Results 141 to 150 of about 158,913 (343)
Intratumoral Nerve Phased Development: A Promising Therapeutic Target
Medicine Bulletin, EarlyView.ABSTRACT The nervous system has emerged as a critical regulator of tumor biology, engaging in dynamic crosstalk with cancer cells. Although the protumorigenic role of innervation is well established, increasing attention is now directed toward reciprocal influences—how tumors actively shape and remodel local nerve networks within the tumor ...
Xiangxian Che +3 more
wiley +1 more source
Therapeutic decision making in autoimmune and inflammatory disorders of the central nervous system in children. [PDF]
, 2016 Autoimmune and inflammatory disorders of the central nervous system can result in significant morbidity and mortality. Through the recognition of syndromes using diagnostic biomarkers, the clinician is now able to use immune suppressive therapies to ...
Dale, Rc, Lim, M., Nosadini, M
core
Intrathecal IgG Synthesis: A Resistant and Valuable Target for Future Multiple Sclerosis Treatments
Multiple Sclerosis International, 2015 Intrathecal IgG synthesis is a key biological feature of multiple sclerosis (MS). When acquired early, it persists over time. A growing body of evidence suggests that intrathecal Ig-secreting cells may be pathogenic either by a direct action of toxic IgG
M. Bonnan
semanticscholar +1 more source
Exploring Autophagy Inducing Molecules: Targeting Diverse Pathways in Alzheimer's Disease Management
Medicinal Research Reviews, EarlyView.ABSTRACT Neurodegenerative disorders, including Alzheimer's disease (AD), impose a significant burden on society due to their progressive nature and the associated healthcare costs. Autophagy, a vital cellular degradation process, has emerged as a promising therapeutic target in these disorders.
Baljinder Singh +4 more
wiley +1 more source
Intrathecal drug delivery in the era of nanomedicine.
Advanced Drug Delivery Reviews, 2020 M. Fowler +6 more
semanticscholar +1 more source
Neurourology and Urodynamics, EarlyView.ABSTRACT Aims While many patients with lower urinary tract symptoms (LUTS) improve by treating peripheral causes, a substantial proportion continue to experience symptoms despite apparently successful interventions. Central nervous system (CNS) mechanisms could potentially contribute to persisting symptoms after the initial peripheral cause has been ...
Mathijs M. de Rijk +7 more
wiley +1 more source
Evaluation of Treatment Outcomes of High‐Risk Gestational Trophoblastic Neoplasms (GTNs)
Natural Sciences, EarlyView.ABSTRACT This study was performed to assess the efficacy, safety, and prognostic factors of treatment protocols in patients with high‐risk gestational trophoblastic neoplasia (GTN). Data of 64 high‐risk GTN patients treated at our clinic between January 1993 and December 2020 were retrospectively analyzed. Patients were classified according to the FIGO
Ayberk Çakır +3 more
wiley +1 more source
Pediatric Blood &Cancer, EarlyView.ABSTRACT Purpose Children with B‐acute lymphoblastic leukemia (B‐ALL) treated in resource‐intensive settings have a high likelihood of cure, but therapy is long, burdensome, and associated with substantial toxicities. Understanding parents’ perceptions of the most disruptive and difficult aspects of B‐ALL treatment is critical to future improvements in
Kellee N. Parker +7 more
wiley +1 more source
Pediatric Blood &Cancer, EarlyView.ABSTRACT Background Methotrexate‐associated leukoencephalopathy is poorly documented in osteosarcoma. Since 2007, our institution has monitored osteosarcoma patients with sequential magnetic resonance imaging (MRI) and neuropsychological evaluations during treatment and follow‐up.
Sandra Raimbault +13 more
wiley +1 more source