Results 271 to 280 of about 57,259 (320)
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Intranasal delivery: Physicochemical and therapeutic aspects
International Journal of Pharmaceutics, 2007Interest in intranasal (IN) administration as a non-invasive route for drug delivery continues to grow rapidly. The nasal mucosa offers numerous benefits as a target issue for drug delivery, such as a large surface area for delivery, rapid drug onset, potential for central nervous system delivery, and no first-pass metabolism.
Henry R, Costantino +4 more
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Intranasal delivery of biotechnology-based therapeutics
Drug Discovery Today, 2022Biotechnology-based therapeutics include a wide range of products, such as recombinant hormones, stem cells, therapeutic enzymes, monoclonal antibodies, genes, vaccines, among others. The administration of these macromolecules has been studied via various routes.
Dhrumi, Patel +2 more
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Clinical Research and Regulatory Affairs, 1993
AbstractThe intranasal administration of drugs is a promising alternative to parenteral administration. The nasal route represents an interesting alternative for drugs which have low oral bioavailability because of degradation in GI tract or extensive mucosal or first-pass metabolism.
H. Zia, P. Dondeti, T. E. Needham
openaire +1 more source
AbstractThe intranasal administration of drugs is a promising alternative to parenteral administration. The nasal route represents an interesting alternative for drugs which have low oral bioavailability because of degradation in GI tract or extensive mucosal or first-pass metabolism.
H. Zia, P. Dondeti, T. E. Needham
openaire +1 more source
Intranasal delivery of antipsychotic drugs
Schizophrenia Research, 2017Antipsychotic drugs are used to treat psychotic disorders that afflict millions globally and cause tremendous emotional, economic and healthcare burdens. However, the potential of intranasal delivery to improve brain-specific targeting remains unrealized. In this article, we review the mechanisms and methods used for brain targeting via the intranasal (
Yogesh K. Katare +7 more
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Biomaterials for intranasal and inhaled vaccine delivery
Nature Reviews Bioengineering, 2023Delivery of vaccines by nasal sprays may enable more robust, protective mucosal immune responses against infectious diseases, such as COVID-19, compared with intramuscular injection. In this Comment, we highlight how biomaterials can be designed to allow intranasal and inhaled vaccination.
Devorah Cahn +3 more
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Intranasal Delivery of Neuropeptides
2011A major barrier to entry of neuropeptides into the brain is low bioavailability and presence of the blood-brain barrier. Intranasal delivery of neuropeptides provides a potentially promising alternative to other routes of administration, since a direct pathway exists between the olfactory neuroepithelium and the brain. Use of the rat as an animal model
Michael C, Veronesi +2 more
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Intranasal Drug Delivery for Brain Targeting
Current Drug Delivery, 2005Many drugs are not being effectively and efficiently delivered using conventional drug delivery approach to brain or central nervous system (CNS) due to its complexity. The brain and the central nervous system both have limited accessibility to blood compartment due to a number of barriers.
Tushar K, Vyas +3 more
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Advanced Drug Delivery Reviews, 1998
In recent years the nasal route has received a great deal of attention as a convenient and reliable method for the systemic administration of drugs. Although this route is currently being marketed for the systemic administration of several drugs, it has only recently been studied.
openaire +2 more sources
In recent years the nasal route has received a great deal of attention as a convenient and reliable method for the systemic administration of drugs. Although this route is currently being marketed for the systemic administration of several drugs, it has only recently been studied.
openaire +2 more sources