Results 271 to 280 of about 57,277 (349)

Patient with recurrent grade 4 astrocytoma responding favorably to intranasal delivery of NEO100, highly pure perillyl alcohol: illustrative case. [PDF]

J Neurosurg Case Lessons
Schönthal AH, Swenson S, Senecal FM, Mittenzwei R, Go JL, Chen TC.   +5 more
europepmc   +1 more source

PBLD Orchestrates the STING‐Mediated Antiviral Immune Response and Autoimmune Diseases

Advanced Science, Volume 13, Issue 4, 19 January 2026.
During viral infection, PBLD expression is downregulated, thereby subverting host antiviral defenses and promoting viral replication. This study identifies PBLD as a positive regulator of STING‐induced type I interferon activation and delineated the molecular network underlying PBLD‐mediated antiviral immunity and autoimmune pathogenesis, highlighting ...
Peili Hou, Hongchao Zhu, Xiaonan Sun, Ni Zhang, Song Wang, Xuexing Zheng, Xiaoyun Wang, Yueyue Feng, Fuzhen Zhang, Xingyu Li, Rui Li, Xiaomeng Wang, Yuanyuan Han, Jun Wang, Chuanhong Wang, Xiaoyang Yao, Hongmei Wang, Hongbin He   +17 more
wiley   +1 more source

Light Metabolically Reprograms CD8+ T Cells to Potentiate STING‐Driven Tumor Eradication and Prevent Metastasis

Advanced Science, Volume 13, Issue 1, 5 January 2026.
Low‐level light (LLL) rejuvenates exhausted CD8+ T cells, boosting STING‐driven tumor eradication and prevents metastasis. NanoSTING@Mn enhances CD8+ T cells infiltration while LLL restores its function expanding to progenitor‐exhausted cells. These cells form central memory T cells in lymphoid organs. Intranasal nanoSTING@Mn redirects antitumor CD8+ T
Asmita Banstola, Shilin Gao, Zhengkung Zhang, Yan Dong, Prabhat Upadhyay, Quanwei Zhang, Yongli Li, Zuan‐Tao Lin, Zhilong Wang, Mei X. Wu   +9 more
wiley   +1 more source

Nose to Brain: Exploring the Progress of Intranasal Delivery of Solid Lipid Nanoparticles and Nanostructured Lipid Carriers. [PDF]

Int J Nanomedicine
Zheng Y, Cui L, Lu H, Liu Z, Zhai Z, Wang H, Shao L, Lu Z, Song X, Zhang Y.   +9 more
europepmc   +1 more source

Brain‐peripheral proteome crosstalk in Alzheimer's disease with and without diabetes mellitus

Alzheimer's &Dementia, Volume 22, Issue 1, January 2026.
Abstract BACKGROUND Although considerable research has investigated diabetes mellitus (DM) as a risk factor for Alzheimer's disease (AD) dementia, the mechanistic understanding of the associations between peripheral and central biological processes in AD and AD within DM remains limited.
Anat Yaskolka Meir, Xingyan Wang, Shinya Tasaki, Vishal Sarsani, Aron S. Buchman, Steven E. Arnold, David A. Bennett, Vladislav A. Petyuk, Liming Liang, Ana W. Capuano, Zoe Arvanitakis   +10 more
wiley   +1 more source

A cognitive screening program in community‐based medical clinics to facilitate Latino participation in Alzheimer's disease research

Alzheimer's &Dementia, Volume 22, Issue 1, January 2026.
Abstract INTRODUCTION Relatively low rates of Latino participation in Alzheimer's disease and related dementias (ADRD) research makes it difficult to determine whether identified disease mechanisms, risk factors, or novel treatments generalize to this population.
David P. Salmon, Caytre Ede, Christina Gigliotti, Emily A. Little, Melanie L. Quiring, Roberto Gratianne, Jairo A. Romero, Diane M. Jacobs, Guerry M. Peavy, Douglas Galasko   +9 more
wiley   +1 more source

Brain-targeted intranasal delivery of protein-based gene therapy for treatment of ischemic stroke. [PDF]

Theranostics
Ryu JY, Cerecedo-Lopez C, Yang H, Ryu I, Du R.   +4 more
europepmc   +1 more source

Almond oil-loaded liposomal nanocarriers for intranasal delivery in Alzheimer’s disease: Formulation, characterization, and pharmacological evaluation

Shweta Swagatika Bhanja, Shyamalendu Tripathy, Abhishek Mishra, Biswabhusan Biswal, Dinesh Kumar Sharma   +4 more
openalex   +1 more source

The impact of volunteering on cognition and cognitive decline in older diverse cohorts: KHANDLE and STAR

Alzheimer's &Dementia, Volume 22, Issue 1, January 2026.
Abstract INTRODUCTION Volunteering is linked to cognitive benefits in aging, but evidence in diverse populations is limited. METHODS We examined volunteering and cognition in Kaiser Healthy Aging and Diverse Life Experiences Study/Study of Healthy Aging in African Americans participants (N = 2789) with unimpaired cognition at baseline. Volunteering and
Yi Lor, Hilary Colbeth, Marianne Chanti‐Ketterl, Emily Hokett, Evan Fletcher, Zvinka Z. Zlatar, Nancy X. Chen, Nirmalbhai Tandel, Paola Gilsanz, Elizabeth Rose Mayeda, Rachel A. Whitmer   +10 more
wiley   +1 more source

Intranasal delivery of engineered extracellular vesicles loaded with miR-206-3p antagomir ameliorates Alzheimer's disease phenotypes. [PDF]

Theranostics
Peng D, Liu T, Lu H, Zhang L, Chen H, Huang Y, Hu B, Zhang Q.   +7 more
europepmc   +1 more source