Results 31 to 40 of about 64,466 (204)

Reduced activity of adenylyl cyclase 1 attenuates morphine induced hyperalgesia and inflammatory pain in mice

Frontiers in Pharmacology, 2022
Opioid tolerance, opioid-induced hyperalgesia during repeated opioid administration, and chronic pain are associated with upregulation of adenylyl cyclase activity.
Kayla Johnson, Alexis Doucette, Alexis Edwards, Aleeya Verdi, Ryan McFarland, Shelby Hulke, Amanda Fowler, Val J. Watts, Amanda H. Klein   +8 more
doaj   +1 more source

Effects of Intraperitoneal and Intrathecal Morphine Analgesia on the Expression of μ-Opioid Receptors in Bone Cancer Pain Rats

Dose-Response, 2019
Backgrounds: This study compared analgesic effects and μ-opioid receptor expression levels during long-term intraperitoneal and intrathecal treatment in a bone cancer pain rat.
Wei Liu, Heqi Liu, Zongde Zhang, Jiapeng Huang   +3 more
doaj   +1 more source

Remote intrathecal morphine preconditioning is ineffective in the presence of neuraxial blockade with lidocaine

Kaohsiung Journal of Medical Sciences, 2014
Remote intrathecal morphine preconditioning (RMPC) induces cardioprotection via a neural pathway. Intrathecal lidocaine (LID) blocks spinal cord nerve transmission. This study examine whether LID prevents the effects of RMPC.
Yao Lu, Gordon Tin Chun Wong, Ye Zhang, Jun Hu, Chunshan Dong   +4 more
doaj   +1 more source

Serious Adverse Events after a Single Shot of Intrathecal Morphine: A Case Series and Systematic Review

Pain Research and Management, 2022
Background. The dose of intrathecal morphine is important because of its narrow therapeutic range. Due to a compounding error, pharmacy-compounded, ready-to-use syringes contained 1 mg ml−1 morphine instead of the intended 50 mcg ml−1.
Mark V. Koning, Elmer Reussien, Beatrijs A. N. Vermeulen, Svenja Zonneveld, Elsbeth M. Westerman, Jurgen C. de Graaff, Bernard M. Houweling   +6 more
doaj   +1 more source

Intrathecal morphine related perioperative hypothermia in women undergoing caesarean section: A retrospective case-control study

, 2018
Purpose: Rates of inadvertent perioperative hypothermia among women undergoing spinal anesthesia for cesarean delivery are reported to be high. Intrathecal morphine has been noted to have a potentially potent effect on thermoregulation.
Judy Munday, Yates, Patsy, Sonya Osborne, Osborne, Sonya, Patsy Yates, Munday, Judy   +5 more
core   +1 more source

Palonosetron versus ondansetron for prevention of nausea and vomiting after total abdominal hysterectomy under spinal anesthesia with intrathecal morphine: a double-blind, randomized controlled trial

BMC Anesthesiology, 2019
Background Hysterectomy is a widely performed surgery and neuraxial anesthesia with intrathecal morphine provides superior quality of recovery. Postoperative nausea and vomiting (PONV) is a frequent problem with intrathecal morphine use.
Guilherme Oliveira Campos, Marcelo de Jesus Martins, Gabriel Nascimento Jesus, Paulo Roberto Rios de Oliveira, Caio Nogueira Lessa, João Carlos Macêdo Fernandes de Oliveira Junior, Lucas Jorge Santana de Castro Alves, Rodrigo Leal Alves, Norma Sueli Pinheiro Módolo   +8 more
doaj   +1 more source

Efficacy of intrathecal morphine administration in pediatric patients undergoing selective dorsal rhizotomy

Journal of Pediatric Rehabilitation Medicine, 2023
PURPOSE: The purpose of this study was to evaluate the effectiveness of intrathecal morphine following selective dorsal rhizotomy in pediatric patients previously diagnosed with cerebral palsy.
Jared Pennington, Shawnelle Contini, Miraides Brown, Nupur Goel, Tsulee Chen   +4 more
doaj   +1 more source

Monoclonal antibody targeting mu-opioid receptor attenuates morphine tolerance via enhancing morphine-induced receptor endocytosis

Journal of Pharmaceutical Analysis, 2023
Morphine is a frequently used analgesic that activates the mu-opioid receptor (MOR), which has prominent side effects of tolerance. Although the inefficiency of morphine in inducing the endocytosis of MOR underlies the development of morphine tolerance ...
Jia-Jia Zhang, Chang-Geng Song, Miao Wang, Gai-Qin Zhang, Bin Wang, Xi Chen, Peng Lin, Yu-Meng Zhu, Zhi-Chuan Sun, Ya-Zhou Wang, Jian-Li Jiang, Ling Li, Xiang-Min Yang, Zhi-Nan Chen   +13 more
doaj   +1 more source

Repurposing antimicrobial agents for neuroprotection: Mechanisms, clinical potential, and challenges

Neuroprotection, EarlyView.
Antimicrobial agents exert neuroprotective effects through modulation of interconnected pathways. Tetracyclines, macrolides, antimalarial agents, sulfones, and antiparasitic agents suppress neuroinflammation, oxidative stress, and apoptosis while preserving mitochondrial function and neurotransmission.
Mohammad Amin Manavi, Mohammadreza Salehi, Razieh Mohammad Jafari, Ramin Goudarzi, Saman Khosravi, Ahmad Reza Dehpour   +5 more
wiley   +1 more source

Effect of intrathecal opioid dose variation on patient outcomes in cesarean sections on a remote Indonesian island: a randomized controlled trial

Вестник интенсивной терапии
INTRODUCTION: Intrathecal opioids are routinely used as adjuvants to spinal anesthesia for cesarean section to improve postoperative analgesia. While intrathecal morphine is considered the gold standard, the optimal dose that balances analgesic efficacy
Joshua Christian Suyanto, M. P. Nugroho, P. J. Nareswari   +2 more
doaj   +1 more source