Results 31 to 40 of about 1,950,206 (296)

Electrocardiogram Assessment in Chough (Pyrrhocorax pyrrhocorax) Following Intranasal Administration of Anesthetics [PDF]

Iranian Journal of Veterinary Surgery, 2017
Objective- The objective of the present study was to define electrocardiographic data following intranasal administration of diazepam, midazolam and xylazine with or without Ketamine in Chough.Design- To determine the heart effects of anesthetics in ...
Majid Taati, Abbas Raisi
doaj   +1 more source

Brain delivery of valproic acid via intranasal administration of nanostructured lipid carriers: in vivo pharmacodynamic studies using rat electroshock model [PDF]

, 2011
Sharareh Eskandari1, Jaleh Varshosaz1, Mohsen Minaiyan2, Majid Tabbakhian11Department of Pharmaceutics, 2Department of Pharmacology, School of Pharmacy and Isfahan Pharmaceutical Sciences Research Center, Isfahan University of Medical Sciences, Isfahan ...
Tabbakhian, Majid, Sharareh Eskandari, Mohsen Minaiyan, et al, Minaiyan, Mohsen, Varshosaz, Jaleh, Jaleh Varshosaz, Majid Tabbakhian, Eskandari, Sharareh   +8 more
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Study of embryotoxic effects of intranasally administred desloratadine on laboratory animals. [PDF]

Medičnì Perspektivi, 2017
The study was conducted to detect possible changes in embryogenesis and negative effects of third generation antihistamine – desloratadine – after intranasal administration of 1.3 mg/m3 and 13.0 mg/m3 of the substance to laboratory animals during their ...
Т. А. Alekhina, V. А. Turkina, О. І. Grushka   +2 more
doaj   +2 more sources

Pharmacometric Modeling of the Impact of Azelastine Nasal Spray on SARS-CoV-2 Viral Load and Related Symptoms in COVID-19 Patients

Pharmaceutics, 2022
The histamine-1 receptor antagonist azelastine was recently found to impact SARS-CoV-2 viral kinetics in a Phase 2 clinical trial (CARVIN). Thus, we investigated the relationship between intranasal azelastine administrations and viral load, as well as ...
Christiane Dings, Peter Meiser, Frank Holzer, Michael Flegel, Dominik Selzer, Eszter Nagy, Ralph Mösges, Jens Peter Klussmann, Thorsten Lehr   +8 more
doaj   +1 more source

The pharmacokinetics of intranasal droperidol in volunteers characterised via population modelling

SAGE Open Medicine, 2018
Background: Droperidol is used parenterally to treat nausea and vomiting, migraine and acute behavioural disturbance. Intranasal use is not reported for droperidol.
Isabelle Cooper, Cornelia B Landersdorfer, Ashley Gordon St John, Andis Graudins   +3 more
doaj   +1 more source

Development and evaluation of vinpocetine inclusion complex for brain targeting

Asian Journal of Pharmaceutical Sciences, 2015
The objective of this paper is to prepare vinpocetine (VIN) inclusion complex and evaluate its brain targeting effect after intranasal administration. In the present study, VIN inclusion complex was prepared in order to increase its solubility. Stability
Jiaojiao Ding, Jinfeng Li, Shirui Mao
doaj   +1 more source

Pharmacokinetic analysis of dantrolene in plasma and brain after oral and intranasal administration.

, 2020
A. The peak dantrolene plasma concentration (Cmax) occurred at 20 minutes after intranasal administration (5mg/kg) and at 50 minutes after oral administration (5mg/kg).
Yun Shi (172065), Huafeng Wei (333273), Shuchun Yu (782080), Yan Wang (15435), Qingcheng Meng (8561451), Ge Liang (578601), Jintao Wang (8051), Maryellen F. Eckenhoff (8561454)   +7 more
core   +1 more source

Nose-to-brain delivery of donepezil within a small dose improves bioavailability and efficacy for Alzheimer’s disease treatment

Asian Journal of Pharmaceutical Sciences
Oral administration of donepezil (Don) is the first-line medication for Alzheimer’s disease (AD); however, the dysphagia of elderly patients and severe gastrointestinal side effects substantially restrict administration compliance.
Gang Wang, Xuezhe Duan, Defang Ouyang, Jianping Zhou, Huaqing Zhang, Yang Ding   +5 more
doaj   +1 more source

Advances and Challenges in Intranasal Delivery of Antipsychotic Agents Targeting the Central Nervous System

Frontiers in Pharmacology, 2022
Treatment of central nervous system (CNS) disorders is challenging using conventional delivery strategies and routes of administration because of the presence of the blood–brain barrier (BBB). This BBB restricts the permeation of most of the therapeutics
Manisha Pandey, Neha Jain, Jovita Kanoujia, Zahid Hussain, Bapi Gorain   +4 more
doaj   +1 more source

Model comparing intranasal challenge and aerosol challenge at high doses.

, 2023
Intranasal challenge is associated with an increase in bacterial burden over time. The distribution of bacteria following intranasal challenge is associated with the upper respiratory tract compared to aerosol challenge which is associated with the lower
Casey Cunningham (15179960), F. Heath Damron (12057899), Spencer R. Dublin (16428477), Mariette Barbier (526468), Maria de la Paz Gutierrez (17327976), Gage M. Pyles (12057884), M. Allison Wolf (12057896), Matthew Warden (17327979), Annalisa B. Huckaby (12057890), Jesse M. Hall (7528685), William T. Witt (5868830), Kelly L. Weaver (12057878), Megan A. DeJong (12057893), Emel Sen-Kilic (5868818), Graham J. Bitzer (17327973), Jonathan E. Petty (17327982), Ting Y. Wong (5868815)   +16 more
core   +1 more source