Results 11 to 20 of about 1,950,206 (296)
Intranasal Drug Administration in Alzheimer-Type Dementia: Towards Clinical Applications [PDF]
Pharmaceutics, 2023 Alzheimer-type dementia (ATD) treatments face limitations in crossing the blood–brain barrier and systemic adverse effects. Intranasal administration offers a direct route to the brain via the nasal cavity’s olfactory and trigeminal pathways.
Raquel Taléns-Visconti +4 more
doaj +2 more sources
Intranasal administration of dantrolene increased brain concentration and duration.
PLoS ONE, 2020 Dantrolene has been demonstrated to be neuroprotective for multiple neurodegenerative diseases. However, dantrolene's limited penetration into the CNS hampers its effectiveness as a neuroprotective agent.
Jintao Wang +7 more
doaj +2 more sources
Bioavailability of butorphanol after intranasal administration to horses. [PDF]
Bulgarian Journal of Veterinary Medicine, 2020 The aim of the present study was to describe butorphanol pharmacokinetics and bioavailability following intranasal administration to horses. Six adult horses received 0.05 mg/kg butorphanol, in a randomised crossover design, by either intravenous or ...
V. Ferreira +2 more
doaj +2 more sources
Brain delivery of vasoactive intestinal peptide (VIP) following nasal administration to rats [PDF]
, 2003 The aim of this work was to study in rats the nasal route for the brain delivery of the vasoactive intestinal peptide (VIP) neuropeptide. After evaluating VIP stability in solutions obtained from nasal washes, the effect of formulation parameters (pH 4-9,
Dufès, Christine +5 more
core +3 more sources
The Intranasal Administration of Semaphorin 3A Inhibitor in a Mouse Model of Olfactory Disorder. [PDF]
CureusThis study investigated the effects of intranasal administration of a semaphorin 3A inhibitor (Sema3A-I) in a mouse model of olfactory disorder, where olfactory sensory neuron (OSN) axons had been severely damaged.
Murai A +5 more
europepmc +2 more sources
World Allergy Organization Journal, 2020 Background: Intranasally administered dendritic cells (DCs) migrate into blood and thymus to induce immune responses. Regulatory dendritic cells (DCs) are also useful agents for allergy control.
Motohiko Suzuki +5 more
doaj +1 more source
Intranasal administration of acetylcholinesterase inhibitors [PDF]
BMC Neuroscience, 2008 This short review outlines the rationale, challenges, and opportunities for intranasal acetylcholinesterases, in particular galantamine. An in vitro screening model facilitated the development of a therapeutically viable formulation. In vivo testing confirmed achievement of therapeutically relevant drug levels that matched or exceeded those for oral ...
Costantino, Henry R +4 more
openaire +2 more sources
Current Therapeutic Research, 2014 Background: The gold standard for cobalamin deficiency treatment is administration of cobalamin by intramuscular injection. The injection is painful and inconvenient, particularly for elderly persons.
Monique P.H. Tillemans, PharmD +4 more
doaj +1 more source
Inhaled Insulin: Intrapulmonary or Intranasal? [PDF]
, 2012 Initial attempts delivered the insulin hormone intramuscularly, intravenously, and eventually subcutaneously. Other routes of administration of the drug were explored.
Shivangi Jaiswal +3 more
core +1 more source
Pharmacokinetics and tolerability of intranasal or intravenous administration of nalbuphine in infants [PDF]
, 2022 OBJECTIVES: Intranasal nalbuphine could be a safe, efficacious and non-invasive alternative to parenteral pain medication in infants. We aimed to assess pharmacokinetics (PK) and tolerability of intranasal and intravenous nalbuphine administration in ...
Pfiffner, Miriam +10 more
core +1 more source