Results 111 to 120 of about 39,887 (243)

Electronic nose responses and acute phase proteins correlate in blood using a bovine model of respiratory infection [PDF]

, 2010
This study aimed (i) to assess the ability of electronic nose (e-nose) technology to differentiate between blood samples of experimentally infected and non-infected subjects, and (ii) to evaluate e-nose responses given by volatile organic compounds in ...
Chambers, M, Chambers, Mark, Schroedl, W, Reinhold, Petra, Turner, C, Turner, Claire, Knobloch, H, Reinhold, P, Knobloch, Henri, Schroedl, Wieland   +9 more
core   +1 more source

DOT1L Drives Endothelial‐to‐Mesenchymal Transition and Fibrotic Vascular Remodeling via H3K79 Methylation

Advanced Science, Volume 13, Issue 34, 19 June 2026.
DOT1L as a central epigenetic regulator of EndoMT and pulmonary fibrosis. Acting as an early epigenetic switch, it translates TGFβ–SMAD signaling into H3K79me2‐mediated chromatin remodeling, selectively activates fibrosis‐related genes, and primes ECs for rapid mesenchymal transition.
Yaofeng Wang, Xing Peng, Jingjing Chen, Yun Zhang, Tinghong Zhang, Jingyuan Zhang, Jiaying Fan, Hui Zheng, Qiaoyuan Liu, Zhimin Song, Zhan‐Peng Huang, Shu Meng   +11 more
wiley   +1 more source

Intratracheal adenovirus-mediated gene transfer is optimal in experimental lung transplantation

, 2002
Objective: Gene transfer to experimental lung grafts has been shown to reduce ischemia-reperfusion injury and acute rejection. The optimal delivery route should produce high lung expression with no inflammation and minimal systemic expression.
Kozower, Benjamin D., Patterson, G.Alexander, Daddi, Niccolò, Mohanakumar, T., Ritter, Jon H., Kanaan, Samer A., Suda, Takashi, Tagawa, Tsutomu   +7 more
core   +1 more source

Anesthetic challenges in leaking meningomyelocele repair in a neonate

Journal of Marine Medical Society, 2019
Meningomyelocele is a neural tube defect, which comprises of a saccular protrusion containing a neural placode bathed in cerebral spinal fluid. Arachnoid covers the surface of the sac and dura or skin is missing.
Vidhu Bhatnagar, S N Kulkarni, M D Muzammil   +2 more
doaj   +1 more source

A Nanoparticle‐Integrated Complete Manufacturing Pipeline of Chemically Engineered Exosomes

Advanced Science, Volume 13, Issue 32, 9 June 2026.
We report a novel manufacture technology of chemically engineered exosomes. The four steps of manufacturing, i.e., biogenesis, loading, isolation, and storage, are integrated by the use of a nanoparticle. The manufacture technology incorporates three innovative components, i.e., a new nano‐bio effect, a new composite nanoparticle, and a new isolation ...
Xiaowei Wen, Zixing Xu, Zerun Hao, Yanming Chen, Kai Xie, Haofan Yin, Xueying Wang, Jie Min, Sihan Sun, Baiding Chen, Chengxiu Ling, Mingming Xu, Yizhao Chen, Gang Ruan   +13 more
wiley   +1 more source

Intratracheal injection of LPS and cytokines. V. LPS induces expression of LIF and LIF inhibits acute inflammation

, 1994
Lipopolysaccharide (LPS) injected into the trachea of rats was found to induce the secretion of leukemia inhibitory factor (LIF) into bronchoalveolar lavage (BAL) fluid with a maximum expression of LIF after 2-12 h.
Fann, Ming-Ji, Del Castillo, Juan, Remick, Daniel G., Ulich, Thomas R., Guo, Kaizhi, Samal, Barru, Williams, James H., Patterson, Paul H., Yin, Songmei   +8 more
core   +2 more sources

Localized NF‐κB Inhibition Reduces Lipid Nanoparticle‐Associated Inflammation

Advanced Science, Volume 13, Issue 31, 4 June 2026.
Lipid nanoparticles (LNPs) activate NF‐κB and provoke inflammation that limits therapeutic delivery. By encapsulating selective NF‐κB inhibitors within LNPs, localized suppression of inflammatory signaling is achieved without compromising mRNA expression.
Carolann L. Espy, Jichuan Wu, Serena Omo‐Lamai, Liuqian Wang, Fengyi Dong, Aleksa Milosavljevic, Sarah O'Neill, Taylor Brysgel, Yufei Wang, Michael Zaleski, Emily Wolfe, Rhea Maheshwari, Manthan Patel, Dirk Trauner, Jia Nong, Zhicheng Wang, Jacob S. Brenner   +16 more
wiley   +1 more source

Role of C fibers in the inflammatory response to intratracheal lipopolysaccharide

, 1996
We proposed that C fibers play a role in mediating the inflammatory response to the intratracheal instillation of lipopolysaccharaide (LPS), a purified form of endotoxin.
C. W. Frevert, S. A. Shore, N. C. Long
core   +1 more source

Intratracheal instillation of corticosteroids combined with surfactant for preventing chronic lung disease in preterm infants

This is a protocol for a Cochrane Review (intervention). The objectives are as follows: Primary objective To evaluate the benefits and harms of intratracheal instillation of corticosteroids combined with surfactant versus surfactant alone for the ...
Pahl, Adrienne, Gautham, Kanekal S, Borys, Franciszek, Bolanos, Luis, Fiander, Michelle, Soll, Roger F, Cracknell, Jane, Bruschettini, Matteo   +7 more
core   +1 more source

Intratracheal Administration of siRNA Dry Powder Targeting Vascular Endothelial Growth Factor Inhibits Lung Tumor Growth in Mice

, 2018
Inhalation therapy using small-interfering RNA (siRNA) is a potentially effective therapeutic strategy for lung cancer because of its high gene-silencing effects and sequence specificity.
Takeshi Masuda, Yasushi Horimasu, Shintaro Miyamoto, Taku Nakashima, Hirokazu Okamoto, Ayumi Shibata, Daisuke Ihara, Hironobu Hamada, Kei Miwata, Noboru Hattori, Kazunori Fujitaka, Takaaki Ito, Hiroshi Iwamoto, Tomoyuki Okuda   +13 more
core   +1 more source