao, Hsin-Wei Chen, Hsin-Wei Chen, Hsin-Wei Chen   +14 more
doaj   +1 more source

Intranasal Administration of N-acetyl-L-cysteine Combined with Cell-Penetrating Peptide-Modified Polymer Nanomicelles as a Potential Therapeutic Approach for Amyotrophic Lateral Sclerosis

Pharmaceutics, 2022
Intranasal administration is a promising route for direct drug delivery to the brain; its combination with nanocarriers enhances delivery. We have previously shown that intranasal administration combined with PEG-PCL-Tat (a nanocarrier) efficiently ...
Takumi Kurano, Takanori Kanazawa, Shingo Iioka, Hiromu Kondo, Yasuhiro Kosuge, Toyofumi Suzuki   +5 more
doaj   +1 more source

Intranasal administration of acetylcholinesterase inhibitors [PDF]

BMC Neuroscience, 2008
This short review outlines the rationale, challenges, and opportunities for intranasal acetylcholinesterases, in particular galantamine. An in vitro screening model facilitated the development of a therapeutically viable formulation. In vivo testing confirmed achievement of therapeutically relevant drug levels that matched or exceeded those for oral ...
Costantino, Henry R, Leonard, Alexis, Brandt, Gordon, Johnson, Paul H, Quay, Steven C   +4 more
openaire   +2 more sources

Intranasal administration of regulatory dendritic cells is useful for the induction of nasal mucosal tolerance in a mice model of allergic rhinitis

World Allergy Organization Journal, 2020
Background: Intranasally administered dendritic cells (DCs) migrate into blood and thymus to induce immune responses. Regulatory dendritic cells (DCs) are also useful agents for allergy control.
Motohiko Suzuki, Makoto Yokota, Yoshihiro Kanemitsu, Wei-Ping Min, Shinya Ozaki, Yoshihisa Nakamura   +5 more
doaj   +1 more source