Results 261 to 270 of about 57,277 (349)

Biomaterial Strategies for Targeted Intracellular Delivery to Phagocytes

Advanced Functional Materials, Volume 36, Issue 1, 2 January 2026.
Phagocytes are essential to a functional immune system, and their behavior defines disease outcomes. Engineered particles offer a strategic opportunity to target phagocytes, harnessing inflammatory modulation in disease. By tuning features like size, shape, and surface, these systems can modulate immune responses and improve targeted treatment for a ...
Kaitlyn E. Woodworth, Neal I. Callaghan, Locke Davenport Huyer   +2 more
wiley   +1 more source

Intranasal Delivery of Lithium Salt Suppresses Inflammatory Pyroptosis in the Brain and Ameliorates Memory Loss and Depression-like Behavior in 5XFAD Mice. [PDF]

J Neuroimmune Pharmacol
Bhuiyan P, Zhang W, Liang G, Jiang B, Vera R, Chae R, Kim K, Louis LS, Wang Y, Liu J, Chuang DM, Wei H.   +11 more
europepmc   +1 more source

Effects of intranasal drug delivery on the autonomic system in rehabilitation neurology

O. M. Stoyanov, R. S. Vastyanov, Э. М. Мирджураев, Anatoliy Son, G.O. Volokhova, V.I. Kalashnikov   +5 more
openalex   +2 more sources

Chitosan-Mangafodipir nanoparticles designed for intranasal delivery of siRNA and DNA to brain

, 2017
Juan Sanchez‐Ramos, Shijie Song, Xiaoyuan Kong, Parastou Foroutan, Gary V. Martinez, William Dominguez-Viqueria, Shyam S. Mohapatra, Subhra Mohapatra, Reka A. Haraszti, Anastasia Khvorova, Neil Aronin, Vasyl Sava   +11 more
openalex   +1 more source

Lithium‐Charged Gold Nanoparticles: A New Powerful Tool for Lithium Delivery and Modulation of Glycogen Synthase Kinase 3 Activity

Advanced Materials, Volume 38, Issue 3, 13 January 2026.
This study introduces glutathione‐stabilized gold nanoparticles for targeted lithium delivery (LiG‐AuNPs), enabling the controlled modulation of Glycogen Synthase Kinase‐3 (GSK‐3β). These non‐toxic, 2‐nm particles release lithium intracellularly, effectively inhibiting GSK‐3β in the brain without significant plasma lithium alterations.
Antonio Buonerba, Giulia Puliatti, Domenica Donatella Li Puma, Bruno Bandiera, Beatrice Cannata, Maria Elena Marcocci, Nicolina Castagno, Irene Contento, Salvatore Impemba, Mariarosa Scognamiglio, Rocco Di Girolamo, Vincenzo Naddeo, Patrizia Canton, Carmine Capacchione, Laura Sposito, Martina Albini, Francesco Pastore, Silvia Baroni, Alfonso Grassi, Claudio Grassi, Roberto Piacentini   +20 more
wiley   +1 more source

Intranasal Delivery of Brain-Derived Neurotrophic Factor (BDNF)-Loaded Small Extracellular Vesicles for Treating Acute Spinal Cord Injury in Rats and Monkeys. [PDF]

J Extracell Vesicles
Huang Z, Li J, Wo J, Li CL, Wu ZC, Deng XH, Liang Y, Li F, Chen B, Jia B, Wang L, Wang Y, Sun G, Li Z, Zhu H, Guest JD, So KF, Fu QL, Zhou L.   +18 more
europepmc   +1 more source

Evaluation of Antigen Expression and Early Immune Response Following Cutaneous Suction‐Mediated DNA Delivery

Advanced Therapeutics, Volume 9, Issue 1, January 2026.
In vivo suction‐based cutaneous DNA vaccination promotes robust immunogenic responses. The spatiotemporal patterns of antigen expression following suction‐based SARS‐CoV‐2 DNA vaccine delivery are evaluated in rat skin via immunofluorescence staining.
Nandita C. Jhumur, Yukyung Um, Sarah H. Park, Emran O. Lallow, Christine C. Roberts, Jerry W. Shan, Jonathan P. Singer, Jeffrey D. Zahn, Young K. Park, Lisa K. Denzin, David I. Shreiber, Joel N. Maslow, Hao Lin   +12 more
wiley   +1 more source

Intranasal Delivery of Medications for the Treatment of Neurologic Conditions: A Pharmacology Update. [PDF]

J Neurosci Nurs
Shafer PO, Dean P, Brooks L, Gidal B, Misra SN, Carrazana E.   +5 more
europepmc   +1 more source

Computational Design and Glycoengineering of Interferon‐Lambda for Nasal Prophylaxis Against Respiratory Viruses

Advanced Science, Volume 13, Issue 6, 30 January 2026.
This study presents an engineered human interferon‐lambda (hIFN‐λ) as an intranasal prophylactic against respiratory viruses. By combining AI‐guided backbone redesign and glycoengineering, the authors developed a thermostable, protease‐resistant, and scalable variant with improved mucosal penetration.
Jeongwon Yun, Seungju Yang, Jae Hyuk Kwon, Luiz Felipe Vecchietti, Ji Hyun Choi, Mi‐ra Choi, Keun Bon Ku, Hyun‐Joo Ro, Kyun‐Do Kim, Meeyoung Cha, Hyun Jung Chung, Ji Eun Oh, Ho Min Kim   +12 more
wiley   +1 more source