Results 121 to 130 of about 77,359 (282)
International Journal of Molecular Sciences, 2014 The potential immune effects of titanium dioxide nanoparticles (nano-TiO2) are raising concern. Our previous study verified that nano-TiO2 induce local immune response in lung tissue followed by intratracheal instillation administration.
Yanyun Fu +8 more
semanticscholar +1 more source
Small Structures, EarlyView.This article highlights the fibrous morphology of multiwalled carbon nanotubes as a key factor in their genotoxicity. Fibers physically interfere in cell division, generating binucleated cells and micronuclei, both of which are precursors of carcinogenesis.
Núria Pulido‐Artola +4 more
wiley +1 more source
Residual tumor cells that drive disease relapse after chemotherapy do not have enhanced tumor initiating capacity. [PDF]
, 2012 Although chemotherapy is used to treat most advanced solid tumors, recurrent disease is still the major cause of cancer-related mortality. Cancer stem cells (CSCs) have been the focus of intense research in recent years because they provide a possible ...
de la Cruz, Cecile +5 more
core +2 more sources
Journal of Toxicologic Pathology, 2014 Intratracheal instillation is widely used for respiratory toxicity tests in experimental animals. However, there are wide variations in the techniques used for instillation, and it is thus difficult to compare the results obtained using different ...
Yasuko Hasegawa-Baba +3 more
semanticscholar +1 more source
DLD‐HLNP/P@IR780 for efficient lung‐parenchyma accumulation to treat idiopathic pulmonary fibrosis
VIEW, EarlyView.DLD‐HLNP/P@IR780 was synthesized to target to lung and treat IPF by releasing pirfenidone. It could effectively traverse pulmonary ECB and accumulate in lung parenchyma by IR780 binding to CD300LF and MRC1 which are abundantly and specifically expressed on pulmonary endothelial cell and pulmonary macrophages.
Mengzhu Wang +3 more
wiley +1 more source
Relationship of arterial and exhaled CO2 during elevated artificial pneumoperitoneum pressure for introduction of the first trocar. [PDF]
, 2011 The present study evaluated the correlation between arterial CO2 and exhaled CO2 during brief high-pressure pneumoperitoneum. Patients were randomly distributed into two groups: P12 group (n=30) received a maximum intraperitoneal pressure of 12mmHg ...
Afonso C. C. G. Machado +11 more
core +1 more source
T3 Intratracheal Therapy Alleviates Pulmonary Pathology in an Elastase-Induced Emphysema-Dominant COPD Mouse Model [PDF]
, 2023 N. Takahashi +14 more
openalex +1 more source
Nanotoxicology, 2014 The use of carbon nanotubes in the industry has grown; however, little is known about their toxicological mechanism of action. Single-wall carbon nanotube (SWCNT) suspensions were administered by single intratracheal instillation in rats.
K. Fujita +9 more
semanticscholar +1 more source
Aging Cell, EarlyView.Our research firstly indicated that age‐dependent upregulation of tissue kallikrein‐related peptidase 8 (KLK8) induces endothelial senescence through modulating the fibronectin‐FAK‐Akt‐PARP1/2 axis, thereby increasing the vulnerability of aged mice to low‐tidal‐volume ventilator‐induced lung injury (VILI).
Di Liu +7 more
wiley +1 more source