Results 301 to 310 of about 57,277 (349)
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Intranasal delivery of antipsychotic drugs
Schizophrenia Research, 2017Antipsychotic drugs are used to treat psychotic disorders that afflict millions globally and cause tremendous emotional, economic and healthcare burdens. However, the potential of intranasal delivery to improve brain-specific targeting remains unrealized. In this article, we review the mechanisms and methods used for brain targeting via the intranasal (
Yogesh K. Katare +7 more
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Biomaterials for intranasal and inhaled vaccine delivery
Nature Reviews Bioengineering, 2023Delivery of vaccines by nasal sprays may enable more robust, protective mucosal immune responses against infectious diseases, such as COVID-19, compared with intramuscular injection. In this Comment, we highlight how biomaterials can be designed to allow intranasal and inhaled vaccination.
Devorah Cahn +3 more
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Intranasal Delivery of Neuropeptides
2011A major barrier to entry of neuropeptides into the brain is low bioavailability and presence of the blood-brain barrier. Intranasal delivery of neuropeptides provides a potentially promising alternative to other routes of administration, since a direct pathway exists between the olfactory neuroepithelium and the brain. Use of the rat as an animal model
Michael C, Veronesi +2 more
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Intranasal Drug Delivery for Brain Targeting
Current Drug Delivery, 2005Many drugs are not being effectively and efficiently delivered using conventional drug delivery approach to brain or central nervous system (CNS) due to its complexity. The brain and the central nervous system both have limited accessibility to blood compartment due to a number of barriers.
Tushar K, Vyas +3 more
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Intranasal delivery: Physicochemical and therapeutic aspects
International Journal of Pharmaceutics, 2007Interest in intranasal (IN) administration as a non-invasive route for drug delivery continues to grow rapidly. The nasal mucosa offers numerous benefits as a target issue for drug delivery, such as a large surface area for delivery, rapid drug onset, potential for central nervous system delivery, and no first-pass metabolism.
Henry R, Costantino +4 more
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Advanced Drug Delivery Reviews, 1998
In recent years the nasal route has received a great deal of attention as a convenient and reliable method for the systemic administration of drugs. Although this route is currently being marketed for the systemic administration of several drugs, it has only recently been studied.
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In recent years the nasal route has received a great deal of attention as a convenient and reliable method for the systemic administration of drugs. Although this route is currently being marketed for the systemic administration of several drugs, it has only recently been studied.
openaire +2 more sources
Intranasal Delivery of Nanoparticle-Based Vaccines
Therapeutic Delivery, 2017Most pathogens gain access to the human body and initiate systemic infections through mucosal sites. A large number of currently marketed licensed vaccines are parenterally administered; they generate strong systemic immunity but not mucosal immunity.
Marasini, Nirmal +2 more
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Intranasal delivery of tenoxicam in rat
International Journal of Pharmaceutics, 2001Intranasal delivery of tenoxicam was studied in male rats on single dose administration of 0.36 mg/rat and compared with intravenous administration. Tenoxicam plasma levels were determined by RP-HPLC method with UV detection that employed piroxicam as an electroactive internal standard in the analysis.
C V, Raghavan, V D, Abimon
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Focused ultrasound mediated intranasal delivery
The Journal of the Acoustical Society of America, 2021This presentation will introduce that focused ultrasound combined with intranasal delivery can achieve locally enhanced delivery of anti-programmed cell death-ligand 1 antibody to an intracranial murine glioma model.
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Intranasal delivery of vaccines against HIV
Expert Opinion on Drug Delivery, 2006HIV poses a serious health threat in the world. Mucosal transmission of HIV through the genitourinary tract may be the most important route of transmission. Intranasal immunisations induce vaginal and systemic immune responses. Various protein-, DNA- and RNA-based immunopotentiating adjuvants/delivery systems and live bacterial and viral vectors are ...
Michael, Vajdy, Manmohan, Singh
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