Results 81 to 90 of about 2,191,985 (278)

Leaf-Encapsulated Vaccines: Agroinfiltration and Transient Expression of the Antigen Staphylococcal Endotoxin B in Radish Leaves. [PDF]

open access: yes, 2018
Transgene introgression is a major concern associated with transgenic plant-based vaccines. Agroinfiltration can be used to selectively transform nonreproductive organs and avoid introgression.
Gallo, Richard L   +6 more
core   +3 more sources

Perivascular and Perineural Pathways Involved in Brain Delivery and Distribution of Drugs after Intranasal Administration

open access: yesPharmaceutics, 2019
One of the most challenging aspects of treating disorders of the central nervous system (CNS) is the efficient delivery of drugs to their targets within the brain.
Jeffrey J. Lochhead, T. Davis
semanticscholar   +1 more source

The clinical pharmacology of intranasal l-methamphetamine. [PDF]

open access: yes, 2008
BackgroundWe studied the pharmacology of l-methamphetamine, the less abused isomer, when used as a nasal decongestant.Methods12 subjects self-administered l-methamphetamine from a nonprescription inhaler at the recommended dose (16 inhalations over 6 ...
Everhart, Tom   +6 more
core   +2 more sources

Intranasal fentanyl for pain control: current status with a focus on patient considerations

open access: yesPatient Preference and Adherence, 2011
Eric Prommer, Lisa ThompsonDivision of Hematology/Oncology, Mayo Clinic College of Medicine, Mayo Clinic Hospital, Scottsdale, AZ, USAAbstract: Of several newer delivery systems under development and investigation for the administration of opioids, the ...
Eric Prommer, Lisa Thompson
doaj  

Intranasal administration of gentamicin in human subjects [PDF]

open access: yesAntimicrobial Agents and Chemotherapy, 1983
The effectiveness of gentamicin administered by the intranasal route in healthy human volunteers was studied. Thirty minutes after gentamicin in a solution of 1% sodium glycocholate was administered at 2 mg/kg of body weight, gentamicin concentrations of 2.48 +/- 0.42 mg/ml were present in the sera. Serum concentrations decreased to 0.94 +/- 0.13 mg/ml
openaire   +2 more sources

Corticosteroids for the common cold [PDF]

open access: yes, 2015
BACKGROUND: The common cold is a frequent illness, which, although benign and self limiting, results in many consultations to primary care and considerable loss of school or work days. Current symptomatic treatments have limited benefit.
Del Mar, Chris B.   +5 more
core   +1 more source

Effects of Intranasal Orexin-A (Hypocretin-1) Administration on Neuronal Activation, Neurochemistry, and Attention in Aged Rats

open access: yesFrontiers in Aging Neuroscience, 2020
Cognitive function represents a key determinative factor for independent functioning among the elderly, especially among those with age-related cognitive disorders.
Coleman B. Calva   +2 more
doaj   +1 more source

Intranasal administration of exosomes derived from mesenchymal stem cells ameliorates autistic-like behaviors of BTBR mice

open access: yesMolecular Autism, 2018
Autism spectrum disorders (ASD) are neurodevelopmental disorders characterized by three core symptoms that include social interaction deficits, cognitive inflexibility, and communication disorders.
Nisim Perets   +3 more
semanticscholar   +1 more source

Bacterial outer membrane vesicles and vaccine applications [PDF]

open access: yes, 2014
Vaccines based on outer membrane vesicles (OMV) were developed more than 20 years ago against Neisseria meningitidis serogroup B. These nano-sized structures exhibit remarkable potential for immunomodulation of immune responses and delivery of “self ...
Acevedo, Reinaldo   +10 more
core   +2 more sources

Neonatal Genetic Delivery of Anti-Respiratory Syncytial Virus (RSV) Antibody by Non-Human Primate-Based Adenoviral Vector to Provide Protection against RSV

open access: yesVaccines, 2018
Respiratory syncytial virus (RSV) is one of the leading causes of lower respiratory tract infection in infants. Immunoprophylaxis with the anti-RSV monoclonal antibody, palivizumab, reduces the risk for RSV-related hospitalizations, but its use is ...
Rika Gomi   +3 more
doaj   +1 more source

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