Salivary Oxytocin Concentrations in Males following Intranasal Administration of Oxytocin: A Double-Blind, Cross-Over Study. [PDF]
PLoS ONE, 2015 The use of intranasal oxytocin (OT) in research has become increasingly important over the past decade. Although researchers have acknowledged a need for further investigation of the physiological effects of intranasal administration, few studies have ...
Katie Daughters +5 more
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Pharmacokinetics, absolute bioavailability and tolerability of ketamine after intranasal administration to dexmedetomidine sedated dogs. [PDF]
PLoS ONE, 2020 Intranasal ketamine has recently gained interest in human medicine, not only for its sedative, anaesthetic or analgesic properties, but also in the management of treatment resistant depression, where it has been shown to be an effective, fast acting ...
Lise Vlerick +6 more
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Pharmacokinetic Modeling of the “Nose-to-Brain” Pathway as Demonstrated by Intranasal Administration of Cannabidiol-Loaded Nanoparticles [PDF]
PharmaceuticalsBackground/Objectives: Cannabidiol is a non-psychoactive substance that possesses properties suitable for the treatment of several disorders related to the central nervous system.
Ilya Eydelman +2 more
doaj +2 more sources
Brain Research Bulletin, 2023 While skeletal muscle creatine levels can be enhanced by exogenous creatine supplementation, the elevation of brain creatine levels with oral creatine administration remains a challenge due to a lack of effective transportation of creatine through the ...
Kaiqing Chen, Xiaoping Hu
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Bioavailability of butorphanol after intranasal administration to horses. [PDF]
Bulgarian Journal of Veterinary Medicine, 2020 The aim of the present study was to describe butorphanol pharmacokinetics and bioavailability following intranasal administration to horses. Six adult horses received 0.05 mg/kg butorphanol, in a randomised crossover design, by either intravenous or ...
V. Ferreira +2 more
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Intranasal Drug Administration in Alzheimer-Type Dementia: Towards Clinical Applications
Pharmaceutics, 2023 Alzheimer-type dementia (ATD) treatments face limitations in crossing the blood–brain barrier and systemic adverse effects. Intranasal administration offers a direct route to the brain via the nasal cavity’s olfactory and trigeminal pathways.
Raquel Taléns-Visconti +4 more
doaj +3 more sources
Intranasal administration of dantrolene increased brain concentration and duration.
PLoS ONE, 2020 Dantrolene has been demonstrated to be neuroprotective for multiple neurodegenerative diseases. However, dantrolene's limited penetration into the CNS hampers its effectiveness as a neuroprotective agent.
Jintao Wang +7 more
doaj +2 more sources
Журнал микробиологии, эпидемиологии и иммунобиологии, 2019 The aim of present research is studying of protective potency of candidate recombinant live pertussis vaccine (RLPV) for intranasal administration.Materials and methods.
L. N. Sinyashina +4 more
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The Intranasal Administration of Semaphorin 3A Inhibitor in a Mouse Model of Olfactory Disorder. [PDF]
CureusThis study investigated the effects of intranasal administration of a semaphorin 3A inhibitor (Sema3A-I) in a mouse model of olfactory disorder, where olfactory sensory neuron (OSN) axons had been severely damaged.
Murai A +5 more
europepmc +2 more sources
Intranasal Administration of the Combination of Dextro-Ketamine and Dexmedetomidine for Treatment of Diabetic Neuropathic Pain in Rats. [PDF]
J Pain ResSusumu Zapata Sudo,1,* Tadeu Lima Montagnoli,2,* Bruno Eduardo Dematté,3 Aimeé Diogenes Santos,2 Margarete Manhães Trachez,4 Fernanda Gubert,5 Rosalia Mendez-Otero,6 Gisele Zapata-Sudo1– 5 1Programa de Pós-Graduação em Medicina (Cirurgia Geral ...
Sudo SZ +7 more
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