Results 61 to 70 of about 18,654 (227)

The transversus abdominis plane block in conjunction with intrathecal morphine use after cesarean section in women with severe pre-eclampsia: a randomized controlled trial

BMC Anesthesiology, 2023
Background The transversus abdominis plane (TAP) block in conjunction with intrathecal morphine has been demonstrated to provide more superior postcesarean analgesia to intrathecal morphine alone.
Zhi-rong Yan, Li-juan Chen, Su-jing Zhang, Long-xin Zhang, Huan Lu, Li Zhang, Ming Liu, Min Zhou, Li-hua Lin   +8 more
doaj   +1 more source

Postoperative pain treatment after spinal fusion surgery: a systematic review with meta-analyses and trial sequential analyses

PAIN Reports, 2022
. Patients undergoing spinal surgery are at high risk of acute and persistent postoperative pain. Therefore, adequate pain relief is crucial. This systematic review aimed to provide answers about best-proven postoperative analgesic treatment for patients
Anja Geisler, Josephine Zachodnik, Kasper Køppen, Rehan Chakari, Rachid Bech-Azeddine   +4 more
doaj   +1 more source

Intrathecal morphine as sole analgesic during labour. [PDF]

BMJ, 1980
In 12 consecutive unselected patients admitted to a consultant maternity unit one single injection of subarachnoid morphine sulphate 1.5 mg abolished pain during the first stage of labour. Pain in the second stage was abolished in four patients and lessened in three.
P V, Scott, F E, Bowen, P, Cartwright, B C, Rao, D, Deeley, H G, Wotherspoon, I M, Sumrein   +6 more
openaire   +2 more sources

A Review of Nanoparticle‐Based Astrocyte Modulation in CNS Disorders: Evaluating the Underexplored Potential of Intranasal Delivery

Nano Select, Volume 7, Issue 1, January 2026.
Nanoparticle‐driven nose‐to‐brain drug delivery offers a noninvasive approach to bypass the blood–brain barrier (BBB) and directly modulate reactive astrocytes in CNS disorders. This review highlights biodegradable nanoparticles for astrocyte modulation, enhancing drug bioavailability, sustained release, and neuroinflammation control.
Senamile M. Dlamini, Gillian D. Mahumane, Pradeep Kumar, Yahya E. Choonara   +3 more
wiley   +1 more source

Controlled release ibuprofen-poloxamer gel for epidural use - A pharmacokinetic study using microdialysis in pigs [PDF]

, 2016
In order to avoid the risks of sideeffects of epidural local anesthetics and opioids, the use of nonsteroidal anti-inflammatory drugs (NSAIDs) epidurally would be an interesting option of analgesic therapy. The fairly short duration of action of spinally
Bernards, Christopher M., Paavola, Anne, Rosenberg, Per H.   +2 more
core   +1 more source

Physiologically‐Based Pharmacokinetic Modeling to Support Pediatric Clinical Development: An IQ Working Group Perspective on the Current Status and Challenges

CPT: Pharmacometrics &Systems Pharmacology, Volume 15, Issue 1, January 2026.
ABSTRACT Pediatric extrapolation strategies issued by health authorities have streamlined pediatric drug development and reduced the unnecessary burden of conducting pediatric clinical studies. In line with these strategies, physiologically based pharmacokinetic (PBPK) models have been utilized extensively for initial dosing regimen and sampling ...
James W. T. Yates, Michael Zientek, Kunal S. Taskar, Wen Lin, Tycho Heimbach, Stefan Willmann, Jessica Rehmel, Neil Parrott, Michael Hanley, Justine Badee, Yuan Chen, Susan Cole, Loeckie De Zwart, Sebastian Haertter, Rongrong Jiang, Masakatsu Kotsuma, Guiqing Liang, Yu‐Wei Lin, Jing Liu, Ying Ou, Juliane Rascher, Naveed A. Shaik, Jan Wahlstrom, Xiaofeng Wang, Guangqing Xiao, Ka Lai Yee, S. Y. Amy Cheung   +26 more
wiley   +1 more source

Delayed postoperative gastric emptying following intrathecal morphine and intrathecal bupivacaine [PDF]

Canadian Journal of Anesthesia/Journal canadien d'anesthésie, 1999
A decrease in the rate of gastric emptying can delay resumption of enteral feeding, alter bioavailability of orally administered drugs, and result in larger residual gastric volumes, increasing the risk of nausea and vomiting. We compared the effects of 1) intrathecal bupivacaine (17.5 mg) and 2) the combination of intrathecal morphine (0.6 mg) and ...
A M, Lydon, T, Cooke, F, Duggan, G D, Shorten   +3 more
openaire   +2 more sources

Treatment of Medically Refractory Cancer Pain with a Combination of Intrathecal Neuromodulation and Neurosurgical Ablation: Case Series and Literature Review [PDF]

, 2014
Objective Up to 90% of patients with advanced cancer experience intractable pain. For these patients, oral analgesics are the mainstay of therapy, often augmented with intrathecal drug delivery.
Bentley, J. Nicole, Patil, Parag G., Rosenberg, William S., Viswanathan, Ashwin   +3 more
core   +1 more source

Comparison of two peripheral regional analgesic techniques for primary elective total hip arthroplasty: a randomised clinical trial

Anaesthesia, Volume 80, Issue 12, Page 1501-1509, December 2025.
Summary Introduction Several regional anaesthesia techniques have been used in the peri‐operative pain management of patients who undergo primary elective total hip arthroplasty. The erector spinae plane, pericapsular nerve group and lateral femoral cutaneous nerve blocks offer motor‐sparing analgesia of the hip region but target different areas.
Francesca Buffoli, Claudia Bonetti, Camilla Pugno, Andrea Minini, Silvia Bettinelli, Arianna Mancini, Alessandro Colombi, Alberto Benigni, Edward R. Mariano, Luca F. Lorini, Dario Bugada   +10 more
wiley   +1 more source

Benefit and risk of intrathecal morphine without local anaesthetic in patients undergoing major surgery: meta-analysis of randomized trials [PDF]

, 2017
Intrathecal morphine without local anaesthetic is often added to a general anaesthetic to prevent pain after major surgery. Quantification of benefit and harm and assessment of dose-response are needed.
Elia, N., Lysakowski, C., Meylan, N., Tramèr, M. R.   +3 more
core