Results 11 to 20 of about 10,244 (214)

NMDA receptor antagonists attenuate intrathecal morphine-induced pruritus through ERK phosphorylation

Molecular Brain, 2018
Pruritus is the most common complication of intrathecal morphine; however, its exact molecular mechanism is unclear, and treatment is challenging. The analgesic effect of N-methyl-D-aspartate (NMDA) receptor antagonists and the morphine-associated ...
Le Shen, Weijia Wang, Siyu Li, Jing Qin, Yuguang Huang   +4 more
doaj   +2 more sources

Efficacy and Safety of Ropivacaine Addition to Intrathecal Morphine for Pain Management in Intractable Cancer [PDF]

Mediators of Inflammation, 2015
Objective. Although intrathecal drug infusion has been commonly adopted for terminal cancer pain relief, its adverse effects have made many clinicians reluctant to employ it for intractable cancer pain.
Ying Huang, Xihan Li, Tong Zhu, Jian Lin, Gaojian Tao   +4 more
doaj   +2 more sources

Super analgesia of intrathecal morphine may be related to ABCB1 (MDR1) gene polymorphism

Journal of Pain Research, 2018
Wangjun Qin,1,* Botao Liu,2,* Ang Deng,1 Ying Liu,1 Xianglin Zhang,1 Lei Zhang1 1Department of Pharmacy, China-Japan Friendship Hospital, Beijing, China; 2Department of Pain Management, China-Japan Friendship Hospital, Beijing, China *These authors ...
Qin WJ, Liu BT, Deng A, Liu Y, Zhang XL, Zhang L   +5 more
doaj   +1 more source

Intrathecal morphine administration reduces postoperative pain and peripheral endocannabinoid levels in total knee arthroplasty patients: a randomized clinical trial

BMC Anesthesiology, 2018
Background The primary goal of this study was to determine whether administration of intrathecal morphine reduces postoperative pain. The secondary goal was to determine the effect of intrathecal morphine upon circulating levels of the weakly analgesic ...
Martin Kaczocha, Syed Azim, James Nicholson, Mario J. Rebecchi, Yong Lu, Tian Feng, Jamie L. Romeiser, Ruth Reinsel, Sabeen Rizwan, Shivam Shodhan, Nora D. Volkow, Helene Benveniste   +11 more
doaj   +2 more sources

Intrathecal morphine plus general anesthesia in cardiac surgery: effects on pulmonary function, postoperative analgesia, and plasma morphine concentration [PDF]

Clinics, 2009
OBJECTIVES: To evaluate the effects of intrathecal morphine on pulmonary function, analgesia, and morphine plasma concentrations after cardiac surgery. INTRODUCTION: Lung dysfunction increases morbidity and mortality after cardiac surgery.
Luciana Moraes dos Santos, Verônica Cavani Jorge Santos, Silvia Regina Cavani Jorge Santos, Luiz Marcelo Sá Malbouisson, Maria José Carvalho Carmona   +4 more
doaj   +2 more sources

Systematic Literature Review of Spinal Cord Stimulation in Patients With Chronic Back Pain Without Prior Spine Surgery

Neuromodulation: Technology at the Neural Interface, EarlyView., 2021
Abstract Objective Low back pain is the leading cause of disability worldwide and one of the most common reasons for seeking healthcare. Despite numerous care strategies, patients with low back pain continue to exhibit poor outcomes. Spinal cord stimulation (SCS) is an evidence‐based therapeutic modality for patients with failed back surgery syndrome ...
Jan M. Eckermann, Julie G. Pilitsis, Christopher Vannaboutathong, Belinda J. Wagner, Rose Province‐Azalde, Markus A. Bendel   +5 more
wiley   +1 more source

A double-blind, randomised, placebo-controlled trial comparing intrathecal bupivacaine with bupivacaine plus morphine to reduce delirium in patients with hip fractures—Salmon-Mind trial study protocol

BJA Open, 2023
Background: Surgical treatment of proximal femur fractures is complicated by postoperative delirium in about one-third of patients. Pain and opioid consumption are modifiable factors that may influence the incidence of delirium.1 An intrathecal injection
Aart Jan W. Teunissen, Mark V. Koning, Willem J. Liefers, Dawi v.d. Stap, Gert Roukema, Bart de Bruijn, Charlotte E. Teunissen, Seppe A. Koopman   +7 more
doaj   +1 more source

Intrathecal Morphine Injection for Postoperative Analgesia Following Gender-Affirming Pelvic Surgery: A Retrospective Case-Control Study [PDF]

, 2023
Background Gender-affirming pelvic surgery (GAPS) can be associated with significant postoperative pelvic pain. Given the lack of available peripheral nerve blocks to the perineum, intrathecal morphine (ITM) injection could offer a potent analgesic ...
Sztain, Jacklynn F, Sztain, Jacklynn, Swisher, Matthew W, Anger, Jennifer T, Tsuda, Paige S, Dolendo, Isabella M, Alexander, Brenton S, Said, Engy T   +7 more
core   +1 more source

Impact of Intrathecal Fentanyl on Hospital Outcomes for Patients Undergoing Primary Total Hip Arthroplasty With Neuraxial Anesthesia

Arthroplasty Today, 2021
Background: Intrathecal opioids have been used to reduce pain after total joint arthroplasty; however, the utility of these drugs is disputed. We examined the impact of eliminating intrathecal fentanyl on outcomes for patients undergoing direct anterior ...
McKayla Kelly, BS, Justin Turcotte, PhD, MBA, Jacob Aja, PA-C, James MacDonald, MD, Paul King, MD   +4 more
doaj   +1 more source

Postoperative effects and complications of intrathecal morphine compared to epidural analgesia in patients undergoing intracorporeal robot-assisted radical cystectomy: a retrospective study

BMC Anesthesiology, 2023
Background Analgesia after robot assisted radical cystectomy aims to reduce postoperative pain and opioid consumption, while facilitating early mobilization and enteral nutrition and minimizing complications.
Sanne de Bock, Carl J. Wijburg, Mark V. Koning   +2 more
doaj   +1 more source